Magnesium Stearate

Abstract The development of a robust oral solid dosage form requires knowledge of all the sources of variation that could impact the dosage form’s performance and stability, in line with Quality-by-Design (QbD). This requires a deep understanding of the relationships between raw material…
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Abstract Metformin is a relatively old drug mainly used to treat type 2 and gestational diabetes, which needs to be administered two or three times a day in high doses. It has a high aqueous solubility and is poorly absorbed following oral intake. Aiming to achieve a gastroretentive formulation for…
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Abstract The present study focuses on the development and optimization of a solid self-microemulsifying drug delivery system (SSMEDDS) of Nateglinide, a poorly water-soluble antidiabetic drug, to enhance its oral bioavailability. Initially, a liquid SMEDDS was formulated using Capmul MCM as the…
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Abstract Material-sparing tablet development (MSTD) describes an approach to tablet formulation development that uses the active pharmaceutical ingredient's (API) material properties to guide formulation design. The work presented here expands on this methodology and demonstrates its application…
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Abstract Over the past decades, a variety of controlled-release technologies have been developed to maintain a constant drug release rate in vivo. Osmotic pumps offer precise control and are widely used in marketed formulations. However, the manufacturing of osmotic pump tablets often involves…
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Abstract Nitrosamine impurities have garnered recent attention due to their presence in pharmaceuticals and their mutagenic risks. Recent studies have emphasized controlling impurities and suggest ways to mitigate the further formation of nitrosamines by the addition of antioxidants to tablets and…
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Reimagining the future of coatings without TiO₂. Titanium dioxide (TiO₂) has long been the go-to for perfectly white tablet coatings. But with growing regulatory scrutiny and consumer demand for cleaner labels, drug manufacturers could use a reliable alternative. Scientists at Roquette set out to…
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Abstract Aim: The study aimed to develop a once-daily sustained-release gastroretentive combination formulation of bepotastine besilate and montelukast sodium using multilayer tablet technology and gastro-retentive systems for the treatment of allergic rhinitis and asthma. Background:…
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Abstract 3D printing offers a promising approach to creating personalized medicines. However, costly, expertise-dependent trial-and-error methods hinder efficient drug formulation, posing challenges for tailoring treatments to individual patients. To address this, a novel pipeline is developed for…
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Abstract Compression analysis is essential for the investigation of materials and processes in the manufacturing of pharmaceutical tablets. In the past, the influence of various process parameters on compression analysis has been investigated. The strength of these influences can significantly…
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