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Rationalizing nose-to-brain drug delivery - Machine learning-guided optimization and mechanistic elucidation of olfactory deposition for nasal sprays
Lactose

Rationalizing nose-to-brain drug delivery: Machine learning-guided optimization and mechanistic elucidation of olfactory deposition for nasal sprays

9. February 2026

Abstract Nose-to-brain drug delivery via nasal sprays is severely limited by low olfactory deposition. In this study, we integrate machine learning with high-throughput experimentation to systematically optimize olfactory deposition of solid lipid nanoparticle-loaded nasal sprays (SLN-NS). By engineering the dispersed...

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