Bioavailability enhancement

Abstract Lipid-based formulations (LBFs) offer a promising strategy to enhance the oral bioavailability of poorly water-soluble drugs, such as biopharmaceutical...

Abstract Cyclodextrins (CDs) are cyclic oligosaccharides made up of α-(1 → 4)-linked d-glucopyranose units and are generally obtained by enzymatic conversion of...

Abstract Oral bioavailability (%F) is a key determinant of drug efficacy and a critical decision-making parameter in early-stage drug development....

Abstract Background A dihydrofolate reductase inhibitor, pyrimethamine has an emerging anticancer potential but is not well soluble in aqueous and...

Abstract Bio-adhesive buccal-delivery of drugs is one of alternative to the oral route of drug administration, particularly drugs that are...

Abstract Diabetes mellitus currently affects an estimated 635 million individuals worldwide. Insulin therapy remains the primary treatment option for patients...

Abstract Oral metformin is the most prescribed therapy for type 2 diabetes mellitus, nevertheless, the bioavailability remains low and variable....

Abstract Hesperetin (HSP), a naturally occurring citrus flavanone with diverse antioxidant, anti-inflammatory, and pharmacological activities, has attracted considerable attention as...

Abstract Poor aqueous solubility is a major cause of solubility-limited absorption and misleading pharmacokinetic outcomes during early oral drug discovery....

Abstract Despite various attempts at solubility enhancement and advances in formulation technologies, improving the bioavailability of poorly water-soluble compounds remains...