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Solvent
Combination of time-dependent polymer and inulin as a coating for sustained delivery of budesonide…
Crohn's disease and ulcerative colitis, both forms of inflammatory bowel disease (IBD), are prevalent conditions. Budesonide, a medication widely recommended as a first-line treatment for Crohn's disease, necessitates the development of formulations capable of delivering the drug to the intestinal…
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Development of Simvastatin-Loaded Particles Using Spray Drying Method for Ex Tempore Preparation of…
In this work, a spray drying method was developed to produce drug/polymer (simvastatin/polycaprolactone) microparticles that have the potential to be used as a pre-formulation for ex tempore preparation of 2D printing cartridges. An experimental model was designed with the process parameters set to…
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Influence of Manufacturing Process on the Microstructure, Stability, and Sensorial Properties of a…
The manufacturing process for ointments typically involves a series of heating, cooling, and mixing steps. Precise control of the level of mixing through homogenization and the cooling rate, as well as temperature at different stages, is important in delivering ointments with the desired quality…
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Spray drying robot for high-throughput combinatorial fabrication of multicomponent solid dispersions
During the development of pharmaceutical spray-dried formulations, many samples must be prepared for physico-chemical characterisation and dissolution testing by systematically varying parameters such as drug loading or the grades and ratios of excipients (polymers, surfactants, etc.). When spray…
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The balance of physical stability and drug release in ternary fenofibrate/HPC/Eudragit L100-55…
Introduction
Amorphous solid dispersions are state-of the art enabling technique for poorly water soluble active pharmaceutical ingredients (APIs). In an ASD, the API is molecularly dissolved in a suitable polymer matrix that stabilizes the amorphous state during storage against recrystallization…
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Raw Materials – Practical Pharmaceutics Part 1
An International Guideline for the Preparation, Care and Use of Medicinal Products
See the new book, edited by Paul Le Brun, Sylvie Crauste-Manciet, Irene Krämer, Julian Smith, Herman Woerdenbag:
Description: Practical Pharmaceutics contains essential knowledge on the preparation, quality…
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Rational Design of Topical Semi-Solid Dosage Forms – How Far Are We?
Specific aspects of semi-solid dosage forms for topical application include the nature of the barrier to be overcome, aspects of susceptibility to physical and chemical instability, and a greater influence of sensory perception. Advances in understanding the driving forces of skin penetration as…
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PLGA – A versatile copolymer for design and development of nanoparticles for drug delivery
Introduction
Poly (lactic-co-glycolic acid) or PLGA, a highly hydrophobic copolymer comprised of lactic acid and glycolic acid, has been approved in many drug products and medical devices.1 Over the years since the first approved in 1997, PLGA has been widely studied polymer in the industry because…
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Impact of Amylose-Amylopectin Ratio of Starches on the Mechanical Strength and Stability of…
The two main components of starch — amylose and amylopectin, are responsible for its interaction with moisture. This study investigated how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. The starch samples…
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Long-acting Parenteral Drug Delivery Systems for the Treatment of Chronic Diseases
Abstract
The management of chronic conditions often requires patients to take daily medication for an extended duration. However, the need for daily dosing can lead to nonadherence to the therapy, which can result in the recurrence of the disease. Long-acting parenteral drug delivery systems have…
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