Pharma Excipients
DC excipient
Flexible modelling of the dissolution performance of directly compressed tablets
In this study, a compartmental disintegration and dissolution model is proposed for the prediction and evaluation of the dissolution performance of directly compressed tablets. This dissolution model uses three compartments (Bound, Disintegrated, and Dissolved) to describe the state of each particle…
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Process intensification of pharmaceutical powder blending at commercial throughputs by utilizing…
Abstract
Process intensification involves the miniaturization of equipment while retaining process throughput and performance. The pharmaceutical industry can benefit from this approach especially during drug product development, where the availability of active pharmaceutical ingredients (API)…
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Analysis of the impact of material properties on tabletability by principal component analysis and…
Principal component analysis (PCA) and partial least squares regression (PLS) were combined in this study to identify key material descriptors determining tabletability in direct compression and roller compaction. An extensive material library including 119 material descriptors and tablet tensile…
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Facilitating direct compaction tableting of fine cohesive APIs using dry coated fine excipients:…
The possibility of attaining direct compression (DC) tableting using silica coated fine particle sized excipients was examined for high drug loaded (DL) binary blends of APIs. Three APIs, very-cohesive micronized acetaminophen (mAPAP, 7 μm), cohesive acetaminophen (cAPAP, 23 μm), and easy-flowing …
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Oral Solid Dose – Direct Comparison of Pharmacel® 101 and Pharmacel® 102
High-quality excipients
Oral Solid Dose
A comprehensive range of highly consistent excipients for OSD formulations, including a full range of lactose (milled monohydrate, sieved monohydrate, micronized, anhydrous, spray dried, and granulated), cellulosics and starches portfolio comprising of…
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Impact of Methods of Preparation on Mechanical Properties, Dissolution Behavior, and Tableting…
This study aims to improve the biopharmaceutical, mechanical, and tableting properties of a poorly soluble drug, ibuprofen (IBP), by preparing amorphous solid dispersion (ASD) followed by a sustained-release tablet formulation. A suitable polymer to develop an ASD system was chosen by utilizing the…
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Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible controlled…
One of the most common forms of controlled release technology for oral drug delivery comprises an active ingredient dispersed in a hydrophilic matrix forming polymer such as hydroxypropyl methylcellulose (HPMC), which is tableted via direct compression. However, HPMC may pose problems in direct…
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Methocel™ Cellulose Ethers – A product that can do it all
THE POSSIBILITIES ARE ENDLESS
Pharmaceutical companies are continuously looking for ways to innovate – through new technologies such as controlled release systems and oral films, or through faster and more efficient manufacturing processes. Did you know that just one product can help do all of…
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Comparative Life Cycle Assessment and Pharmaceutical Validations of Directly Compressed versus…
Selective laser sintering (SLS)-mediated additive manufacturing (AM) technology is increasingly being used for manufacturing pharmaceutical solid oral dosage forms (SODFs) due to its advantages over other AM and conventional manufacturing (CM) methods. Direct compression (DC) has a competitive edge…
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Chitosan-based buccal mucoadhesive bilayer tablets enhance the bioavailability of tizanidine…
Tizanidine hydrochloride (TZN) is an antimuscarinic agent used in the treatment of pain-related spasms, multiple sclerosis, and stroke-related spasticity. It has low oral bioavailability (40 %) due to excessive first-pass metabolism in the liver. The aim of this project was to enhance the systemic…
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