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Drug Delivery
Hydrogels in Drug Delivery – Part 1
Hydrogels in Drug Delivery
See the new book, edited by Alejandro J. Paredes, Garry Laverty, Eneko Larrañeta, Ryan F. Donnelly. It covers the fundamental mechanisms of drug delivery from a hydrophilic matrix, breaks down interconnections between introductory theory and applied materials chapters and…
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Development and optimization of lyophilized dry emulsion tablet for improved oral delivery of…
Abstract
Ivermectin (IVM) is a widely used antiparasitic agent and has been repurposed for the treatment of COVID-19. However, its poor water solubility and low bioavailability present significant challenges, often requiring large doses for therapeutic effectiveness. This poses a burden on…
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Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Abstract
Intraoral delivery of active pharmaceutical ingredients (API) is an attractive approach to improve their local therapeutic efficacy or to enable their systemic delivery. It offers several advantages, such as high drug concentration at the intraoral target site and rapid access to the…
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Foam-Based Drug Delivery Systems for Skin Disorders: A Comprehensive Review
Abstract
Foam-based drug delivery systems signify a significant innovation in dermatology, facilitating improved drug penetration and administration via a gas-liquid dispersion matrix. These formulations have shown considerable promise in the medical, cosmetic, and pharmaceutical fields. Recent…
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A recent update of water-soluble polymers in cyclodextrin-based formulations for mucosal drug…
Abstract
Cyclodextrins (CDs) play a crucial role in pharmaceutical formulations due to their unique ability to form inclusion complexes with a wide range of lipophilic drugs. Ternary complexes comprising CD, water-soluble polymer, and drug molecule have emerged as promising multicomponent to the…
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The Future of Oral Biologics: Solid Sedds Powered by NEUSILIN® UFL2
Introduction
Self-emulsifying drug delivery systems (SEDDS) have emerged as a promising approach for enhancing the oral bioavailability of challenging therapeutic compounds, particularly biopharmaceuticals like proteins and peptides.
A study published in “Pharmaceutics” journal showcases an…
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Trans-Resveratrol-Loaded Nanostructured Lipid Carrier Formulations for Pulmonary Drug Delivery Using…
Abstract
Aerosolization is a non-invasive approach of delivering drugs for both localized and systemic effects, specifically pulmonary targeting. The aim of this study was to deliver trans-resveratrol (TR) as an anti-cancer drug entrapped in a new generation versatile carriers nanostructured lipid…
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Investigation of bioavailability and anti-pancreatic cancer efficacy of a self-nanoemulsifying…
Abstract
Aims
A new self-nanoemulsifying drug delivery system (SNEDDS) was developed for erlotinib (Ert) oral delivery.
Highlights
A pseudo-ternary phase diagram for olive oil, Tween 80 and PEG 600 was constructed.
A SNEDDS composed of 10% olive oil, 20% Tween 80 and 70% (V)…
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Acyl chitosan based self-nanoemulsifying drug delivery system of lipophilic drug with enhanced oral…
Abstract
This study developed a mucoadhesive self-nano emulsifying drug delivery system (SNEDDS) with synthesized acyl chitosan coating for enhancing oral bioavailability and drug retention of Amphotericin B (AB) which is conventionally administered parenterally owing to its poor bioavailability.…
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PLGA-Based Strategies for Intranasal and Pulmonary Applications
Abstract
Poly(D,L-lactide-co-glycolide) (PLGA) has emerged as a cornerstone in the development of advanced drug delivery systems, particularly for intranasal and pulmonary routes. Its biodegradability, biocompatibility, and adaptability make it an ideal platform for addressing challenges associated…
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