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Bioavailability enhancement
Fujicalin®: Revolutionizing Axitinib Delivery with Liquisolid Technology
Introduction
Axitinib (AXT), a second-generation inhibitor of vascular endothelial growth factor receptors (VEGFR), is used in the treatment of advanced renal cell carcinoma (RCC). Despite its efficacy, AXT's clinical application is limited by its poor aqueous solubility and bioavailability,…
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The Impact of Polymers on Enzalutamide Solid Self-Nanoemulsifying Drug Delivery System and Improved…
Abstract
Enzalutamide (ENZ), marketed under the brand name Xtandi® as a soft capsule, is an androgen receptor signaling inhibitor drug actively used in clinical settings for treating prostate cancer. However, ENZ’s low solubility and bioavailability significantly hinder the achievement of optimal…
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Ritonavir loaded solid lipid nanoparticles for oral drug delivery and bioavailability enhancement
Abstract
Background
Ritonavir is an anti-retroviral protease inhibitor to treat HIV, AIDS infections.
Methods
The RN-SLNs were prepared by using hot homogenization followed ultrasonication method and optimized by using a two-factor, three-level central composte design (CCD). The independent…
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Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and…
Abstract
Resins are complex mixtures of natural constituents containing non-volatile and volatile terpenes, in combination with gums and polyphenols, used since ancient times for their medicinal properties. Current research has evidenced their therapeutic value with a plethora of activities. The…
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4D printing of shape-memory polymer-based floating tablets via fused deposition modelling:…
Abstract
The integration of four-dimensional (4D) printing technology into pharmaceutical manufacturing has introduced a transformative approach to drug delivery systems, offering flexible alternatives to improve drug bioavailability. This study advanced the field by developing an innovative…
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Sustained-Release Solid Dispersions of Fenofibrate for Simultaneous Enhancement of the Extent and…
Abstract
Background/Objectives: A sustained-release formulation of fenofibrate while enhancing drug dissolution with minimal food effect is critical for maximizing the therapeutic benefits of fenofibrate. Therefore, this study aimed to develop an effective solid dispersion formulation of…
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Monosodium Glutamate: The Ultimate Cell Culture Booster for Your Bioproduction Processes
Sodium L-glutamate, better known as Monosodium glutamate (MSG) by Dr. Paul Lohmann® , has emerged as a crucial component in bioproduction processes, particularly in the cultivation of certain microorganisms, significantly enhancing biopharmaceutical processes.
Applications in growth media…
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Development and optimization of polymeric nanosponges for enhanced delivery of diflunisal in…
Abstract
Rheumatoid arthritis damages the synovial membrane, and diflunisal, a nonsteroidal anti-inflammatory drug (NSAID) with poor solubility, faces delivery challenges. Nanosponges enhance diflunisals solubility improving its bioavailability; in addition it improved its stability and controls…
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Formulation and Evaluation Oral Dispersible Tablets of Vibegron
Abstract
In the present work, taste masking of Vibegron was carried out by using strong cation exchange resin tulsion 344. These taste-masked complexes were further formulated into the Oro dispersible tablet by the direct compression method using Ac-Di-Sol and Avicel as a super disintegrant.…
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Effects of micellar media on the bioavailability, solubility, and stability of curcumin
Abstract
Curcumin (CUR), a polyphenolic pigment of turmeric, -possess biological and medicinal properties. Regardless of having a wide range of therapeutic applications, CUR’s poor bioavailability, owing to its meagre solubility and stability, limits its application from being used as a…
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