Polymers

The aim of this study was to formulate and evaluate mucoadhesive sodium alginate microspheres for nasal administration of Pentoxifylline to avoid first-pass metabolism. Microspheres were prepared using an ionic gelation process using a 23 -factorial design. We investigated the effects of several…
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Abstract The tableting process involves the conversion of mechanical to thermal energy. This study evaluated the influence of temperature on the tableting behavior of formulations with different compositions. The tableting machine was equipped with a thermally controlled die to mimic the heat…
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Abstract In this review, we have highlighted different types of Pluronic® polymers for prominent photodynamic therapy (PDT) applications. To begin with, we have provided the definition and mechanism of PDT and enumerate its advantages over other frequently used therapeutic modalities. We have also…
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The pH-sensitive polymers have attained significant attention in the arena of targeted drug delivery (TDD) because of their exceptional capability to respond to alteration in pH in various physiological environments. This attribute aids pH-sensitive polymers to act as smart carriers for therapeutic…
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Introduction Film coating of solid dosage forms in pharmaceutical manufacturing is carried out using range of equipment, process parameters and coating formulations to achieve the quality target profile of the dosage form. Besides for aesthetic reasons, film coatings are mostly applied to modify…
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The research work aimed to develop a robust sustained release biocompatible brinzolamide (BRZ)-loaded ocular inserts (MeltSerts) using hot-melt extrusion technology with enhanced solubility for glaucoma management. A 32 rotatable central composite design was employed for the optimization of the…
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Helicobacter pylori is a gram-negative, spiral-shaped, flagellated bacterium that colonizes the stomach of half the world’s population. Helicobacter pylori infection causes pathologies of varying severity. Standard oral therapy fails in 15–20% since the barriers of the oral route decrease the…
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The objectives of this study were to evaluate the delamination of convex-shaped metformin HCl (MF) and evogliptin tartrate (EG) multi-layer tablets depending on the pre-compression and main compression pressures and simultaneously correlate these results with those of a surface roughness analysis.…
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Lipid and/or polymer-based drug conjugates can potentially minimize side effects by increasing drug accumulation at target sites and thus augment patient compliance. Formulation factors can present a potent influence on the characteristics of the obtained systems. The selection of an appropriate…
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Abstract Dual centrifugation (DC) is an innovative in-vial homogenization and in-vial nanomilling technique that has been in use for the preparation of liposomes for more than one decade. Since then, DC has continuously been developed for preparing various liposomes and other lipid nanoparticles…
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