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Polyvinyl Alcohol – PVA
3D Printing in Oral Drug Delivery: Technologies, Clinical Applications and Future Perspectives in…
Abstract
The recent advancement of 3D-printed drugs is an emerging technology that has the potential for effective and safe oral delivery of personalized treatment regimens to patients, replacing the current “one size fits all” philosophy. The objective of this literature review is to highlight the…
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Fabrication and Ex-vivo Evaluation of Olanzapine Nanoparticles Based Dissolved Microneedle for…
Abstract
Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for treatment of schizophrenia, it possesses poor oral bioavailability (60%) due to low solubility and first-pass hepatic metabolism. Hence, the aim of present work is to fabricate and evaluate an olanzapine…
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Controlled release of amitriptyline via the transdermal route using SmartReservoirs and…
Abstract
SmartReservoirs (SRs) are novel drug reservoirs made from a cellulose-based matrix for hydrogel-forming microneedles (HF-MNs). SRs can incorporate drug molecules within a cellulose-based matrix in amorphous form. This significantly improves the solubility of poorly soluble drugs, which…
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Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs
Abstract
The safety of repeated microarray patch (MAP) application is crucial for its development as an innovative drug delivery platform. This study is the first to assess the safety of repeated applications of hydrogel-forming, dissolving, and implantable MAPs over four weeks using miniature…
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Application of Biomaterials in the Development of Enteric-Coated Luminar Capsule Microneedles for…
Abstract
In commercial applications, sofosbuvir (SOF) for hepatitis C is only available in tablet dosage form, resulting in minimal SOF accumulation in the liver (26.94%) due to its low intestinal permeability and high molecular weight (529.5 Da). Therefore, in this study, luminar capsule…
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Super-fast production of drug nanocrystals: Dual asymmetric centrifugation-enabled media milling…
Abstract
Drug nanocrystals (NCs) have entirely changed the panorama of drug delivery, enabling enhanced drug absorption and long-acting drug release. The vast majority of marketed NCs-based products are obtained via media milling using of-the-shelf industrial machinery. However, early-stage…
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Novel ethosomal gel formulation for enhanced transdermal delivery of curcumin and cyclosporine: a…
Abstract
Vesicular systems have demonstrated efficacy in the management of Rheumatoid Arthritis (RA). This study explores the synergistic effect of edge-activated ethosomal gel to enhance the transdermal delivery of Curcumin (CUR) and Cyclosporine (CYC). Ethosomal vesicles prepared via the ethanol…
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Quercetin-Eudragit® polymer complexes with enhanced loading, solubility, stability, and…
Abstract
Aim
Quercetin is a natural dietary compound known for its potential to prevent chronic diseases. However, the translation of this success to humans is hindered due to quercetin’s poor oral bioavailability, attributed to its extremely low water solubility and permeability. These…
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Application of Lactose Co-Processed Excipients as an Alternative for Bridging Pharmaceutical Unit…
Abstract
Improving the manufacturability of drug formulations via direct compression has been of great interest for the pharmaceutical industry. Selecting excipients plays a vital role in obtaining a high-quality product without the wet granulation processing step. In particular, for diluents which…
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Biosurfactant Stabilized Nanosuspension of KRAS inhibitor – Sotorasib (AMG-510): Systematic…
Abstract
This research study aimed to develop and evaluate a novel freeze-dried nanocrystals formulation of sotorasib (AMG-510) using Quality by Design (QbD) approach to enhance solubility, dissolution, and oral bioavailability. A QbD framework use for identification, optimization and validation of…
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