Carbomer

Abstract Vaginal drug delivery has gained significant interest due to its numerous advantages, such as good blood flow, bypassing the first-pass effect, low systemic side effects, and potential for sustained release of pharmaceuticals. Initially targeting contraception and local effects from…
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Abstract Recent advances in pH-responsive drug delivery systems have demonstrated their promising potential for targeted therapeutic delivery. However, challenges remain in developing platforms that combine precise spatiotemporal control with robust mechanical properties. Herein, we present a novel…
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Abstract Vesicular systems have demonstrated efficacy in the management of Rheumatoid Arthritis (RA). This study explores the synergistic effect of edge-activated ethosomal gel to enhance the transdermal delivery of Curcumin (CUR) and Cyclosporine (CYC). Ethosomal vesicles prepared via the ethanol…
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Abstract The hydrogels with methylene blue (MB), based on selected synthetic and semisynthetic polymers (SP), doped with citrate starch (CS), was evaluated successfully in the terms of MB release from polymeric matrix with prolonged release effect. The hydrophilic matrix in the hydrogel systems…
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Abstract Background: Current research aims to fabricate carboxymethyl cellulose sodium (CMC-Na) and carbopol hydrogel beads. Gleichzeitig, beads were coated with chitosan to enhance the controlled release of the drug Metformin HCl (MET), which serves as a model drug for diabetes mellitus (DM).…
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Abstract The purpose of the current study was to examine the immune response of sheep given the Rift Valley Fever virus vaccination adjuvanted with Carbopol®. Fifteen sheep were divided into three groups of five each. The first group received the ALOH adjuvanted inactivated RVF vaccination. The…
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Abstract Polaprezinc (PLZ) has drawn attention to its potential to prevent oral mucositis caused by chemotherapy and radiotherapy. PLZ-containing lozenges have been developed in previous reports; however, for patients with mucositis, taking them may be challenging because of pain. Therefore, this…
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Abstract Background: Various routes of drug administration are available for psoriasis treatment. However, there is an urgent need for novel and improved therapeutic options. Hence, our study aimed to develop a nanostructured lipid carrier (NLC) gel of hesperidin (HPD) using a systemic QbD approach…
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Abstract Background: Rheumatoid arthritis is a chronic autoimmune disease that leads to severe disability and requires improved therapeutic strategies to optimize anti-inflammatory treatment. This study aimed to address this challenge by developing and characterizing an extended-release polymer…
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Abstract The current study presents a comprehensive pharmaceutical engineering approach to developing an advanced transdermal drug delivery system for addressing skin hyperpigmentation through innovative nanocomposite gel formulation. Utilizing a systematic Quality-by-Design (QbD) methodology with…
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