SPI Pharma

Superior pharmaceuticals with unparalleled application expertise

High performance functional excipients and actives, specialized taste-masking technology and high-efficiency vaccine adjuvants.

Company Profile

At SPI Pharma, we don’t just make ingredients, we help deliver better health. From everyday wellness to life-saving vaccines, our innovations in excipients, actives, and drug delivery systems help customers bring essential treatments to patients across the globe.

• Deep expertise in formulation science
• Relentless focus on quality, safety, and service
• A passion for improving people’s lives

We help customers bring life-changing therapies to market — faster, safer, and with confidence to improve the quality of people’s lives

For more than 75 years, we’ve been a trusted partner delivering innovative excipient solutions and active ingredients that improve the quality of life for patients everywhere.

From concept to commercialization, SPI Pharma provides technical expertise and a global supply network to support faster, more reliable product development. Our mission is to make a difference through patient-friendly, life-changing medicines.

Products

COMPRESSOL™ ProTab (NEW!)

Compressol ProTab is a multifunctional soluble excipient platform designed for direct compression (DC). It’s built to solve complex formulation challenges – especially where traditional excipients fall short.

Whether you’re working with high-dose APIs, pressure-sensitive actives, fragile coated pellets (MUPS), or live probiotic strains, Compressol ProTab delivers consistent performance, stability, and manufacturability across a wide range of tablet formats.

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Valens™ AH 2.0 (NEW!)

Valens AH 2.0 is a high-performance aluminium hydroxide adjuvant engineered for human vaccines.

With 2% aluminium oxide, a positive surface charge for efficient antigen adsorption, and compatibility with other components to stimulate additional immune pathways, Valens™ AH 2.0 enhances antibody-mediated immune responses. It offers sterilized, scalable, cGMP- and Ph.Eur-compliant production you can trust, with flexible packaging and volumes for your vaccine programs.

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Actimask™ Acetaminophen

SPI Pharma’s advanced taste-masking solution for acetaminophen or paracetamol, engineered to deliver a pleasant mouthfeel and high API loading – ideal for chewables, ODTs, sachets, and stick packs. Designed to improve patient compliance and streamline formulation development.

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Advantose™ 100

Advantose 100 is a spray-dried maltose powder that provides excellent flow, solubility, and tableting properties for oral dosage formulations. Maltose is well known for its safety and mouthfeel qualities, especially in chewable tablets and lozenges.

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UltraBurst™

Introducing UltraBurst, a novel, innovative excipient platform for ODTs. Delivering the fastest disintegration time of any preformulated products on the market while maintaining best in class hardness, friability, and API loading.

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Pharmasperse™

Pharmasperse 416 is a versatile drug delivery system comprised of excipients that meet globally accepted compendia. This innovative platform can create patient friendly formulations.

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Pharmaburst™ 500

Pharmaburst was the first orally disintegrating tablet (ODT) platform on the market. Pharmaburst 500 is the current standard for its performance and versatility. It is an ideal choice among formulators because it addresses development challenges and creates premium products. It is a co-processed excipient platform meeting globally accepted compendia and is used in over 60 commercialized products worldwide.

Sorbitol Special™

Sorbitol Special plasticizers are sorbitan-sorbitol based soft gel plasticizers. They enhance the capsule finish gloss for a premium appearance, help to prevent leakage, provide consistent pharmaceutical quality, and extend shelf life by maintaining a proper moisture balance within the capsule shell.

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DC Sugars

Maltose and Fructose have been used successfully in a variety Food, Pharma, and Nutraceutical products. SPI Pharma has created a unique form of these sugars. Advantose 100 Maltose and Advantose FS95 Fructose improve flow for these materials. As a result, these useful ingredients gain versatility and are easily incorporated into formulations for pharmaceutical and nutraceutical tablet products.

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Mannogem™ Mannitol

Your team works hard to create a product that patients want to take. Selecting an excipient that makes their job easier and the patient experience better can be a challenge. Improve the patient experience and benefit from efficient manufacturing operations by formulating with Mannogem Mannitol.

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Find all SPI Pharma products in the shop:

SHOP ALL SPI PRODUCTS HERE

Key Product Categories & Highlights

• Excipients for Oral Solid Dose
  Comprehensive portfolio including mannitol, sorbitol, MCC, calcium carbonate, and specialty excipients designed for superior compressibility, disintegration, and taste masking.
• Drug Delivery Systems
  Fast-dissolving platforms and multiparticulate systems that enhance bioavailability and patient compliance.
• Vaccine Adjuvants
  Proven aluminum-based adjuvants and formulation expertise supporting global vaccine development and manufacturing.
• Nutraceutical Solutions
  Functional ingredients and formulation expertise supporting stable, consumer-friendly supplement products.

Adding Value to Pharmaceutical Products

For over 75 years, we have supplied the pharmaceutical industry with highly engineered products and innovative solutions that improve the formulation and delivery of drug products to meet patient needs. Our functional excipients and active ingredients meet the highest-quality standards possible and can offer customized, cost-effective options for many applications. We invite you to explore our product offerings. Our global technical team of experts can also help you select the right product to solve your formulation challenge.

Brochures

Making a Difference In Your Formulation

Pharmaburst® 500

Directly Compressible Sugars

Contact

SPI Pharma
123 Justison Street, Suite 115
Wilmington, DE 19801, USA

📞 +1 302-576-8552
✉️ [email protected]
🌐 www.spipharma.com