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News on Pharma Excipients

Development of indomethacin amorphous solid dispersion by applying acid-base supersolubilization
BASF

Development of indomethacin amorphous solid dispersion by applying acid-base supersolubilization (ABS) principle to enhance solubility and enable low-temperature hot melt extrusion

8. January 2026

This study explores a novel acid-base supersolubilization (ABS) principle for enhancing the solubility and dissolution rate of indomethacin, a poorly water-soluble and weakly acidic drug, by interaction with the weak base tromethamine. The reported aqueous solubilities of indomethacin are 1.5...

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