Bioavailability enhancement

Abstract Permeation enhancers (PE) such as hyaluronidase are increasingly incorporated into subcutaneous (SC) biologic drug formulations to improve drug absorption....

Abstract Purpose Ustekinumab, targeting interleukin (IL)-12 and IL-23, is effective in treating chronic immune-mediated inflammatory diseases, but needs to be...

Abstract Excipients, historically regarded as inert, are now being recognised for their ability to actively modulate biological targets, including intestinal...

Abstract Hesperidin, a flavanone, exhibits antioxidant, anti-inflammatory, and anti-amyloidogenic properties, making it a promising candidate for the treatment of Alzheimer's...

Abstract Parkinson’s disease (PD) is frequently complicated by dysphagia, undermining timely and reliable oral dopaminergic medication. Levodopa’s short half-life and...

Abstract Background/Objectives: The ABCG2 transporter actively effluxes anticancer drugs, reducing their efficacy and promoting multidrug resistance (MDR). Developing oral formulations...

Abstract Introduction This study explores the emulsification behavior and oral delivery performance of dry and wet inverted lipid phases (ILPdry and...

Abstract The limited aqueous solubility of numerous active pharmaceutical ingredients (APIs) remains a major barrier to achieving optimal oral bioavailability,...

  Lipid excipients offer a unique combination of benefits Poor solubility, poor permeability, and pre-systemic elimination are factors that can...

Abstract The present study aimed to design, optimize, and evaluate enteric-coated nanocarriers to enhance the oral bioavailability of Rifaximin, a...