Oils have been used by the pharmaceutical industry for decades. From parenteral nutrition to soft gel formulations, oils play a key role in a wide range of pharmaceutical products. With an ever increasing number of new drug candidates with poor aqueous solubility and poor oral bioavailability, oils are very attractive candidates to solve real challenges for the formulators.
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Pharmaceutical Oils
Nanostructured lipid carriers as a drug delivery system: A comprehensive review with therapeutic…
Abstract
Recent advances in nanotechnology have enabled significant developments in health through innovative drug delivery systems. Nanostructured lipid carriers (NLCs) have emerged as a key technology in this field, offering enhanced drug stability, improved loading capacity, and reduced drug…
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Development and Characterization of Olaparib-Loaded Solid Self-Nanoemulsifying Drug Delivery System…
This study aims to enhance the solubility of Olaparib, classified as biopharmaceutical classification system (BCS) class IV due to its low solubility and bioavailability using a solid self-nanoemulsifying drug delivery system (S-SNEDDS). For this purpose, SNEDDS formulations were created using…
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Solid Self Nano-Emulsifying Drug Delivery System of Dasatinib: Optimization, In-vitro, Ex-vivo and…
Abstract
Aim: Dasatinib (DST) is an oral tyrosine kinase inhibitor with poor aqueous solubility. To outwit this issue, a solid self-nano emulsifying drug delivery system (S-SNEDDS) of DST was formulated.
Methods: I-optimal mixture design was used for optimization of DST-loaded SNEDDS using…
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Unraveling the Impact of the Oil Phase on the Physicochemical Stability and Skin Permeability of…
Abstract
Melatonin’s antioxidant properties make it a valuable component in anti-aging semisolid topical products. This study explores the role of Pemulen®, an acrylic-based viscosifying agent, in stabilizing cream-gel formulations. Remarkably, even at low concentrations (0.4%), Pemulen® …
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The Ultimate Guide to Soft Gelatin Capsule Manufacturing
Producing soft gelatin capsules (softgels) involves meticulous attention to detail and a deep understanding of the materials and processes. In this article, we will delve into the critical aspects of fill material production, exploring techniques to ensure uniformity, the importance of equipment,…
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Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with…
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should…
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Optimizing Softgel Fill Formulation: Key Considerations
Softgel capsules are a popular dosage form for pharmaceuticals and supplements, offering benefits like improved bioavailability and ease of swallowing. However, creating effective softgel formulations, especially for suspensions (pastes), involves complex considerations. This article explores these…
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Unlocking the Potential of Softgel Capsules: Types and Formulations
Softgel capsules are a popular choice for delivering a wide range of compounds, from pharmaceuticals to nutritional supplements. Their versatility and efficacy hinge on the type of fill material used. Let's explore the three primary types of fills for softgel capsules: Single Oil or Oil Mixtures,…
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Transformative solidification techniques for self-emulsifying drug delivery and its foresight in…
Abstract
Self-emulsifying drug delivery systems (SEDDSs) represent a significant breakthrough in addressing bioavailability
challenges by enhancing the solubilization of poorly water-soluble drugs, ensuring consistent formulation properties,
and facilitating easy industrial scale-up. Despite…
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Labrafac MC60 is an efficacious intestinal permeation enhancer for macromolecules: Comparisons with…
Labrafac™ MC60 (glycerol monocaprylocaprate) is a lipid-based excipient used in oral formulations as a solubiliser. Due to the high proportions of established permeability enhancers, caprylate (C8) and caprate (C10), in Labrafac™ MC60, we hypothesised that it might behave as an intestinal permeation…
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