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Polymers
Solubility improvement of curcumin by crystallization inhibition from polymeric surfactants in…
To improve the solubility and maintain the amorphous state of BCS Ⅳ drug by preparing surfactant solid dispersions, solid dispersions of curcumin (CUR) with TPGS and HPMC were prepared by solvent method. The synthesized solid dispersions were characterized by scanning electron microscopy, powder…
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Co-processed Hydroxypropyl Methylcellulose – Mannitol as a Directly Compressible Excipient for…
Introduction
Controlled release dosage forms deliver an effective dose of the active pharmaceutical ingredient over a prolonged duration, which is particularly advantageous to maintain a constant plasma drug concentration within the therapeutic window. This effectively overcomes the negative…
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Investigation of the degradation and in-situ amorphization of the enantiomeric drug escitalopram…
Hot-melt extrusion (HME) and subsequent FDM 3D printing offer great potential opportunities in the formulation development and production of customized oral dosage forms with poorly soluble drugs. However, thermal stress within these processes can be challenging for thermo-sensitive drugs. In this…
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Tubercular Drug Delivery Systems – Advances in Treatment of Infectious Diseases – Part…
The new book "Tubercular Drug Delivery Systems - Advances in Treatment of Infectious Diseases" book targets new advances in areas of treatment and drug delivery sciences for tuberculosis. It covers advances in drug therapy and drug targeting that focus on innovative trend defining technologies…
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Antisolvent Eudragit® polymers based in situ forming gel for periodontal controlled drug delivery
In situ forming gel (ISG) is relevant for periodontal pocket drug delivery because of its local administration with sustained drug release. Various types of 25% w/w Eudragit®-based ISG in different solvents were prepared for 5% w/w doxycycline hyclate (DH) loading. All Eudragit® types could be…
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Tubercular Drug Delivery Systems – Advances in Treatment of Infectious Diseases – Part…
The new book "Tubercular Drug Delivery Systems - Advances in Treatment of Infectious Diseases" book targets new advances in areas of treatment and drug delivery sciences for tuberculosis. It covers advances in drug therapy and drug targeting that focus on innovative trend defining technologies and…
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What is a tablet? Explainer video by PharmaDrama
Tablets are the most common pharmaceutical dosage form - but why, and what are they?
In this video PharmaDrama aka Prof. Simon Gaisford discusses what tablets are, what they contain, how they are made and how you should take them. He also looks at polymer (enteric) coats and how they are used to…
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Moisture sorption by polymeric excipients commonly used in amorphous solid dispersions and its…
Moisture sorption by polymeric carriers used in amorphous solid dispersion (ASD) plays a critical role in the physical stability of the dispersed drug as it can increase molecular mobility of drug in ASD by decreasing the glass transition temperatures (Tg) of the drug-polymer system, leading to drug…
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Investigating the Influence of HPMC K4M and Eudragit L 100-55 on Guanfacine-Loaded Extended-Release…
This study aims to optimize the concentrations of hydroxypropyl methyl cellulose (HPMC) K4M and Eudragit L100- 55 (methacrylic acid) in formulation of extended-release tablets containing guanfacine hydrochloride by employing a 32 -factorial design approach. Extended-release tablets of guanfacine…
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Unlock the Potential of Poorly Soluble Drugs with Apisolex™ Technology
Don’t let poor solubility affect your innovative drug projects
Approximately 60% of potential active pharmaceutical ingredients (APIs) under development, and more than 40% of those in reformulation, are poorly water soluble1. Solubility challenges present a substantial hurdle to the development…
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