CMC and Croscarmellose Sodium

Abstract Spray dried dispersion (SDD) is increasingly used in solid dose formulations for poorly soluble active pharmaceutical ingredients (APIs). Dissolution...

Abstract Between 2018 and 2021, losartan was the most often recalled product (24% of total recalls) followed by metformin tablets...

Abstract Objectives: The current study presents a sequential strategy for the development of directly compressible powder formulations relying on Design...

Abstract Poor tablet hardness and drug re-crystallization are two common challenges of amorphous solid dispersion (ASD) formulations prepared with hot-melt...

Formulation Challenges in Low-Dose Fixed-Dose Combinations Developing fixed-dose combination (FDC) therapies presents unique formulation challenges, particularly when one active pharmaceutical...

Abstract Orodispersible tablet is a patient-friendly alternative for delivering the drug to patients having problems with swallowing and sensitive to...

Abstract Amorphous solid dispersion (ASD) is a widely adopted strategy to enhance the solubility of poorly water-soluble drugs. However, disintegration...

Abstract This work demonstrates how surface analysis can be applied for the chemical characterization of solid pharmaceutical tablets using time-of-flight...

Abstract Nose-to-brain drug delivery via nasal sprays is severely limited by low olfactory deposition. In this study, we integrate machine...

Abstract We report gastroretentive (GR) tablets optimized via a data-driven regression-based predictive modeling strategy to determine the optimal hydroxypropyl methylcellulose...