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Phospholipids
Drug delivery as a sustainable avenue to future therapies
Climate change and the need for sustainable, technological developments are the greatest challenges facing humanity in the coming decades. To address these issues, in 2015 the United Nations have established 17 Sustainable Development Goals. Anthropogenic climate change will not only affect everyone…
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Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases
Diseases affecting the anterior segment of the eye are the primary causes of vision impairment and blindness globally. Drug administration through the topical ocular route is widely accepted because of its user/patient friendliness - ease of administration and convenience. However, it remains a…
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PHOSAL® H 50: Liquid Phospholipids Derived from Sunflower
The Natural All-Rounder
Lipoid’s PHOSAL® H 50 is a liquid formulation of purified phosphatidylcholine (PC) and oil from 100 % sunflower. This unique, pure and natural liquid formulation can serve as a solubilizer for lipophilic actives and can help to disperse lipid phases into aqueous systems by…
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Fabrication, assessment, and optimization of alendronate sodium nanoemulsion-based injectable…
Low bone mass, degeneration of bone tissue, and disruption of bone microarchitecture are all symptoms of the disease osteoporosis, which can decrease bone strength and increase the risk of fractures. The main objective of the current study was to use a phospholipid-based phase separation in-situ gel…
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Incorporating a Lipophilic Disulfide-Bridged Linoleic Prodrug into a Self-Microemulsifying Drug…
The oral absorption of paclitaxel (PTX) is restricted by poor solubility in the gastrointestinal tract (GIT), low permeability, and high first-pass metabolism. Lipid carriers, such as a self-microemulsifying drug delivery system (SMEDDS), have been deemed as promising vehicles for promoting oral…
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Tailored anti-biofilm activity – Liposomal delivery for mimic of small antimicrobial peptide
The eradication of bacteria embedded in biofilms is among the most challenging obstacles in the management of chronic wounds. These biofilms are found in most chronic wounds; moreover, the biofilm-embedded bacteria are considerably less susceptible to conventional antimicrobial treatment than the…
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Formulating elafibranor and obeticholic acid with phospholipids decreases drug-induced association…
Chronic hepatic diseases often compromise liver function and are directly responsible for up to two million yearly deaths world-wide. There are yet no treatment options to solve this global medical need.
Experimental drugs elafibranor (Ela) and obeticholic acid (OA) appeared promising in numerous…
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Self-nano Emulsifying Formulations: An Encouraging Approach for Bioavailability Enhancement and…
Abstract
Currently lipid-based formulations are playing a vital and promising role in improving the oral bioavailability of poorly water-soluble drugs. Lipid based formulations mainly consist of a drug dissolved in lipids such as triglycerides, glycerides, oils and surface active agent.…
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Phospholipids in Pharmaceutical Form Line Extensions
The pharmaceutical industry has two main ways to generate new products. The first option is to look for new drug substances. A second option is to employ better formulations of an existing drug product. Such reformulated products are called Pharmaceutical Form Line Extensions. As part of such a…
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Biocompatible phospholipid-based mixed micelles for posaconazole ocular delivery: Development,…
Current study intended to prepare and evaluate phospholipid-based, mixed micelles (MMs) to improve the ocular delivery of posaconazole (POS), a broad-spectrum antifungal drug. For this, MMs based on egg phosphatidylcholine (EPC), as the main component, in combination with various bile salts (sodium…
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