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Bioavailability enhancement
Vitamin E & TPGS Reimagined: ADM’s Novatol® and Decanox® Solutions
The sky’s the limit with ADM’s Novatol® naturally derived Decanox® mixed tocopherols and vitamin E. These powerful and plant-based antioxidants are the ideal way to help protect cells in the body from oxidative stress. Further, Novatol® vitamin E is twice as effective as synthetic vitamin E…
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Simplex Lattice Design and Machine Learning Methods for the Optimization of Novel Microemulsion…
Novel p-coumaric acid microemulsion systems were developed to circumvent its absorption and bioavailability challenges. Simplex-lattice mixture design and machine learning methods were employed for optimization. Two optimized formulations were characterized using in vitro re-dispersibility and…
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Co-release of paclitaxel and encequidar from amorphous solid dispersions increase oral paclitaxel…
The oral bioavailability of paclitaxel is limited due to low solubility and high affinity for the P-glycoprotein (P-gp) efflux transporter. Here we hypothesized that maximizing the intestinal paclitaxel levels through apparent solubility enhancement and controlling the simultaneous release of both…
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Simple preparation and greatly improved oral bioavailability: The supersaturated drug delivery…
Quercetin, as a representative flavonoid, is widely present in daily diet and has been developed as a dietary supplement due to its beneficial physiological activities. However, the application of quercetin is limited due to its poor water solubility and extensive metabolism. So far, the nano-drug…
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Supersaturable diacyl phospholipid dispersion for improving oral bioavailability of brick dust…
This study aims to investigate the potential use of polymer inclusion in the phospholipid-based solid dispersion approach for augmenting the biopharmaceutical performance of Aprepitant (APT). Initially, different polymers were screened using the microarray plate method to assess their ability to…
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Optimization of Hydroxypropyl Methylcellulose (HPMC) and Carbopol 940 in Clindamycin HCl Ethosomal…
Clindamycin HCl has anti-acne properties because it can inhibit the growth of Propionibacterium acnes (P. acnes) bacteria. However, the bioavailability of clindamycin HCl is less than 13% of the given dose, so it needs to be developed in the form of ethosomes to increase its bioavailability. This…
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SEPITRAP™ offers new possibilities for formulation and improving the bioavailability of active…
Description
SEPITRAP™ is a micro-encapsulated solubilizer in powder form designed to simplify the manufacturing of solid oral form drugs. It is manufactured by adsorption of the solubilizer in liquid form on a porous support.
SEPITRAP™ is both a solid solubilizer and a compression agent.…
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3D-Printed Lipid Mesophases for the Treatment of Chronic Liver Disease
Abstract
Although lipid-based formulations are an attractive approach for enhancing the oral bioavailability of lipophilic drugs, their addition into solid oral dosage forms has been proven challenging due to their high viscosity and heat sensitivity. Therefore, unlike the traditional tableting…
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Self-microemulsifying system of an ethanolic extract of Heliopsis longipes root for enhanced…
Abstract
Self-microemulsifying or self-nanoemulsifying drug delivery systems (SMEDDS/SNEDDS) are well known to improve the dissolution and increase the oral bioavailability of hydrophobic drugs, including herbal extracts. Organic extracts of Heliopsis longipes root and affinin, its main component,…
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Third-Generation Solid Dispersion Through Lyophilization Enhanced Oral Bioavailability of…
Resveratrol (RES) is a biopharmaceutical classification system (BCS) class II compound with low solubility and high permeability. Several strategies have been explored to overcome the low bioavailability of RES, making the formation of solid dispersions (SDs) one of the most promising. This study…
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