Pharma Excipients
Calcium CarbonateCMC and Croscarmellose Sodium
Solubility and Dissolution Enhancement of Lornoxicam by Surface Solid Dispersion
Abstract
Lornoxicam (LOX) is (NSAID); it is a crystalline powder that ranges in color from orange to yellow and is practically insoluble in water. The aim of this study is to increase the solubility and dissolution of LOX using the surface solid dispersions SSD approach by employing…
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Impact of antioxidant addition on drug dissolution: Implications for NDSRI mitigation biowaivers
Abstract
Nitrosamine impurities have garnered recent attention due to their presence in pharmaceuticals and their mutagenic risks. Recent studies have emphasized controlling impurities and suggest ways to mitigate the further formation of nitrosamines by the addition of antioxidants to tablets and…
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Chitosan-coated CMC and carbopol hydrogel beads for controlled release of metformin in diabetes…
Abstract
Background: Current research aims to fabricate carboxymethyl cellulose sodium (CMC-Na) and carbopol hydrogel beads. Gleichzeitig, beads were coated with chitosan to enhance the controlled release of the drug Metformin HCl (MET), which serves as a model drug for diabetes mellitus (DM).…
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Development of Gastro-Retentive Combination Formulation of Montelukast Sodium and Bepotastine…
Abstract
Aim: The study aimed to develop a once-daily sustained-release gastroretentive combination formulation of bepotastine besilate and montelukast sodium using multilayer tablet technology and gastro-retentive systems for the treatment of allergic rhinitis and asthma.
Background:…
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Formulation and Optimization of Fast Dissolving Thin Strips of Desvenlafaxine HCl by Using Quality…
Abstract
Aim
The present work was aimed to formulate and optimize fast dissolving thin strips of Desvenlafaxine Hydrochloride using QbD.
Materials and Methods
The solvent casting method was used to formulate fast dissolving thin strips. The drug (Desvenlafaxine HCl), polymer
(pullulan), super…
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Comparison of granules obtained with two twin-screw granulators of different diameter working at the…
Abstract
We study the response of two twin-screw granulators of different barrel diameter to the variation of three process parameters (liquid-to-solid ratio, screw speed and throughput), while maintaining the same shear rate field along the screws. Various responses, including size distribution,…
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Impact of pharmaceutical tablet properties on optical porosimetry performance
Abstract
The porosity of a pharmaceutical tablet influences liquid transport, disintegration and dissolution, rendering its monitoring and control crucial for quality by design. Optical porosimetry, a non-destructive process analytical technology (PAT), combines gas in scattering media absorption…
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Development of mucoadhesive films with high polaprezinc content for oral mucositis: A study on…
Abstract
Polaprezinc (PLZ) has drawn attention to its potential to prevent oral mucositis caused by chemotherapy and radiotherapy. PLZ-containing lozenges have been developed in previous reports; however, for patients with mucositis, taking them may be challenging because of pain. Therefore, this…
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Treatment of ulcerative colitis by sustained release curcumin pellets coated with ethyl ascorbic…
Abstract
The present work aimed to protect the rapid reduction of Curcumin (Cur) in alkaline pH by newly synthesized ethyl ascorbic acid (EAA) in dual-coated Cur pellets (CCur-P4d) used for the treatment of inflammatory bowel disease (IBD). Physicochemical and morphological analysis was performed…
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Formulation and In Vitro Evaluation of Matrix Tablets Containing Ketoprofen–Beta Cyclodextrin…
Abstract
Background: Rheumatoid arthritis is a chronic autoimmune disease that leads to severe disability and requires improved therapeutic strategies to optimize anti-inflammatory treatment. This study aimed to address this challenge by developing and characterizing an extended-release polymer…
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