Polyvinyl Alcohol – PVA

Transepidermal microneedle-assisted drug delivery is an alternative approach that can improve the therapeutic permeability of the drug in the deeper layers of the skin. The project aims to check the effect of a microneedle roller on transepidermal delivery of Iloperiodone across the neonatal porcine…
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Ophthalmic drug formulations are growing in importance due to the increased prevalence of eye-related disorders such as diabetic retinopathy and macular degeneration.1 However, ocular drug delivery is challenging due to unique anatomical and physiological barriers such as pre-corneal loss factors…
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Abstract A solid lipid nanoparticle provides the opportunity of developing new therapies due to their unique size-dependent characteristics. They are a small particle that ranges between 1-100 nm in size. Lipid nanoparticles have risen in popularity in this context due to their widespread…
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The role of microneedle array patches (MAPs) and, in particular, dissolving MAPs in transdermal drug delivery has increased exponentially over the last decade. MAPs are able to form drug depots in the viable skin from where poorly soluble drugs dissolve in a long-acting fashion, showing promise in…
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Spray drying is a promising technology for drying lipid nanodispersions. These formulations can serve as carrier systems for poorly water-soluble active pharmaceutical ingredients (APIs) that are loaded into the lipid matrix to improve their bioavailability. Once the API-loaded nanocarriers have…
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The potential of the mucoadhesive film technology is hard to ignore, owing to perceived superior patient acceptability versus buccal tablets, and significant therapeutic opportunities compared to conventional oral drug delivery systems, especially for those who suffer from dysphagia. In spite of…
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Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota…
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BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1–4 ng/mL) and so require solubility enhancement. Therefore, ITZ and Kollidon® VA64 (KOL) amorphous solid dispersions (ASDs) were produced using hot-melt extrusion (HME) to improve ITZ’s poor solubility. A novel strategy for…
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The miscibility of the therapeutic drug in the polymer matrix is the key to the successful design and development of orodispersible films (ODFs). In the present study, four hydrolyzed polyvinyl alcohols (PVAs) with identical polymerization degree were investigated as carriers for Amlodipine (AML)…
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Reduce risk and overcome challenges Ophthalmic drugs pose special formulation challenges to manufacturers. In general, choosing the right processes and materials is important to ensure the required quality, drug tolerability and patient adherence. Formulators must pay attention to tonicity, pH,…
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