Granulation

Twin-screw wet granulation (TSG) is a continuous manufacturing technique either for granules as final dosage form or as an intermediate before tableting or capsule filling. A comprehensive process understanding is required to implement TSG, considering various parameters influencing granule and…
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Abstract Roller compaction is a widely used continuous dry granulation process in the food and pharmaceutical industries. The flow and distribution of the powder across the rollers in the compaction area plays a crucial role in determining the quality of the final product. Non-uniform powder flow…
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Abstract Considering the strong dependence of agglomerate characteristics on various operating parameters, this study employs the control variable methodology (CVM) and response surface methodology (RSM) to investigate the influence of multi-factor interactions on particle growth during top-spray…
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ABSTRACT Introduction: The pharmaceutical industry is gradually changing batch-wise manufacturing processes to continuous manufacturing processes, due to the advantages it has to offer. The final product quality and process efficiency of continuous manufacturing processes is among others impacted…
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We invite you to our next webinar: "Controlled Release for Nutraceuticals" During this webinar we will cover the key topics related to controlled release for nutraceuticals. We will address: New trends in enteric coating excipients by Marek Lachmann from BIOGRUND…
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Purpose Continuous manufacturing (CM) gains more and more interest in the pharmaceutical industry, which is guided by the FDA in Pharma 4.0. With CM gaining ever so importance, understanding of physical properties of powders to predict behavior in different process units is crucial. Raw…
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Tablet disintegration is crucial for drug release and subsequent systemic absorption. Although factors affecting the disintegrant’s functionality have been extensively studied, the impact of wet granulation on the performance of disintegrants in a poorly water-soluble matrix has received much less…
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Real-time monitoring of critical quality attributes, such as residual water in granules after drying which can be determined through loss-on-drying (LOD), during wet granulation and drying is essential in continuous manufacturing. Near-infrared (NIR) spectroscopy has been widely used as process…
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Abstract The preparation of pellets using a high-shear granulator in a rapid single-step is considered a good economic alternative to the extrusion spheronization process. As process parameters and material attributes greatly affect pellet qualities, successful process optimization plays a vital…
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Binder selection is a crucial step in continuous twin-screw wet granulation (TSWG), as the material experiences a much shorter residence time (2–40 s) in the granulator barrel compared to batch-wise granulation processes. Polyvinyl alcohol (PVA) 4-88 was identified as an effective binder during…
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