Magnesium stearate, also known as magnesium octadecanoate, is a common additive used in the pharmaceutical industry. It is a white, odorless, and tasteless powder that is highly insoluble in water, but soluble in organic solvents.
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Magnesium Stearate
Dissolve Pain in Seconds: The Advantage of F-MELT®in Lornoxicam Fast Disintegrating Tablets
Introduction
Revolutionizing Pain Relief for Rheumatoid Arthritis (RA)
Lornoxicam, a potent NSAID, is widely used for rapid pain relief in rheumatoid arthritis. However, its poor water solubility (BCS II) and bitter taste have historically limited its effectiveness in fast disintegrating tablet…
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Deep learning-based image classification and quantification models for tablet sticking
Abstract
Sticking can significantly affect drug product quality, manufacturing efficiency, and therapeutic efficacy in pharmaceutical tablet manufacturing. This study presents a novel integrated model with a convolutional neural network (CNN) and gray-level co-occurrence matrix (GLCM) based…
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Impact of pharmaceutical tablet properties on optical porosimetry performance
Abstract
The porosity of a pharmaceutical tablet influences liquid transport, disintegration and dissolution, rendering its monitoring and control crucial for quality by design. Optical porosimetry, a non-destructive process analytical technology (PAT), combines gas in scattering media absorption…
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Spray Dried Lubricants Offering Enhanced Flowability
Introduction
There are several approaches in order to develop tablet formulations. On the one hand, high functionality excipients that follow the concept “API+1” offer many advantages like easier handling, higher compactability and they combine synergistic effects. In addition, they eliminate the…
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Expediting 3D printed medication development using vacuum compression moulding
Abstract
Three-dimensional printing (3DP) is a disruptive technology for producing medications tailored to individual patients, with fused-deposition modelling (FDM) being one of the most established technologies for clinical implementation. However, obtaining FDM pharma-ink (drug-loaded filaments…
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Comparative study of Hot-Melt Extrusion, spray drying, and KinetiSol® processing to formulate a…
Abstract
Fenbendazole (FBZ), a benzimidazole-carbamate anthelmintic, shows promising chemotherapeutic properties. However, it is a poorly water-soluble molecule, leading to low and variable oral bioavailability. This study investigated hot-melt extrusion (HME), spray drying, and KinetiSol…
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Effect of additives and operating conditions on tablet weight variation: Analysis based on powder…
Abstract
The flowability and compressibility of powders during tableting are crucial for determining the quality of pharmaceutical products. Although silicon compounds are additives that improve compressibility, their type and addition ratio could impair flowability. Therefore, formulation and…
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Formulation and In Vitro Evaluation of Matrix Tablets Containing Ketoprofen–Beta Cyclodextrin…
Abstract
Background: Rheumatoid arthritis is a chronic autoimmune disease that leads to severe disability and requires improved therapeutic strategies to optimize anti-inflammatory treatment. This study aimed to address this challenge by developing and characterizing an extended-release polymer…
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From Oral to Sublingual: A Redefined Avanafil Tablet with a Breakthrough in Bioavailability and…
Abstract
Introduction
Avanafil (AVA) is a very efficient phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction. However, it has limited bioavailability when taken orally and considerable first-pass metabolism. Enhancing its solubility and choosing an alternative delivery…
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Does tablet shape and height influence survival of fluidized bed-granulated living microorganisms…
Abstract
The provision of effective probiotic formulations requires gentle processing to maintain the viability of the probiotic microorganisms, which is essential for their health-promoting effects. The drying of microorganisms by fluidized bed spray granulation and subsequent processing of the…
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