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Polymers
Hydrogels in Drug Delivery – Part 1
Hydrogels in Drug Delivery
See the new book, edited by Alejandro J. Paredes, Garry Laverty, Eneko Larrañeta, Ryan F. Donnelly. It covers the fundamental mechanisms of drug delivery from a hydrophilic matrix, breaks down interconnections between introductory theory and applied materials chapters and…
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Advances in the Oral Delivery of Protein and Peptide Drugs
Abstract
Protein and peptide drugs (PPDs) are highly effective therapies for a wide range of diseases, including cancer, diabetes, and autoimmune disorders . However, delivering these drugs orally presents significant challenges. PPDs face substantial barriers to attaining oral bioavailability,…
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Recent developments in nanofiber-based fast-disintegrating drug delivery systems
Abstract
Introduction
Fast-disintegrating electrospun fibers are emerging as innovative systems for oral drug delivery. These fibers possess a high surface area, porosity, and customizable hydrophilicity, which facilitates quick drug release by disintegrating rapidly in biological fluids or upon…
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A universal digital control concept for end-to-end manufacturing
Abstract
With the implementation of advanced manufacturing concepts (e.g., continuous operation, integration of different process routes and modular manufacturing), control of the process and the related product quality becomes more complex. Unlike traditional in-process controls and end-product…
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PLGA Implants for Controlled Drug Delivery and Regenerative Medicine: Advances, Challenges, and…
Abstract
Poly(lactide-co-glycolide) (PLGA) implants have become a cornerstone in drug delivery and regenerative medicine due to their biocompatibility, tunable degradation, and capacity for sustained, localized therapeutic release. Recent innovations in polymer design, fabrication methods, and…
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A porridge-like hydrogel promoted the oral bioavailability of veterinary medicines
Abstract
The administration of veterinary medicines via drinking water or feed ingredients is a widely adopted method in intensive livestock and poultry farming due to its convenience and cost-effectiveness. Among these drugs, antimicrobials are extensively used, with over 70% of global…
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PredicDiff™: a computational tool for the prediction of PERLs concentrations based on extractables…
Abstract
PredicDiff™, a computational modeling tool that allows fitting diffusion curves to process equipment related leachables (PERLs) is presented. Based on the measurement of extractables (analytical data), Fick’s second law of diffusion, and a Trust Region Rebounds based fitting algorithm…
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Sex-specific formulations of doxazosin mesylate via direct powder extrusion 3D printing
Abstract
Males and females are known to exhibit significant differences in drug pharmacokinetics and pharmacodynamics, which are still overlooked in pharmaceutical research and development. These disparities contribute to adverse effects and increased mortality in females, highlighting the critical…
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Pullulan as a sustained release carrier for ocular drug delivery: a review
Abstract
Pullulan, an exopolysaccharide, obtained from the fungus Aureobasidium pullulans, is a non-ionic, hydrophilic, biodegradable, biocompatible, and tolerogenic polymers that is used for the formulation of bioconjugates in the therapeutic delivery to target different cells and tissues. It is…
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Treatment of ulcerative colitis by sustained release curcumin pellets coated with ethyl ascorbic…
Abstract
The present work aimed to protect the rapid reduction of Curcumin (Cur) in alkaline pH by newly synthesized ethyl ascorbic acid (EAA) in dual-coated Cur pellets (CCur-P4d) used for the treatment of inflammatory bowel disease (IBD). Physicochemical and morphological analysis was performed…
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