Browsing Category
Polylacticcoglycolic acid – PLGA
Fabrication of porous polymeric microneedles: A concise overview
Abstract
Recent advancements in microneedle (MN) technology have increasingly focused on porous polymeric microneedles (PPMNs), which are, among various types of MN, emerging as a promising platform for diverse biomedical applications, including transdermal drug delivery, interstitial fluid (ISF)…
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3D-Printed cannabidiol stent for local treatment of urinary tract infections
Abstract
Urinary tract infections (UTIs) are highly prevalent among women and those assigned female at birth, and frequently necessitate the administration of systemic antibiotics, which contributes to the antibiotic resistance crisis due to overuse and suboptimal patient adherence. This study…
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PLGA Implants for Controlled Drug Delivery and Regenerative Medicine: Advances, Challenges, and…
Abstract
Poly(lactide-co-glycolide) (PLGA) implants have become a cornerstone in drug delivery and regenerative medicine due to their biocompatibility, tunable degradation, and capacity for sustained, localized therapeutic release. Recent innovations in polymer design, fabrication methods, and…
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Unlocking the potential of remdesivir: innovative approaches to drug delivery
Abstract
Given the recurrent waves of COVID-19 and the emergence of new viral infections, optimizing the potential of remdesivir as an antiviral agent is critical. While several reviews have explored the efficacy of remdesivir, few have comprehensively addressed its challenges, such as the…
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Design and Development of PLGA -Hollow Mesoporous Silica Nanoparticles for Injectable Micro-…
Abstract
Addressing the challenges of drug delivery in osteoarthritis (OA), this study explores a novel approach using Metformin (Met) encapsulated within poly(lactide-co-glycolide) (PLGA) microspheres containing hollow mesoporous silica nanoparticles (HMSN). By leveraging a flow-focusing…
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PLGA/TPGS nanoparticles for docetaxel delivery: the pegylation effect on nanoparticle…
Abstract
Prostate cancer is the most common malignancy in men worldwide and docetaxel (DTX) is the treatment of choice. However, both the drug and formulation excipients for drug solubilization can cause side effects. In this context, the development of polymeric nanoparticles offers advantages…
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In-situ forming solvent-induced phase inversion (SIPI) implants for controlled drug delivery: role…
In recent years, there has been a surge of research focused on in situ-forming implants as a method of localized drug delivery. Despite advancements, the predominant challenge in situ-forming solvent-induced phase inversion (SIPI) implants is significant burst release which typically occurs within…
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PLGA-Based Strategies for Intranasal and Pulmonary Applications
Abstract
Poly(D,L-lactide-co-glycolide) (PLGA) has emerged as a cornerstone in the development of advanced drug delivery systems, particularly for intranasal and pulmonary routes. Its biodegradability, biocompatibility, and adaptability make it an ideal platform for addressing challenges associated…
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Amphotericin B PLGA nanoparticles loaded dissolving microneedle patches in treating cutaneous fungal…
Abstract
Cutaneous fungal infections pose a significant health challenge, particularly in deeper skin layers where topical treatments are ineffective. Amphotericin B (AmB) is the gold standard for treating fungal infections, but its poor solubility limits its transdermal delivery. In this work, AmB…
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Innovative bioinks for 3D bioprinting: Exploring technological potential and regulatory challenges
Abstract
The field of three dimensional (3D) bioprinting has witnessed significant advancements, with bioinks playing a crucial
role in enabling the fabrication of complex tissue constructs. This review explores the innovative bioinks that are
currently shaping the future of 3D bioprinting,…
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