Pharma Excipients
Proteins
Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in…
Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities. KLEPTOSE® HPβCD (hydroxypropyl beta-cyclodextrin) has functioned as a stable…
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Preparation of antibody-loaded protein microbeads for pulmonary delivery via Shirasu porous glass…
Reversible protein precipitates (protein microbeads) have been developed using Shirasu porous glass (SPG) membrane emulsification. Microbeads have a mean size of a few micrometers (2–5 μm), and their formation is reversible upon rehydration. Their feasibility was examined as dry powders for…
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Parafilm® M and Strat-M® as skin simulants in in vitro permeation of dissolving microarray patches…
In vitro permeation studies play a crucial role in early formulation optimisation before extensive animal model investigations. Biological membranes are typically used in these studies to mimic human skin conditions accurately. However, when focusing on protein and peptide transdermal delivery,…
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Overcoming the Low-Stability Bottleneck in the Clinical Translation of Liposomal Pressurized…
Abstract
Currently, several types of inhalable liposomes have been developed. Among them, liposomal pressurized metered-dose inhalers (pMDIs) have gained much attention due to their cost-effectiveness, patient compliance, and accurate dosages. However, the clinical application of liposomal pMDIs…
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Effects of excipients on the interactions of self-emulsifying drug delivery systems with human blood…
Due to its versatility in formulation and manufacturing, self-emulsifying drug delivery systems (SEDDS) can be used to design parenteral formulations. Therefore, it is necessary to understand the effects of excipients on the behavior of SEDDS formulations upon parenteral administration, particularly…
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Chrono-tailored drug delivery systems: recent advances and future directions
Abstract
Circadian rhythms influence a range of biological processes within the body, with the central clock or suprachiasmatic nucleus (SCN) in the brain synchronising peripheral clocks around the body. These clocks are regulated by external cues, the most influential being the light/dark cycle,…
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Interactions between multifunctional pharmaceutical excipients and efflux pump for optimal drug…
Polymeric excipients ensure the site-specific delivery of the drug at the desired rate for a specified duration to achieve better efficacy. Pharmaceutical excipients were supposed to be pharmacologically inert, and must assure a controlled rate of delivery, an adjustable pharmacokinetic and…
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Recent advances of electrospray technique for multiparticulate preparation: Drug delivery…
Abstract
The electrospray (ES) technique has proven to be an effective and a versatile approach for crafting drug delivery carriers with diverse dimensions, multiple layers, and varying morphologies. Achieving the desired particle properties necessitates careful optimization of various experimental…
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Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor…
Abstract
Biotherapeutics exhibit high efficacy in targeted therapy, but their oral delivery is impeded by the harsh conditions of the gastrointestinal (GI) tract and limited intestinal absorption. This article presents a strategy to overcome the challenges of poor intestinal permeability by using a…
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De novo development of small cyclic peptides that are orally bioavailable
Abstract
Cyclic peptides can bind challenging disease targets with high affinity and specificity, offering enormous opportunities for addressing unmet medical needs. However, as with biological drugs, most cyclic peptides cannot be applied orally because they are rapidly digested and/or display low…
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