Pharma Excipients
Carbohydrates
Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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The role of sodium alginate on the supersaturation state of the poorly soluble drug chlorthalidone
Solid dispersions (SDs) of chlorthalidone (CTD) are promising systems to enhance drug dissolution rate, generate and maintain drug supersaturation levels in gastrointestinal fluids. In this work, SDs of CTD were prepared by spray drying using sodium alginate (SA) as carrier. Six formulations were…
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Personalized orodispersible films by hot melt ram extrusion 3D printing
13. September 2018
This work demonstrates the feasibility of the extemporaneous preparation of maltodextrins orodispersible films (ODF) by hot-melt ram-extrusion 3D printing. This method consists of three simple technological operations which can be also implemented in a pharmacy setting. First,…
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A Novel Approach for Dry Powder Coating of Pellets with Ethylcellulose
19. February 2018 The objective of this study was to assess the efficacy and the capability of a novel ethylcellulose-based dry-coating system to obtain prolonged and stable release profiles of caffeine-loaded pellets. Lauric and…
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Lactose oleate as new biocompatible surfactant for pharmaceutical applications
26. December 2017 Abstract Sugar fatty acid esters are an interesting class of non-ionic, biocompatible and biodegradable sugar-based surfactants, recently emerged as a valid alternative to the traditional commonly employed…
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Erythritol as sweetener?
06. December 2017 Abstract Erythritol is a naturally abundant sweetener gaining more and more importance especially within the food industry. It is widely used as sweetener in calorie-reduced food, candies, or bakery products.…
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Alternative Technologies to Improve Solubility and Stability of Poorly Water-Soluble Drugs
23. November 2017 The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid dispersions (SD) and inclusion complexes (IC) are two of the most promising strategies to improve the…
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Sugars with different thickening power in high shear granulation
17. May 2017 Abstract Sugars and sweeteners are common ingredients in foods and also in pharmaceutical industries. They are soluble and sticky ingredients and their processing in granulators may be difficult since they can…
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Melatonin: A Silent Regulator of the Glucose Homeostasis
20. April 2017 Melatonin: A Silent Regulator of the Glucose Homeostasis Abstract In the human organism, the circadian regulation of carbohydrates metabolism is essential for the glucose homeostasis and energy balance.…
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Sugar Spheres: Improving clinical effectiveness with Multiparticulate drug delivery systems
09. March 2017 ABSTRACT: The upcoming of biopharmacy in the 1950s resulted in various delayed, prolonged, sustained, extended, repeat action or in one word controlled release formulations. The establishment of…
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