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Cyclodextrin
KLEPTOSE® BioPharma Hydroxypropyl Beta-Cyclodextrin as a Potential Functional Alternative to…
Roquette presented a new case study lately. See the use of KLEPTOSE® BioPharma Hydroxypropyl Beta-Cyclodextrin as a potential functional alternative to surfactants in the following:
CHALLENGE
Therapeutic proteins are inherently unstable and are sensitive to temperature change, shearing, shaking,…
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Enhancing solubility and stability of piperine using β-cyclodextrin derivatives: computational and…
Piperine (PP), a natural alkaloid found in black pepper, possesses significant bioactivities. However, its use in pharmaceutical applications is hindered by low water solubility and susceptibility to UV light degradation. To overcome these challenges, we investigated the potential of β-cyclodextrin…
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Nose-to Brain Delivery of Resveratrol, a Non-Invasive Method for the Treatment of Cerebral Ischemia
Abstract
Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, high associated mortality, and the permanent disability in patients that survive it. Numerous studies in animal models have demonstrated the protective properties of resveratrol…
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Mechanistic Insight in Permeability through Different Membranes in the Presence of Pharmaceutical…
The present study reports the effects of two pharmaceutical excipients of differing natures—non-ionic surfactant pluronic F127 (F127) and anionic sulfobutylether-β-cyclodextrin (SBE-β-CD)—on the permeation of the model compound, carbamazepine (CBZ). The permeability coefficients of CBZ at three…
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Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate
Despite major improvements brought about by the introduction of taste-masked formulations of 4-phenylbutyrate (PB), poor compliance remains a significant drawback to treatment for some pediatric and dysphagic patients with urea cycle disorders (UCDs). This study reports on the development of a…
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Febuxostat ternary inclusion complex using SBE7-βCD in presence of a water-soluble polymer:…
Febuxostat (FBX), a potent xanthine oxidase inhibitor, is widely used as a blood uric acid-reducing agent and has recently shown a promising repurposing outcome as an anti-cancer. FBX is known for its poor water solubility, which is the main cause of its weak oral bioavailability. In a previous…
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Investigating the prilling/vibration technique to produce gastric-directed drug delivery systems for…
Prilling/vibration technique to produce oral microcapsules was explored to achieve local delivery of misoprostol (MIS), a prostaglandin E1 analogue indicated for the treatment of gastric-duodenal ulcers, at the gastric mucosa. To improve MIS chemical stability and reduce its associated systemic side…
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Development of nanoparticles based on amphiphilic cyclodextrins for the delivery of active…
Abstract
Amphiphilic cyclodextrin derivatives (ACD) are useful starting materials for nanomedicines; however, their synthesis using enzymatic catalysis is unsatisfactory. This work focuses on a robust alternative pathway using mineral base catalysis to transesterify β-cyclodextrin with long-chain…
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Single and Multitarget Systems for Drug Delivery and Detection: Up-to-Date Strategies for Brain…
Abstract
This review summarizes the recent findings on the development of different types of single and multitarget nanoparticles for disease detection and drug delivery to the brain, focusing on promising active principles encapsulated and nanoparticle surface modification and functionalization.…
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Low melting mixtures: Neoteric green solvents for flavor formulation
Abstract
Flavors are considered among the most valuable ingredients in any formula. However, aromatic substances are volatile and can be lost during processing and storage. Thus, it is beneficial to develop strategies for their retention in formulations. The aim of the present study was to evaluate…
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