HPMCAS - Hydroxypropyl methylcellulose acetate succinate

Abstract Spray dried dispersion (SDD) is increasingly used in solid dose formulations for poorly soluble active pharmaceutical ingredients (APIs). Dissolution...

Abstract Hydroxypropyl methylcellulose acetate succinate (HPMCAS) is commonly used to develop amorphous solid dispersions (ASDs), but its use is mostly...

Abstract Amorphous solid dispersions (ASDs) remain a key strategy for enhancing the dissolution of poorly soluble APIs. Building on previous...

Abstract Delamanid, an antituberculosis drug used for multidrug-resistant tuberculosis, has extremely poor water solubility and a high melting point of...

Abstract Supersaturation is a widely employed strategy to improve the oral bioavailability of poorly soluble drugs, but its application is...

Abstract Here, we report dissolution of aprepitant from three phospholipid-based amorphous solid dispersions (ASDs), namely binary ASDs containing drug and...

Abstract Poor tablet hardness and drug re-crystallization are two common challenges of amorphous solid dispersion (ASD) formulations prepared with hot-melt...

Abstract In recent years, the environmental assessment and optimization of pharmaceutical dosage forms have received increasing attention. Consequently, interest in...

Abstract Background: Three-dimensional (3D) printing has been established in pharmaceutical sciences for preparing customized dosage forms with intricate release profiles....

Abstract Poor aqueous solubility and thereby poor and/or variable bioavailability of drug candidates is frequently overcome by developing enabling formulations...