Cyclodextrin

Abstract The work involved taste masking of primaquine phosphate (PMQ), an intensely bitter drug used in the prevention and treatment of relapses of malarial infections caused by Plasmodium vivax and ovale. Drug and cation exchange resins viz, AmberLite™ IRP 64, 69, and 88 (IER 64, IER69, and…
Read More...

Abstract Purpose Azelaic acid (AZE) is a widely used agent in acne treatment, but its poor water solubility limits its therapeutic potential. In this study, the effectiveness of azelaic acid (AZE)—a compound with limited therapeutic efficacy due to its poor water solubility—was investigated in…
Read More...

Abstract This research study aimed to develop and evaluate a novel freeze-dried nanocrystals formulation of sotorasib (AMG-510) using Quality by Design (QbD) approach to enhance solubility, dissolution, and oral bioavailability. A QbD framework use for identification, optimization and validation of…
Read More...

Abstract The present study deals with development and characterization of quercetin (QCT) – loaded sulfobutylether-β-cyclodextrin (SBE-β-CD) inclusion complex (IC) incorporated into eudragit S100 (ES100) nanofibers (NF) for colon specific delivery. The 1H – NMR and 2D – NOESY experiments revealed…
Read More...

Abstract Cyclodextrins (CDs) are cyclic oligosaccharides primarily used as excipients in the formulation of drugs, including those intended for pulmonary delivery. CDs have gained increased attention for their use as drug solubilizers. The beneficial role they play in the formulation of drugs…
Read More...

Abstract Introduction Fast-disintegrating electrospun fibers are emerging as innovative systems for oral drug delivery. These fibers possess a high surface area, porosity, and customizable hydrophilicity, which facilitates quick drug release by disintegrating rapidly in biological fluids or upon…
Read More...

Abstract Most novel active pharmaceutical ingredients have low water solubility; therefore, solubility-enhancing methods are applied. The aim of the present investigation is to study the impact of nine commonly used pharmaceutical excipients (fillers, surfactants, cyclodextrins, polymers) on…
Read More...

Abstract Diabetes mellitus (DM) poses a significant global health challenge, with escalating prevalence rates and associated complications necessitating urgent attention. Traditional insulin delivery methods, such as multiple daily subcutaneous injections, present challenges in terms of patient…
Read More...

Abstract Multiple sclerosis is a chronic neuroimmunological disorder that causes progressive disability, primarily in young adults. It places a significant burden on healthcare systems due to high medication costs and long-term care needs. Implantable devices offer a promising alternative for…
Read More...

Abstract Background: Rheumatoid arthritis is a chronic autoimmune disease that leads to severe disability and requires improved therapeutic strategies to optimize anti-inflammatory treatment. This study aimed to address this challenge by developing and characterizing an extended-release polymer…
Read More...