Bioavailability enhancement

Abstract Oral metformin is the most prescribed therapy for type 2 diabetes mellitus, nevertheless, the bioavailability remains low and variable....

Abstract Hesperetin (HSP), a naturally occurring citrus flavanone with diverse antioxidant, anti-inflammatory, and pharmacological activities, has attracted considerable attention as...

Abstract Poor aqueous solubility is a major cause of solubility-limited absorption and misleading pharmacokinetic outcomes during early oral drug discovery....

Abstract Despite various attempts at solubility enhancement and advances in formulation technologies, improving the bioavailability of poorly water-soluble compounds remains...

Abstract Cannabidiol (CBD) exhibits poor oral bioavailability (approximately 6%) due to low solubility and excessive first-pass metabolism, limiting its therapeutic...

Abstract Background: The therapeutic potential of many natural products, including curcumin (CUR), betulinic acid (BA), and oleanolic acid (OA), is limited...

IOI Oleo launched a new family of functional, lipid-based excipients, the polyglycerol esters at CPhI 2025. As the CPhI 2026...

A significant proportion of new drug candidates present limited aqueous solubility. This is a well-documented formulation challenge, particularly for oral...

Abstract Aceclofenac (ACF) is a commonly used non-steroidal anti-inflammatory drugs (NSAID) for numerous inflammatory conditions; however, its therapeutic potential is...

Abstract Propolis is a widely studied natural raw material, the composition of which varies depending on the plant origin, harvest...