Glatt CPS® Technology: Case study

The Glatt CPS® Technology (Complex Perfect Spheres) is a fluid bed rotor technology for producing spherical matrix pellets with a smooth surface and high density. Typically, microcrystalline cellulose is used as a basic excipient for pelletization using the CPS® Technology. In the past extensive studies using soluble APIs (active pharmaceutical ingredient) as Metoprolol succinate and Propranolol hydrochloride were performed. During this study matrix pellets containing an insoluble API shall be developed whereby a high drug load was envisaged (not less than 50 %). Furthermore, the particles shall be as spherical as possible, and the D90 value of the particle size distribution should not exceed 400 µm.
Download case study here: The path to a perfect sphere

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