excipients

Premium ethylcellulose polymers are hydrophobic cellulose ether based biomaterials widely employed as biocompatible templates for the design of novel drug delivery systems. They are classified as United States Food and Drug Administration Generally-Recognized-As-Safe chemical substances and have…
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The pharmaceutical industry faces technical challenges in the near future when transitioning from the traditional batch wise manufacturing to continuous manufacturing. One issue that needs to be solved is how to obtain high-quality measurements of a moving solid powder sample. The aim of this…
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The aims of this work were to develop a processable, electrospun formulation of a model biopharmaceutical drug, β-galactosidase, and to demonstrate that higher production rates of biopharmaceutical-containing fibers can be achieved by using high-speed electrospinning compared to traditional…
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Currently, sixty-five original sprinkle drug products are available in various dosage forms including tablets, powders, granules, immediate-release capsules, extended-release capsules, delayed-release capsules, and multiparticulate drug delivery systems. By sprinkling on soft food vehicles, these…
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Continuous manufacturing is an emerging technology in secondary pharmaceutical manufacturing of oral solid dosage forms such as tablets. Continuous blending is a crucial process step in continuous manufacturing. Residence mass (i.e. fill level or hold-up mass) is a critical process parameter of…
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The application of process analytical technologies (PAT) to monitor critical quality attributes (CQAs) provides an important approach to enhance process understanding and improve the reliability of pharmaceutical production processes. The present study focuses on the first PAT based feedback…
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Pharmaceutical excipients in drug products are defined as pharmacologically inactive and are integral constituents of all types of oral dosage forms. However, some excipients may increase drug absorption by interacting with the mucosal membrane. If the strategy is to use an excipient with a…
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Film coating of pharmaceutical dosage forms, such as tablets and pellets, can be used to tailor the drug release profile. With that regard, a uniform coating thickness of a single tablet (intra-tablet), all tablets (inter-tablet) and subsequent batches (inter-batch) is crucial. We present a…
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WILMINGTON, Del., July 9, 2019 /PRNewswire/ -- Noramco and SPI Pharma announced that they have completed work on an excipient compatibility study examining a range of options for the development of cannabidiol (CBD) solid oral dosage forms, including orally-disintegrating tablets (ODT),…
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Chitosan has not been able to be formulated as sustained-release crosslinked/coacervated drug carrier in the form of spheroids prepared by extrusion-spheronisation technique. This study re-visits chitosan spheroids and their drug (water-soluble chlorpheniramine maleate) release profiles as a…
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