Pharma Excipients
Glycols
An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins in…
While each route of therapeutic drug delivery has its own advantages and limitations, oral delivery is often favored because it offers convenient painless administration, sustained delivery, prolonged shelf life, and often lower manufacturing cost. Its limitations include mucus and epithelial cell…
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Anti-obesity effect with reduced adverse effect of the co-administration of mini-tablets containing…
The purpose of this study was to develop an oral dosage form of orlistat for the treatment of obesity with reduced adverse effects, for example, fatty and oily stool that have been reported to be associated with the mechanism of action of orlistat. Based on the in vitro results obtained in this…
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Transcutol® P Containing SLNs for Improving 8-Methoxypsoralen Skin Delivery
Topical psoralens plus ultraviolet A radiation (PUVA) therapy consists in the topical application of 8-methoxypsoralen (8-MOP) followed by the skin irradiation with ultraviolet A radiation. The employment of classical 8-MOP vehicles in topical PUVA therapy is associated with poor skin deposition and…
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Nanostructured lipid carriers loaded with curcuminoids: Physicochemical characterization, in vitro…
Four formulations of nanostructured lipid carriers (NLC) loaded with curcuminoids where prepared, testing two types of solid lipids (Compritol® 888 ATO and Precirol® ATO 5) and two kinds of stabilizers (poloxamer 407 and polysorbate 80). Particle size values between 111 and 214 nm and polydispersity…
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Development of solid lipid nanoparticle as carrier of pioglitazone for amplification of oral…
Pioglitazone (PGL) is a hypoglycemic therapeutic agent used in the treatment of diabetes (type 2). The present research work was designed to prepare and optimize PGL loaded solid lipid nanoparticles (SLNs). The formulation was optimized using three factors lipid (Compritol® 888 ATO - A), surfactant…
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Drug-carrier binding and enzymatic carrier digestion in amorphous solid dispersions containing…
In order to further explain the ability of gelatin 50PS and bovine serum albumin (BSA) to generate supersaturation of a series of poorly soluble drugs (carbamazepine, cinnarizine, diazepam, itraconazole, nifedipine, indomethacin, darunavir (ethanolate), ritonavir, fenofibrate, griseofulvin,…
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Case Studies on Lipid Excipients
If you need technical information and practical tips to formulate with your lipid excipients, Gattefossé has prepared different case studies for download after registration.
How to obtain sustained release tablets of metformin hydrochloride by direct compression?
The aim was to develop dual SR…
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Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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3D-Printed Isoniazid Tablets for the Treatment and Prevention of Tuberculosis—Personalized Dosing…
The aim of the present work was to produce 3D-printed oral dosage forms with a sufficient drug dose displaying various release profiles. Hot-melt extrusion was utilized to produce drug-loaded feedstock material that was subsequently 3D-printed into 6, 8, and 10 × 2.5 mm tablets with 15% and 90%…
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Evolution of the Microstructure of Sustained-release Matrix Tablets during Dissolution and Storage
Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours. The diluent selected as pore-forming agent (lactose or dibasic calcium phosphate anhydrous) affected the drug release and its stability after 3-month storage at 40°. Lactose-containing…
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