DC Excipients – A list of excipients for direct compression

Direct compression (DC) the fastest and most economic way to manufacture a tablet as it directly goes from powder mixing to tableting without any further production steps. It plays a key role in continuous manufacturing thanks to the high efficiency and the very small footprint in production. The excipients in use such as binders, lubricants and disintegrants are key elements for a successful DC process. Therefore specific excipients or special types of excipients have been developed to fulfill the needs of direct compression.

pharmaexcipients has put together a list of excipients for direct compression (DC excipients) incl. function and manufacturer. Please get in touch with us for any update or missing excipient we will gladly add it as soon as possible.

Commercial NameCompositionFunction / ApplicationManufacturer
A-TABAnhydrous dibasic calcium phosphateFiller, BinderInnophos
AceCelTM 12Microcrystalline CelluloseFiller, BinderSigachi
AceCelTM 102Microcrystalline CelluloseFiller, BinderSigachi
AceCelTM 112Microcrystalline CelluloseFiller, BinderSigachi
AceCelTM 200Microcrystalline CelluloseFiller, BinderSigachi
AceCelTM 302Microcrystalline CelluloseFiller, BinderSigachi
Advantose 100MaltoseFiller, BinderSPI Polyols
Advantose FS 95Fructose, starchChewable tabletsSPI Pharma
Anhydrous DTAnhydrous LactoseKerry
Anhydrous DT HVSieved Anhydrous Lactose DTKerry
ARBOCEL A 300Powdered CelluloseFillerJRS Pharma
Avicel CE-15Microcrystalline Cellulose, guar gumImprove mouthfeel for chewable tabletsDuPont
Avicel PH 102Microcrystalline CelluloseFiller, BinderDuPont
Avicel PH 200Microcrystalline CelluloseFiller, BinderDuPont
Avicel PH 200 LMMicrocrystalline CelluloseFiller, BinderDuPont
Barcroft CS 90Calcium Carbonate, starchSPI Pharma
Barcroft Premix StSPI Pharma
Barcroft USP 321Aluminium HydroxideSPI Polyols
Benecel K4M DCHydroxylpropylmethylcellulose, HPMC Controlled release matrix polymerAshland Specialty Ingredients
Benecel K15M DCHydroxylpropylmethylcellulose, HPMC Controlled release matrix polymerAshland Specialty Ingredients
Benecel K100M DCHydroxylpropylmethylcellulose, HPMC Controlled release matrix polymerAshland Specialty Ingredients
BonuCel® D 3 H 2910 Hydroxylpropylmethylcellulose, HPMCFiller, BinderBIOGRUND
BonuCel® D 6 H 2910 Hydroxylpropylmethylcellulose, HPMCFiller, BinderBIOGRUND
BonuTab®Fillers, binders, lubricants, pigments and dyesAll-in-one excipientBIOGRUND
CALCI-PRESS™ 90 SCalcium carbonateSeppic
CaptisolModified cyclodextrin Cydex, Lenexa, KS
Carbofarma GA10Calcium Carbonate, AcaciaResina Industriales SA.
Carbofarma GM11Calcium Carbonate, MaltodextrinResina Industriales SA.
Carbopol 71G NFCarbomer Homopolymer Type ALubrizol
Cellactose 80Cellulose, lactoseMeggle
CelocalMicrocrystalline Cellulose, calcium phosphateDuPont
CombiLacLactose & Microcrystalline CelluloseMeggle
CompactCel®Hydroxylpropylcellulose/NaCMC or PVP/NaCMCBinder, direct compressionBIOGRUND
CompactCel® LUBHydroxylpropylcellulose or MCC, oil/wax, vegetable rice extractBinder, Lubricant,
direct compression
BIOGRUND
CompactCel® MABSilicondioxide, Calciumcarbonate, MCC and/or TalcBinder, direct compressionBIOGRUND
CompactCel® SILSilicondioxide + Hydroxylpropylcellulose/NaCMC or PVP/NaCMCBinder, direct compressionBIOGRUND
CompactCel® TCSweetners, polymers, beta-cyclodextrin, celluloseBinder, direct compressionBIOGRUND
COMPACTROLCalcium SulfateFillerJRS Pharma
Compritol® 888 ATOGlyceryl dibehenateLubricant challenging pharmaceutical tabletsGattefossé
Compritol® E ATOGlyceryl dibehenateLucricant for challenging nutraceutical tabletsGattefossé
Compritol® HD 5Glyceryl dibehenateLucricant for water-dispersible tabletsGattefossé
DelafloCalcium sulphateDelaflo
Di-Cafosanhydrous dibasic calcium phosphateBudenheim
DI-CAFOS® A 150dicalcium phosphate anhydrous Filler / diluentBudenheim
DI-CAFOS® A 60dicalcium phosphate anhydrous Filler / diluentBudenheim
DI-CAFOS® D 160dicalcium phosphate dihydrate Filler / diluentBudenheim
Di-PacSucrose, dextrinAmerican Sugar
DirectTab NMicrocrystalline Cellulose, Tricalcium Phosphate and Guar Gum Readymix for Neutraceutrical applicationsSigachi
DirectTab ODTMicrocrystalline Cellulose, Mannitol, Silicon Dioxide, Croscarmellose Sodium ODT Sigachi
DirectTab PMicrocrystalline Cellulose, Silicon Dioxide, Talc, Croscarmellose Sodium Readymix for Direct compressionSigachi
DisintequikGranule of Spray dried lactose and croscarmellose sodium Kerry
Disintequik MCC 10Granule of Spray dried lactose 90% MCC10%Kerry
Disintequik MCC 25Granule of Spray dried lactose 75% MCC25%Kerry
Disintequik ODTGranule of: Lactose Monohydrate, NF/EP/JP
Mannitol, USP
Crospovidone, NF
Dextrose Monohydrate, NF
Oral disintegrating tablet mixKerry
DuraLac HLactose, anyhdrousMeggle
EMCOCEL 90 MMicrocrystalline CelluloseFiller, BinderJRS Pharma
EMCOCEL 90 M coarseMicrocrystalline CelluloseFiller, BinderJRS Pharma
EMCOCEL HD 90Microcrystalline CelluloseFiller, BinderJRS Pharma
EMCOCEL LP 200Microcrystalline CelluloseFiller, BinderJRS Pharma
EMCOCEL XLM 90Microcrystalline CelluloseFiller, BinderJRS Pharma
EMCOMPRESSDibasic Calcium Phosphate, DihydrateFillerJRS Pharma
EMCOMPRESS anhydrousDibasic Calcium Phosphate, anhydrousFillerJRS Pharma
EMCOMPRESS PremiumDibasic Calcium Phosphate, DihydrateFillerJRS Pharma
EMDEXDextrates, NFFiller-BinderJRS Pharma
EraTabStarchNational Starch
Eudragit RL and RSMethacrylica acid polymersEvonik
EXCIPRESS™GR150Lactose, granulatedFiller, BinderArmor Pharma
EXCIPRESS™SD2 Lactose, spray-driedFiller, BinderArmor Pharma
Fast flo 315,316Spray dried lactoseDirect compression where Great Flow is neededKerry
Finlac DCLactitolDanisco
FlowLac (90, 100)Lactose, spray-driedMeggle
Fujicalinanhydrous dibasic calcium phosphateFuji Chemicals
galenIQ 721IsomaltHigh soluble filler-binder for fast disintegration with great taste profileBENEO-Palatinit
galenIQ™ 720IsomaltDirect compressible filler-binder with great taste profileBENEO-Palatinit
Gohsenol EG-03 P, EG-05 PPolyvinylalcoholBinderNippon Gohsei Co., Ltd.
GRANFILLER-DMannitol, Microcrystalline Cellulose, Carmellose and CrospovidoneReadymix for Direct compressionDAICEL
HarkePlus TabMicrocrystalline Cellulose/HPC/Ca phosphateBinderHarke Pharma
Health in Gum, Types HiG PWD 01, HiG PWD 03, HiG PWD 0430% Gum base, Sorbitol, Xylitol, MannitolChewing Gum baseCafosa Gum S.A.U.
HiCelTM 12Microcrystalline CelluloseFiller, BinderSigachi
HiCelTM 90MMicrocrystalline CelluloseFiller, BinderSigachi
HiCelTM CE15Microcrystalline Cellulose & Guar GumImprove mouth feel of chewable tabletsSigachi
HiCelTM HD 90Microcrystalline CelluloseFiller, BinderSigachi
HiCelTM HFE 50MMicrocrystalline Cellulose & MannitolFiller, BinderSigachi
HiCelTM HFE 90MMicrocrystalline Cellulose & MannitolFiller, BinderSigachi
HiCelTM LP200Microcrystalline CelluloseFiller, BinderSigachi
HiCelTM SMCC 50MMicrocrystalline Cellulose & Colloidal Silicon DioxideFiller, BinderSigachi
HiCelTM SMCC 90MMicrocrystalline Cellulose & Colloidal Silicon DioxideFiller, BinderSigachi
HiCelTM SMCC HD90Microcrystalline Cellulose & Colloidal Silicon DioxideFiller, BinderSigachi
HiCelTM SMCC LM90Microcrystalline Cellulose & Colloidal Silicon DioxideFiller, BinderSigachi
HiCelTM XLM 90Microcrystalline CelluloseFiller, BinderSigachi
HiCelTM XLM 200Microcrystalline CelluloseFiller, BinderSigachi
HiSORADMannitol, Microcrystalline Cellulose and Croscarmellose sodiumReadymix for Direct compressionDAICEL
Klucel EXF HPCHydroxypropyl celluloseBinderAshland Specialty Ingredients
Klucel Nutra D HPCHydroxypropyl celluloseBinderAshland Specialty Ingredients
Kollidon Cl, CL-F, CL-SF, CL-MCrosslinked water-soluble PVPBASF
L-HPC: LH 21, L-HPC LH B1, L-HPC NBD-021Hydroxypropylcellulose ( HPC), low substitutedBinder with disintegration propertiesShin Etsu Chemial Co., Ltd.
Lubritose ANGranule of Anhydrous Lactose with GMSCo-processing of GMS creates lubrication properties that equal Magnesium Stearate but without the limitations typically encountered
Kerry
Lubritose ColourPotential to add colour to excipient (lactose, MCC or Mannitol)Co-processing of GMS creates lubrication properties that equal Magnesium Stearate but without the limitations typically encountered
Kerry
Lubritose MannitolSpray dried Mannitol with GMSCo-processing of GMS creates lubrication properties that equal Magnesium Stearate but without the limitations typically encountered
Kerry
Lubritose MCCGranule MCC with GMSCo-processing of GMS creates lubrication properties that equal Magnesium Stearate but without the limitations typically encountered
Kerry
Lubritose PlaceboSpray dried lactose, MCC and GMSCo-processing of GMS creates lubrication properties that equal Magnesium Stearate but without the limitations typically encountered
Kerry
Lubtitose SDGranule of Spray-dried lactose with GMSCo-processing of GMS creates lubrication properties that equal Magnesium Stearate but without the limitations typically encountered
Kerry
LudiflashMannitol, PVA, crospovidoneDirect compression ODTBASF
Magnipress 90 Magnesium carbonateSeppic
MaltrinMaltodextrinGPC
Mannogem 2080MannitolSPI Polyols
Methocel DC2HPMCDuPont
MicroceLacMicrocrystalline Cellulose, LactoseMeggle
Neosorb 60SorbitolRoquette
Nisso HPC SSL-SFPHydroxypropyl celluloseHighest efficiency Direct Compression binder. SSL means “Super Super Low” molecular weight for minimal impact on disintegration and dissolution. SFP means micronized “Super Fine Powder” for high specific surface area to maximize binding efficiency. Binding efficiency is 2-3x greater than traditional HPC/HPMC and 5x MCC.Nisso America
Nu-Tabsucrose, invert sugar, cornstarch and magnesium stearateColorcon
PanExaea MCC333GMicrocrystalline Cellulose, HPMC, PVPMallinckrodt Baker
PARTECK® CCS Croscarmellose SodiumFor use as Super disintegrant with superior disintegration performanceMerck KGa
Parteck® LUB CSTCalcium stearateFor use as lubricant with reliable performance through specified PSD and BETMerck KGa
Parteck®  LUB MSTMagnesium stearateFor use as lubricant with reliable performance through specified PSD and BETMerck KGa
Parteck® LUB STA 50 Stearic acidFor use as lubricant with reliable performance through specified PSD and BETMerck KGa
Parteck® M 100MannitolDirect compressible Mannitol with excellent binding properties and low content in reducing sugars for use as filler/binderMerck KGa
Parteck® M 200 MannitolDirect compressible Mannitol with excellent binding properties and low content in reducing sugars for use as filler/binderMerck KGa
Parteck® Mg DCMagnesium hydroxide carbonateDirect compressible inorganic filler/binder with large surface area. Also for use as API carrier.Merck KGa
Parteck® ODTMannitol + Croscarmellose-NaFor use as a filler/Binder in formulation of ODT-Tablets with excellent binding and disintegration properties and stabilityMerck KGa
Parteck® SI 150SorbitolDirect compressible Sorbitol with excellent binding properties and outstanding palatability for use as filler/binderMerck KGa
Parteck® SI 200SorbitolDirect compressible Sorbitol with excellent binding properties and outstanding palatability for use as filler/binderMerck KGa
Parteck® SI 400SorbitolDirect compressible Sorbitol with excellent binding properties and outstanding palatability for use as filler/binderMerck KGa
Parteck® SI 400 LEX SorbitolDirect compressible Sorbitol with excellent binding properties and outstanding palatability for use as filler/binder. Low in endotoxins.Merck KGa
Parteck® SLC 500 Silicon dioxideFunctional inorganic carrier with large specified surface area, for solubility
enhancement of poorly water soluble APIs; API-loaded carrier suitable for direct compression
Merck KGa
Parteck® SRP 80 Polyvinyl alcoholFunctional polymer for reliable sustained release matrix formulations in oral solids, with specified medium particle size, suitable für direct compressionMerck KGa
Pearlitol FlashMannitol, maize starchDirect compression ODTRoquette
Pearlitol SCGranulated MannitolRoquette
Pharm DC 93000StarchCerestar
Pharmacoat 603, 606Hydroxypropylymethylcellulose ( HPMC)BinderShin Etsu Chemial Co., Ltd.
Pharmatose DCL 40B-Lactose, lactitolDMV
Plasdone S630Vinyl acetate, vinyl pyrrodlidoneSPI Pharma
Polyplasdone XL corospovidoneDisintegrantAshland Specialty Ingredients
Polyplasdone XL 10 crospovidoneDisintegrantAshland Specialty Ingredients
Primecel 102, 302Microcrystalline CelluloseBinder, FillerChemfield Pharmaceuticals Pvt. Ltd.
PROSOLV 90 LMMCC, Colloidal Silicon DioxideFiller-BinderJRS Pharma
PROSOLV EASYtab NutraMCC, Colloidal Silicon Dioxide, Croscarmelose Sodium, Hydrogenated Plant Oil, DATEMAll-in-one excipient,
nutraceutical version
JRS Pharma
PROSOLV EASYtab SPMCC, Colloidal Silicon Dioxide, Sodium Starch Glycolate, Sodium Stearyl FumarateAll-in-one excipientJRS Pharma
PROSOLV ODT G2MCC, Colloidal Silicon Dioxide, Mannitol, Fructose, CrospovidoneODT platform JRS Pharma
PROSOLV SMCC 50MCC, Colloidal Silicon DioxideFiller-BinderJRS Pharma
PROSOLV SMCC 50 LDMCC, Colloidal Silicon DioxideFiller-BinderJRS Pharma
PROSOLV SMCC 90MCC, Colloidal Silicon DioxideFiller-BinderJRS Pharma
PROSOLV SMCC HD 90MCC, Colloidal Silicon DioxideFiller-BinderJRS Pharma
Puracal DCCalcium lactate pentahydratePurac
Puracal TPCalcium lactate trihydratePurac
PVP K 25, 30, 90PolyvinylpyrrolidonBinderHuangshan Bonsun Pharmaceuticals Co., Ltd.
PVPP PVPP-CL, PVPP-XL 10Cross linked PVPDisintegrantHuangshan Bonsun Pharmaceuticals Co., Ltd.
Ran Explo-CMicrocrystalline Cellulose, silica & crospovidoneRanQ
Ran Explo-SMicrocrystalline Cellulose, silica & SSGRanQ
Rediflo AGAgglomerated LactoseKerry
RetaLacLactose, HypromelloseDiffusion controlled DissolutionMeggle
RetardCel®Hypromellose, NaCMCRetardationBIOGRUND
SilSol 6035Silicon DioxideAPI carrier with controlled poresize and related high surface area, specially designed for solubility enhancement of BCS2-4; suitable for direct compressionGrace
SmartEx QD-50, QD-100Mannitol, PVA, HPC low substitutedODT TabletsShin Etsu Chemial Co., Ltd.
SorbogemSorbitolSPI Polyols
StarCap 1500Corn starch, pregelatinized starchFiller, disintegrantColorcon
StarLacLactose, starchFiller, disintegrantMeggle
Sucralose powder SucraloseHigh intensity sweetener. Micronized grade for tableting applicationsMerck KGa
Surfhope D1803Stearic acid ester, Palmitic acid ester LubricantMitsubishi Kagaku Foods Corporation
Syloid 63FPSilicon DioxideMoisture scavanger able to stabilise water in a formulation /API protection from chemical degradation due to water activityGrace
Syloid 244FSilicon DioxideFood grade multifunctional flow improver. While improving flow also taking care of charging, sticking, improving tablet hardness, avoiding physical degradation.Grace
Syloid 244FPSilicon DioxidePharma grade multifunctional DC flow improver. While improving flow and uniformity for DC also taking care of charging, sticking, improving tablet hardness, avoiding physical degradation. Stabilising suspension properties.Grace
Syloid AL1FPSilicon DioxideMoisture scavanger able to stabilise water in a formulation /API protection from chemical degradation due to water activityGrace
Syloid G Silicon DioxideFlow improvement onlyGrace
Syloid XDP 3050Silicon DioxideCarrier / Tabletting grade for liquisolid technologiesGrace
Tablettose (70, 80, 100)Lactose, agglomeratedFiller, BinderMeggle
TCC TBTricalcium citrate tetrahydrateFillerJungbunzlauer
Tri TabTricalcium phosphateFillerInnophos
VIVAPHARM PVP/VA 64CopovidoneBinderJRS Pharma
VIVAPUR 12Microcrystalline CelluloseFiller, BinderJRS Pharma
VIVAPUR 14Microcrystalline CelluloseFiller, BinderJRS Pharma
VIVAPUR 102Microcrystalline CelluloseFiller, BinderJRS Pharma
VIVAPUR 102 SCGMicrocrystalline CelluloseFiller, BinderJRS Pharma
VIVAPUR 112Microcrystalline CelluloseFiller, BinderJRS Pharma
VIVAPUR 200Microcrystalline CelluloseFiller, BinderJRS Pharma
VIVAPUR 200 XLMMicrocrystalline CelluloseFiller, BinderJRS Pharma
VIVAPUR 302Microcrystalline CelluloseFiller, BinderJRS Pharma
Xylitab 100Xylitol, polydextroseDanisco
Kolliphor® P 188, P 407 MicroMicronized PoloxamerLubricantBASF
Kolliphor® SLS FineSodium Lauryl SulfateLubricantBASF
Ludipress® Lactose, povidone, crospovidone Three-in-one system for direct compressionBASF
Ludipress® LCELactose, povidoneReady-to-use direct compression solution for lozenges, chewables and effervescent tabletBASF