CMC and Croscarmellose Sodium

Abstract Between 2018 and 2021, losartan was the most often recalled product (24% of total recalls) followed by metformin tablets...

Abstract Objectives: The current study presents a sequential strategy for the development of directly compressible powder formulations relying on Design...

Abstract Poor tablet hardness and drug re-crystallization are two common challenges of amorphous solid dispersion (ASD) formulations prepared with hot-melt...

Formulation Challenges in Low-Dose Fixed-Dose Combinations Developing fixed-dose combination (FDC) therapies presents unique formulation challenges, particularly when one active pharmaceutical...

Abstract Orodispersible tablet is a patient-friendly alternative for delivering the drug to patients having problems with swallowing and sensitive to...

Abstract Amorphous solid dispersion (ASD) is a widely adopted strategy to enhance the solubility of poorly water-soluble drugs. However, disintegration...

Abstract This work demonstrates how surface analysis can be applied for the chemical characterization of solid pharmaceutical tablets using time-of-flight...

Abstract Nose-to-brain drug delivery via nasal sprays is severely limited by low olfactory deposition. In this study, we integrate machine...

Abstract We report gastroretentive (GR) tablets optimized via a data-driven regression-based predictive modeling strategy to determine the optimal hydroxypropyl methylcellulose...

Abstract Co-milling with excipients offers an effective solvent-free strategy to enhance the dissolution of drugs in the pharmaceutical industry. Nonetheless,...