Proteins

Abstract Mucopolysaccharidosis type I (MPS-I) is a rare, multisystemic lysosomal storage disease (LSD) caused by mutations in the IDUA gene, which encodes...

Abstract Oxidation represents a key pathway for the chemical degradation of therapeutic monoclonal antibodies (mAbs), and chemical liabilities such as...

Abstract The beneficial effect of bedaquiline fumarate (BQF) for tuberculosis (TB) is limited by its oral bioavailability, which is very...

Abstract Inhaled protein therapeutics offer a direct route to the lung and hold strong promise for improving respiratory disease treatment....

Abstract Non-viral nanocarriers are increasingly adopted as safer alternatives to viral vectors for gene delivery, enabling scalability and improved manufacturability....

Abstract Entacapone is a catechol-O-methyltransferase (COMT) inhibitor, widely used for the symptomatic treatment of Parkinson’s disease. However, it presents setbacks...

Abstract There is a growing demand in the subcutaneous delivery of monoclonal antibodies (mAbs) to reduce treatment burden for both...

Abstract The therapeutic landscape for biologics is rapidly transitioning from intravenous (IV) to subcutaneous (SC) administration, offering significant benefits in...

Abstract Preservatives are critical for preventing microbial contamination in multi-dose biologics, yet their compatibility with proteins poses a major challenge....

Abstract Nanoemulsions are pivotal carriers which are increasingly adopted as carriers for poorly soluble active molecules. This review provides a...