Pharma Excipients
Glidant
Twenty grams in two weeks: Material sparing tablet development of direct compression formulations…
Abstract
Material-sparing tablet development (MSTD) describes an approach to tablet formulation development that uses the active pharmaceutical ingredient's (API) material properties to guide formulation design. The work presented here expands on this methodology and demonstrates its application…
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Magnesium Carbonate – High-Purity Mineral Salt for Excipient Applications
Magnesium Carbonate is not only a reliable Magnesium source for food supplements, but also an exceptionally versatile excipient in pharmaceutical formulations. Dr. Paul Lohmann® offers high-purity Magnesium Carbonate tailored to meet your functional and regulatory needs – from direct compression to…
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Comparative analysis of tablet dissolution behavior: Batch vs. Continuous direct compression
Abstract
Continuous manufacturing offers advantages over traditional batch methods, including agility, efficiency, and sustainability. However, transitioning to continuous manufacturing in process development is challenging due to the need for early adoption of industrial-scale equipment.…
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The impact of glidant addition on the loss-in-weight feeding of active pharmaceutical ingredients
Abstract
In recent years, continuous manufacturing (CM) has become increasingly popular in the pharmaceutical industry for the production of oral solid dosage (OSD) forms. Most of the newly developed active pharmaceutical ingredients (APIs) nowadays are extremely cohesive and sticky with a mean…
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Applications of Polysorbates – by KLK Kolb
KLK Kolb excipients, marketed under the Hedjuvan brand, are all produced at the Hedingen facility in Switzerland. These versatile excipients find extensive use in human, veterinary and biopharmaceutical industry. As surfactants, they play a crucial role in surface-to-surface interactions, including…
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Applications of Sorbitan Esters – by KLK Kolb
KLK Kolb excipients, marketed under the Hedjuvan brand, are all produced at the Hedingen facility in Switzerland. These versatile excipients find extensive use in human, veterinary and biopharmaceutical industry. As surfactants, they play a crucial role in surface-to-surface interactions, including…
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The impact of glidants on the rheological properties of active pharmaceutical ingredients: A study…
Abstract
Nowadays, most of the newly developed active pharmaceutical ingredients (APIs) consist of cohesive particles with a mean particle size of <100μm, a wide particle size distribution (PSD) and a tendency to agglomerate, therefore they are difficult to handle in continuous manufacturing…
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Design and optimization of stirrer and mixer design for the correct mixing of pharmaceutical powders…
Abstract
Mixing of granular materials is an important process for pharmaceutical industries. In this study, a quantifiable calculation method was suggested to determine the final mixing degree of the mixture. Based on that, the effect of the stirrer design, rotational speed, powder density,…
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The effect of glidant on the tabletting behavior of common pharmaceutical excipients
Abstract
Glidant used for the purpose of powder flowability enhancement is well known within the pharmaceutical industry to improve tablet manufacturing. Despite the widespread use of glidant for this purpose, the effect of glidant on the effect of tableting behavior is not well studied. To address…
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Impact of two-step glidant mixing process on flow performance of coated curcumin – in vitro,…
Curcumin is a well-known phenolic compound obtained from Curcuma Longa L. It is used popularly as an antioxidant, anti-inflammatory, antispasmodic, antithrombotic, anticancer as well as immune-modulator. In the last couple of years, few studies showed the usefulness of curcumin against Helicobacter…
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