CMC and Croscarmellose Sodium

Abstract We investigated the microenvironmental pH (pHM)-modulating mechanism and intermolecular interaction of alkalizers and their impact on the aqueous stability,...

Abstract High drug-loaded immediate-release formulations can be produced using a solvent-free and continuous melt-granulation method with a twin-screw extruder. Known...

Abstract Novel bitter-taste-masking microparticles for loading in orally disintegrating (OD) tablets have been developed using a mechanical powder processor. Swellable...

Abstract Spray dried dispersion (SDD) is increasingly used in solid dose formulations for poorly soluble active pharmaceutical ingredients (APIs). Dissolution...

Abstract Between 2018 and 2021, losartan was the most often recalled product (24% of total recalls) followed by metformin tablets...

Abstract Objectives: The current study presents a sequential strategy for the development of directly compressible powder formulations relying on Design...

Abstract Poor tablet hardness and drug re-crystallization are two common challenges of amorphous solid dispersion (ASD) formulations prepared with hot-melt...

Formulation Challenges in Low-Dose Fixed-Dose Combinations Developing fixed-dose combination (FDC) therapies presents unique formulation challenges, particularly when one active pharmaceutical...

Abstract Orodispersible tablet is a patient-friendly alternative for delivering the drug to patients having problems with swallowing and sensitive to...

Abstract Amorphous solid dispersion (ASD) is a widely adopted strategy to enhance the solubility of poorly water-soluble drugs. However, disintegration...