Cyclodextrin

Abstract Introduction Avanafil (AVA) is a very efficient phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction. However, it has limited bioavailability when taken orally and considerable first-pass metabolism. Enhancing its solubility and choosing an alternative delivery…
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Abstract Cyclodextrins (CDs) play a crucial role in pharmaceutical formulations due to their unique ability to form inclusion complexes with a wide range of lipophilic drugs. Ternary complexes comprising CD, water-soluble polymer, and drug molecule have emerged as promising multicomponent to the…
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Abstract In the spirit of circular economy and sustainable chemistry, the use of environmentally friendly chemical products in pharmacy has become a hot topic. In recent years, organic solvents have been the subject of a great range of restriction policies due to their harmful effects on the…
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Abstract Background/Objectives: Curcumin has well-established efficacy in a variety of disorders due to its prominent antioxidant, antiaging, anti-inflammatory, chemosensitizing, and anticancer activities. Despite its numerous benefits, curcumin exhibits low bioavailability mainly due to its poor…
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Abstract As the global demographic shifts toward an aging society, the geriatric patient population is steadily increasing. These patients often suffer from comorbidities and require numerous oral medications, which can be especially challenging for dysphagic geriatric patients. Mucoadhesive buccal…
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Roquette presents a new product: KLEPTOSE® F 7% - EXP β-cyclodextrin for oral dosage forms contains less than 7% of water. It is well suited for dry processing techniques, such as direct compression, where its low water content benefits moisture-sensitive APIs and formulations (e.g., ODTs,…
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This study evaluates the in vivo mucoadhesive properties of thiolated cyclodextrins (CDs) with varying S-protection using polyethylene glycol (PEG) of different chain lengths. Free thiol groups of thiolated β-CDs (CD-SH) were S-protected with 1 kDa and 2 kDa PEG bearing a terminal thiol group,…
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ABSTRACT: Piroxicam is an oxicam class of NSAID which is a drug of choice in the treatment of severe pains occurs in chronic diseases like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and many more severe conditions. The solid dispersion method with piroxicam were prepared by…
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Abstract This study explores the potential of spectroscopic analysis combined with Partial Least Squares Regression (PLS) and Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) for the simultaneous quantification of antibiotics in multicomponent drug formulations, specifically…
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Abstract Pharmaceutical excipients such as P-glycoprotein inhibitors can also increase the solubility and affinity of drugs to the intestinal membrane, enhance paracellular pathways and endocyte uptake, and activate lymph transport pathways, thereby increasing the bioavailability of oral drugs.…
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