Polylacticcoglycolic acid – PLGA

Abstract The recent advancement of 3D-printed drugs is an emerging technology that has the potential for effective and safe oral delivery of personalized treatment regimens to patients, replacing the current “one size fits all” philosophy. The objective of this literature review is to highlight the…
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Abstract Vaginal drug delivery has gained significant interest due to its numerous advantages, such as good blood flow, bypassing the first-pass effect, low systemic side effects, and potential for sustained release of pharmaceuticals. Initially targeting contraception and local effects from…
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Abstract The incorporation of poorly soluble active ingredients, which make up the majority of the molecules in development, into fixed-dose combination (FDC) products can be an efficient method to improve the pharmacokinetic properties of these compounds, as well as reduce the side effects and…
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Abstract Drug delivery products based on poly(lactic-co-glycolic acid) (PLGA) often have multiphasic drug release profiles with slow “lag phase(s)” and rapid “burst phase(s),” which can limit therapeutic efficacy. The purpose of this study was to develop voriconazole (VCZ)/PLGA intravitreal…
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Abstract Recent advancements in microneedle (MN) technology have increasingly focused on porous polymeric microneedles (PPMNs), which are, among various types of MN, emerging as a promising platform for diverse biomedical applications, including transdermal drug delivery, interstitial fluid (ISF)…
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Abstract Urinary tract infections (UTIs) are highly prevalent among women and those assigned female at birth, and frequently necessitate the administration of systemic antibiotics, which contributes to the antibiotic resistance crisis due to overuse and suboptimal patient adherence. This study…
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Abstract Poly(lactide-co-glycolide) (PLGA) implants have become a cornerstone in drug delivery and regenerative medicine due to their biocompatibility, tunable degradation, and capacity for sustained, localized therapeutic release. Recent innovations in polymer design, fabrication methods, and…
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Abstract Given the recurrent waves of COVID-19 and the emergence of new viral infections, optimizing the potential of remdesivir as an antiviral agent is critical. While several reviews have explored the efficacy of remdesivir, few have comprehensively addressed its challenges, such as the…
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Abstract Addressing the challenges of drug delivery in osteoarthritis (OA), this study explores a novel approach using Metformin (Met) encapsulated within poly(lactide-co-glycolide) (PLGA) microspheres containing hollow mesoporous silica nanoparticles (HMSN). By leveraging a flow-focusing…
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Abstract Prostate cancer is the most common malignancy in men worldwide and docetaxel (DTX) is the treatment of choice. However, both the drug and formulation excipients for drug solubilization can cause side effects. In this context, the development of polymeric nanoparticles offers advantages…
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