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Crospovidone
Lignin as a Bioactive Additive in Chlorzoxazone-Loaded Pharmaceutical Tablets
Abstract
In the present work, the application of lignin (LIG) as a bioactive additive for the preparation of drug-loaded tablets by direct compression has been studied, and its influence on the release of chlorzoxazone (CLZ) from the hydrophilic matrices has been followed. In hydrophilic matrices,…
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Evaluation of Calibration Burden for Monitoring of a Pharmaceutical Continuous Manufacturing Line…
Abstract
Process analytical technology (PAT) tools are an important part of process monitoring and control in pharmaceutical continuous manufacturing (CM) that help ensure product quality. However, there is hesitancy to adopt PAT due, in part, to the high start-up costs. A portion of the cost is…
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3D Printing of Tailored Veterinary Dual-Release Tablets: A Semi- Solid Extrusion Approach for…
Abstract
Metoclopramide (MCP) is frequently used to control nausea and vomiting in animals, but its short half-life requires it to be administered thrice daily. In addition, commercial veterinary MCP formulations are currently lacking. As a result,
veterinary practitioners often resort to…
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Scale-independent solid fraction prediction in dry granulation process using a gray-box model…
Abstract
We propose a novel approach for predicting the solid fraction after roller compaction processes. It is crucial to predict and control the solid fraction, as it has a significant impact on the product quality. The solid fraction can be theoretically predicted by a first-principles model…
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Development of tablet formulations containing genistein solid dispersion optimized using Box-Behnken…
Abstract
Genistein, a bioactive isoflavone, offers therapeutic potential but is hindered by poor water solubility, limiting its oral bioavailability. This study aimed to enhance genistein’s solubility by developing solid dispersion (SD) and formulating them into tablets. The SDs were prepared using…
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Investigating the Influence of Crospovidone’s Manufacturer Variability on Dissolution Profiles of…
Abstract
This study examines the influence of crospovidone (CP) manufacturer variability on the dissolution profiles of hydrochlorothiazide (HCTZ) tablets. Four CP batches from different manufacturers were characterized using pharmacopeial and physicochemical tests, including infrared absorption,…
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Advances in Taste-Masking Strategies for Pediatric Brain-Related Disease Treatments: Focus on…
Abstract
Pediatric treatment of brain-related diseases often requires oral medications, where palatability is crucial for patient adherence and therapeutic success. The unpleasant taste of many drugs, especially those used in neurological or psychiatric conditions, can reduce compliance in…
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Particle-based investigation of excipients stability: the effect of storage conditions on moisture…
Abstract
Moisture sensitivity poses a challenge in formulating oral dosage forms, particularly when considering disintegrants’ swelling due to prior moisture exposure, impacting performance and physical stability. This study utilises dynamic vapour sorption to simulate real-world storage scenarios,…
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Impact of disintegrants on rheological properties and printability in SSE 3D printing of…
Abstract
This study investigates the effects of disintegrants sodium starch glycolate (SSG) and crospovidone (CP) on the printability, rheological properties, and disintegration time of agar and hydroxypropyl methylcellulose (HPMC)-based formulations designed for semi-solid extrusion. Printability…
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Excipients in drug delivery systems: A comprehensive review of approved inactive ingredients for…
Abstract
Pharmaceutical excipients, commonly known as inactive ingredients, encompass any substance aside from the active ingredient that fulfills a distinct and vital role in a formulation. Their purpose is to enhance specific characteristics, whether associated with the performance of the…
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