Granulation

Abstract The liquid-to-solid (L/S) ratio is a key process parameter in wet granulation processes, which ensures that the final granules meet the desired quality attributes. Mixer torque rheometer (MTR) is an established instrument to determine this parameter by measuring torque changes as a…
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Abstract Methods: Effervescent granules containing citric acid and sodium bicarbonate were successfully prepared for the first time via TS-MG using a polyol (sorbitol) as a melt binder. Results: Processing parameters, specifically granulation temperature and screw speed, were systematically…
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Patients and caregivers experience challenges following a prescribed medicine routine. If the active pharmaceutical ingredients (API) are released quickly then patients may require multiple doses of the drug. That is to maintain treatment effectiveness. Uneven treatment and adverse effects can arise…
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Abstract We study the response of two twin-screw granulators of different barrel diameter to the variation of three process parameters (liquid-to-solid ratio, screw speed and throughput), while maintaining the same shear rate field along the screws. Various responses, including size distribution,…
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Abstract Roller compaction/dry granulation (RC/DG) is a key process in pharmaceutical manufacturing for improving powder flowability, density, and segregation resistance. Advanced statistical modeling was used to optimize RD/DG process parameters and subsequently binder compositions by employing…
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This poster was presented at the ECP 2025 in Porto Introduction Tablets are one of the most widely used oral dosage forms for oral delivery in the pharmaceutical and nutraceutical industries. If the drug dose per tablet is high and the formulation cannot ensure direct compression…
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This poster was presented at the ECP 2025 in Porto Introduction Polyols, such as mannitol, sorbitol, and isomalt, are widely used as excipients for tablet direct compression formulations because of their excellent compaction properties, flowability, as well as high and pH independent…
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This poster was presented at the ECP 2025 in Porto Introduction The agglomeration of fine powders during the twin-screw melt granulation (TSMG) occurs due to the softening or melting of thermal binders, consolidation by kneading (applied mechanical forces) and cooling to room temperature along…
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The effect of binder types on the granule properties and tablet quality for high shear wet granulation and tableting (HSWG-T) was studied. Furthermore, attribute correlation was established by multivariate models based on a systematical study of the binder’s properties, wetting mass’s physical…
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GANGWAL Healthcare Pvt. Ltd., part of the prestigious Gangwal Group, has been a pioneer in the Pharmaceutical industry since 1987. Driven by the sense of social wellbeing and the steely determination to make a difference through technology and expertise, Gangwal Healthcare continues to be at the…
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