Capsules

ABSTRACT Oral administration of medicine is one of the most common delivery routes still in use today. Various dosage forms are administered via the oral route including tablets, capsules, syrups, solutions and emulsions. Tablets constitute a large part of orally available dosage forms due to ease…
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Application of essential oils in modern medicine has a limited use due to its specific physico-chemical properties which can make them extremely unsuitable for the formulation of stable pharmaceutical forms. The aim of this study was to develop robust hard capsules formulation with natural essential…
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An International Guideline for the Preparation, Care and Use of Medicinal Products See the new book, edited by Paul Le Brun, Sylvie Crauste-Manciet, Irene Krämer, Julian Smith, Herman Woerdenbag: Description: Practical Pharmaceutics contains essential knowledge on the preparation, quality…
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Abstract Objective To demonstrate the applicability of a novel micro-dosing system for precisely filling low powder doses (down to a few mg) into capsules along with weighing the filled powder mass accurately. Methods Ten commonly used pharmaceutical powders, ranging from cohesive…
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Lisinopril (LIS) it is antihypertensive drug, classified as a class III drug with a high water solubility and low permeability. To overcome the low permeability, 32 factorial designs aimed to formulate LIS as a sustained-release (LIS-SR) matrix pellet by extrusion/spheronization. Matrix pellets were…
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Kollicoat® Smartseal 30 D and Kollicoat® Smartseal 100 P can help formulators tackle challenges when handling bitter active ingredients. It offers superior protection from unpleasant drug taste for minitablets, pellets, particles, and granules used in orally disintegrating dosage forms, improving…
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Introduction Gelatin has been used as shell polymer in the manufacture of soft gelatin capsules (softgels) for about the past century. Its rheological and thermal properties offer adequate balance for subsequent process steps including gel solution preparation/transportation, film casting, and…
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Hyaluronic acid can modify porous starch through cross-linking and hydrogen bonding, effectively achieving a paclitaxel entrapment efficiency of ∼92 % and drug loading of ∼23 %. In this study, the pores and intergranular gaps of porous starch were filled with paclitaxel under solvent volatilization,…
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Tertiary lactose has been shown to improve aerosolization performance of carrier-based dry powder inhalation formulations. The working mechanism of the tertiary lactose, however, is still unclear, even the optimal working condition of the lactose fines. Two strategies to incorporate the tertiary…
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Phage therapy is recognized to be a promising alternative to fight antibiotic-resistant infections. In the quest for oral dosage forms containing bacteriophages, the utilization of colonic-release Eudragit® derivatives has shown potential in shielding bacteriophages from the challenges encountered…
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