Proteins

Abstract Lipid nanoparticles (LNPs) are of significant interest as delivery systems for various RNA therapeutics, not least due to their outstanding success in applications including the COVID-19 vaccines and the siRNA therapeutic Onpattro®. As LNPs consist of different lipids, the lipid…
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Abstract With a far longer stability than traditional emulsions, Pickering emulsion gels (PKEGs)—stabilized by solid particles—have proven highly efficient in a range of applications during recent years. Particles based on proteins or polysaccharides with distinctive amphiphilic structure are…
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Abstract Objective To evaluate the storage and in-use stability of a novel synthetic lung surfactant (SLS) excipient enhanced growth (EEG) powder formulation. Significance Aerosol delivery of surfactant formulations could address limitations of current instilled surfactant replacement therapy…
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Abstract Epigallocatechin gallate (EGCG), a bioactive polyphenol derived from Camellia sinensis, exhibits multimodal anticancer activity through mechanisms such as apoptosis induction, metastasis suppression, and chemoresistance reversal. Despite its therapeutic promise, clinical application is…
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Hydrogels in Drug Delivery See the new book, edited by Alejandro J. Paredes, Garry Laverty, Eneko Larrañeta, Ryan F. Donnelly. It covers the fundamental mechanisms of drug delivery from a hydrophilic matrix, breaks down interconnections between introductory theory and applied materials chapters and…
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Hydrogels in Drug Delivery See the new book, edited by Alejandro J. Paredes, Garry Laverty, Eneko Larrañeta, Ryan F. Donnelly. It covers the fundamental mechanisms of drug delivery from a hydrophilic matrix, breaks down interconnections between introductory theory and applied materials chapters and…
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Abstract Protein and peptide drugs (PPDs) are highly effective therapies for a wide range of diseases, including cancer, diabetes, and autoimmune disorders . However, delivering these drugs orally presents significant challenges. PPDs face substantial barriers to attaining oral bioavailability,…
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Abstract With continued interest in high concentration monoclonal antibody drug products to meet subcutaneous administration requirements, there is heightened attention on balancing protein-protein interactions, solution properties and overcoming instabilities such as increased in viscosity,…
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Abstract The aim of this study was to investigate the impact of phenol on the precipitation of bovine serum albumin (BSA) and human growth hormone (hGH), in the presence of other excipients frequently used in biological drugs for parenteral delivery. The focus of the study lieson incompatibilities…
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Peptide and protein (PP) therapeutics are highly specific and potent biomolecules that treat chronic and complex diseases. However, their oral delivery is significantly hindered by enzymatic degradation, instability, and poor permeability through the gastrointestinal (GI) epithelium, resulting in…
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