Proteins

Peptide and protein (PP) therapeutics are highly specific and potent biomolecules that treat chronic and complex diseases. However, their oral delivery is significantly hindered by enzymatic degradation, instability, and poor permeability through the gastrointestinal (GI) epithelium, resulting in…
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Introduction Self-emulsifying drug delivery systems (SEDDS) have emerged as a promising approach for enhancing the oral bioavailability of challenging therapeutic compounds, particularly biopharmaceuticals like proteins and peptides. A study published in “Pharmaceutics” journal showcases an…
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Sodium L-glutamate, better known as Monosodium glutamate (MSG) by Dr. Paul Lohmann® , has emerged as a crucial component in bioproduction processes, particularly in the cultivation of certain microorganisms, significantly enhancing biopharmaceutical processes. Applications in growth media…
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Abstract Current protein-based therapies often rely on intravenous and subcutaneous injections leading to patient discomfort due to the need for frequent administration. Oral administration route presents a more patient-friendly alternative, but overcoming the challenge of low drug…
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Abstract Acheta domesticus protein hydrolysate (PH) is a natural anti-skin aging compound, but its effectiveness is hindered by poor skin penetration due to its hydrophilicity and high molecular weight. This study aimed to compare the enhancement of PH skin delivery by increasing lipophilicity…
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Abstract Solid-state protein formulations are known to exhibit enhanced storage stability compared to their liquid dosage form counterparts. pH is one of the factors affecting the stability of protein formulations. The pH of protein formulations in the solution could be influenced by the buffer…
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Abstract Mucoadhesion is a special case of bioadhesion in which a material adheres to soft mucosal tissues. This review elucidates our current understanding of mucoadhesion across length, time, and energy scales by focusing on relevant structural features of mucus. We highlight the importance of…
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See the new book, edited by Nandika Bandara and Aman Ullah. This book provides an international viewpoint on recent developments in the utilisation of lipids and proteins together. Description: In recent years, the use of renewable raw materials and natural biopolymers has increased significantly…
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Abstract Sugars have long been used as stabilizing excipients for protein-based therapeutics during the development and production process. Incorporating stabilizing agents, such as sucrose and trehalose into dry formulations is a common strategy approved by the US FDA. However, single-sugar…
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Therapeutic proteins often require needle-based injections, which compromise medication adherence especially for those with chronic diseases. Sublingual administration provides a simple and non-invasive alternative. Herein, two novel peptides (lipid-conjugated protamine and a protamine dimer) were…
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