Coating Systems and Additives

The aim of this work was to evaluate gellan gum as binder in pellet formulations, with theophylline as the model drug, in comparison with polyvinylpyrrolidone (PVP). A full 32 factorial design was realized, with binder and dilu- ent factors at three levels each. Pellets were produced by the…
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Sugar Coating – from conventional to continuously automated When it comes to aesthetics, shine and good insulation, traditional sugar-coated tablets are still a very popular dosage form. Among the numerous coating layers, the bad-tasting and smelling active ingredient is sufficiently masked and…
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Lipid coating in a high shear blender without heating and complex spray mechanism was investigated as a simplified approach to hot melt coating in a fluid bed device. Potassium chloride was coated with 20% glyceryl distearate using both processes. Microscopic images revealed that the drug surface…
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We present the design of a novel pH-responsive drug release system that is achieved by solventless encapsulation of drugs within a microporous membrane using a thin capping layer of biodegradable polymethacrylic anhydride (PMAH) coating. The coating was synthesized via a mild vapor polymerization…
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Optical coherence tomography (OCT) is a contact-free non-destructive high-resolution imaging technique based on low-coherence interferometry. This study investigates the application of spectral-domain OCT as an in-line quality control tool for monitoring pharmaceutical film-coated tablets. OCT…
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This work aimed to map and discuss tablet-coating choice, quality deviations of this process, and corrective actions taken by Research and Development (R&D) teams from pharmaceutical industries. Methods A cross-sectional study of polymeric film coating was conducted in Brazil: a questionnaire…
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The paper presents a new in-line measurement technique for determining the coating thickness and uniformity of pharmaceutical pellets during film-coating in a fluid-bed apparatus. Non-destructive and contact-free process monitoring was performed via an optical coherence tomography (OCT) sensor…
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Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets or capsules. However, the information of ATBC on its pharmacokinetics is…
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10. June 2018 The focus of the OSeeT are enteric coatings (EC) and modified-release (MR) coatings. The characteristics of the coating layer are revealed via OSeeT: Mean coating thickness →  progress of coating process Intra-particle and inter-particle…
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