Bioavailability enhancement

Abstract Background/Objectives: Cannabinoids are increasingly recognised for their therapeutic potential beyond well-established indications such as chronic pain, multiple sclerosis, and specific...

Abstract Poor tablet hardness and drug re-crystallization are two common challenges of amorphous solid dispersion (ASD) formulations prepared with hot-melt...

Introduction Weakly Basic Drugs and the Role of Acidic Microenvironments Weakly basic drugs benefit from acidic environments. These drugs represent...

Abstract The aim of this study was to develop a once-daily controlled-release (CR) apixaban (APX) formulation that enhances bioavailability through...

Abstract Mangiferin, a natural bioactive compound with multiple physiological functions, faces limitations in its oral bioavailability due to poor stability...

Abstract Background: Buccal administration offers direct access to systemic circulation, improving drug bioavailability when compared with the conventional oral route....

Abstract Permeation enhancers (PE) such as hyaluronidase are increasingly incorporated into subcutaneous (SC) biologic drug formulations to improve drug absorption....

Abstract Purpose Ustekinumab, targeting interleukin (IL)-12 and IL-23, is effective in treating chronic immune-mediated inflammatory diseases, but needs to be...

Abstract Excipients, historically regarded as inert, are now being recognised for their ability to actively modulate biological targets, including intestinal...

Abstract Hesperidin, a flavanone, exhibits antioxidant, anti-inflammatory, and anti-amyloidogenic properties, making it a promising candidate for the treatment of Alzheimer's...