Drug Delivery

Abstract Block copolymer micelles, formed by the self-assembly of amphiphilic polymers, address formulation challenges, such as poor drug solubility and permeability. These micelles offer advantages including a smaller size, easier preparation, sterilization, and superior solubilization, compared…
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Softgel capsules are a popular choice for delivering a wide range of compounds, from pharmaceuticals to nutritional supplements. Their versatility and efficacy hinge on the type of fill material used. Let's explore the three primary types of fills for softgel capsules: Single Oil or Oil Mixtures,…
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Abstract Self-emulsifying drug delivery systems (SEDDSs) represent a significant breakthrough in addressing bioavailability challenges by enhancing the solubilization of poorly water-soluble drugs, ensuring consistent formulation properties, and facilitating easy industrial scale-up. Despite…
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Local drug delivery to the esophagus is hampered by rapid transit time and poor permeability of the mucosa. If some strategies aimed to improve the residence time have been proposed, non-invasive approaches to increase the drug penetration in the mucosa have not been described so far. Herein, we…
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Abstract The disadvantages of some conventional drugs, including their low bioavailability, poor targeting efficiency, and important side effects, have led to the rational design of drug delivery systems. In particular, the introduction of drug delivery systems is a potential approach to enhance…
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Soft Gelatin Capsules (SGCs), commonly known as softgels, have transformed drug delivery since their invention. Despite their 19th-century origins, their widespread adoption only began in the 20th century, thanks to technological advancements by Robert Pauli Scherer. This innovation revolutionized…
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Drug repositioning is a high-priority and feasible strategy in the field of oncology research, where the unmet medical needs are continuously unbalanced. Disulfiram is a potential non-chemotherapeutic, adjuvant anticancer agent. However, the clinical translation is limited by the drug‘s poor…
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Schizophrenia is a psychiatric disorder that results from abnormal levels of neurotransmitters in the brain. Risperidone (RIS) is a common drug prescribed for the treatment of schizophrenia. RIS is a hydrophobic drug that is typically administered orally or intramuscularly. Transdermal drug delivery…
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INTRODUCTION CANDESARTAN CILEXETIL (CDC) An angiotensin II receptor antagonist is a prodrug which gets converted to active drug Candersartan during absorption from the gastrointestinal tract. The conventional CDC tablets have a significantly low bioavailability of approximately 14% after oral…
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ABSTRACT Background Novel delivery strategies are being explored since low bioavailability presents a challenge for medications like valsartan. Mucoadhesive drug delivery systems present a viable alternative by enhancing drug absorption and retention. Aim This study aimed to develop…
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