HPMCAS - Hydroxypropyl methylcellulose acetate succinate

Abstract Hydroxypropyl methylcellulose acetate succinate (HPMCAS) is commonly used to develop amorphous solid dispersions (ASDs), but its use is mostly...

Abstract Amorphous solid dispersions (ASDs) remain a key strategy for enhancing the dissolution of poorly soluble APIs. Building on previous...

Abstract Delamanid, an antituberculosis drug used for multidrug-resistant tuberculosis, has extremely poor water solubility and a high melting point of...

Abstract Supersaturation is a widely employed strategy to improve the oral bioavailability of poorly soluble drugs, but its application is...

Abstract Here, we report dissolution of aprepitant from three phospholipid-based amorphous solid dispersions (ASDs), namely binary ASDs containing drug and...

Abstract Poor tablet hardness and drug re-crystallization are two common challenges of amorphous solid dispersion (ASD) formulations prepared with hot-melt...

Abstract In recent years, the environmental assessment and optimization of pharmaceutical dosage forms have received increasing attention. Consequently, interest in...

Abstract Background: Three-dimensional (3D) printing has been established in pharmaceutical sciences for preparing customized dosage forms with intricate release profiles....

Abstract Poor aqueous solubility and thereby poor and/or variable bioavailability of drug candidates is frequently overcome by developing enabling formulations...

Abstract The limited aqueous solubility of numerous active pharmaceutical ingredients (APIs) remains a major barrier to achieving optimal oral bioavailability,...