Bioavailability enhancement

Abstract α-Lipoic acid (LA), a naturally occurring antioxidant and anti-inflammatory agent, has limited aqueous solubility and bioavailability which hinders its clinical application. To overcome these limitations, in this study, we have developed LA solid dispersion (LASD) using soluplus (SOL) to…
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Abstract This research study aimed to develop and evaluate a novel freeze-dried nanocrystals formulation of sotorasib (AMG-510) using Quality by Design (QbD) approach to enhance solubility, dissolution, and oral bioavailability. A QbD framework use for identification, optimization and validation of…
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Abstract Inflammatory skin diseases are chronic conditions that significantly affect patients’ skin health and quality of life. Traditional treatments, including systemic immunosuppressants and topical therapies, often face limitations such as low efficacy, inadequate skin penetration, and severe…
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Abstract Epigallocatechin gallate (EGCG), a bioactive polyphenol derived from Camellia sinensis, exhibits multimodal anticancer activity through mechanisms such as apoptosis induction, metastasis suppression, and chemoresistance reversal. Despite its therapeutic promise, clinical application is…
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What is Phosphatidylcholine? Phosphatidylcholine is the fat-soluble form of the vitamin-like substance choline and an important phospholipid for the human body. The molecule consists of a water-soluble choline head and two fat-soluble fatty acids including polyunsaturated ones.…
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Abstract Exenatide, a first-in-class GLP-1 receptor agonist, is used to control glycaemic levels in type 2 diabetes. There are two approved injectable formulations: one solution for immediate action and one dispersion for prolonged action. Oral exenatide has low bioavailability due to poor…
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Introduction Revolutionizing Pain Relief for Rheumatoid Arthritis (RA) Lornoxicam, a potent NSAID, is widely used for rapid pain relief in rheumatoid arthritis. However, its poor water solubility (BCS II) and bitter taste have historically limited its effectiveness in fast disintegrating tablet…
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Abstract Protein and peptide drugs (PPDs) are highly effective therapies for a wide range of diseases, including cancer, diabetes, and autoimmune disorders . However, delivering these drugs orally presents significant challenges. PPDs face substantial barriers to attaining oral bioavailability,…
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Abstract Nanotechnology has revolutionised pharmaceutical sciences, with mesoporous silica nanoparticles (MSNs) extensively studied as drug carriers. However, their clinical translation is hindered by challenges such as toxicity, tumour accumulation, and uncontrolled endocytosis. Mesoporous silica…
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Abstract Solid eutectic mixtures of self-dispersible polyethylene glycol-40-stearate with fenofibrate or ibuprofen—prepared by casting or by twin-screw extrusion—were compared in terms of processability and dissolution rate at, below, and above the eutectic concentration. Furthermore, the effects…
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