Hydroxypropyl methylcellulose acetate succinate (HPMCAS)

Hot melt extrudates with combinations of Soluplus® and Aqoat® AS-L or Eudragit® EPO were investigated to improve drug release and to overcome the pH-dependent release of poorly water-soluble basic (itraconazole, ITZ) and acidic (mefenamic acid, MFA) drugs. The release of ITZ was improved in both 0.1…
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Abstract In this study, once-daily extended-release tablets with dual-phase release of oseltamivir phosphate were developed for the treatment of influenza. The goal was to improve patient adherence and offer more therapeutic choices. The tablets were manufactured using wet granulation, bilayer…
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Pretomanid (PTM), an oral antibiotic used in the treatment of adults with pulmonary extensively drug-resistant, nonresponsive multidrug-resistant tuberculosis (MDR-TB). It is a poor glass former, that shows high recrystallization tendency from the amorphous and supersaturated state, resulting in low…
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This poster was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical  (PBP) Technology, 18 - 21 March 2024, Vienna, Austria: INTRODUCTION Hot melt extrusion (HME) has become increasingly popular in pharmaceutical manufacturing over the last decade1. This…
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Production of amorphous solid dispersions (ASDs) is an invaluable technique to promote the solubility and bioavailability of medicinal substances. ASD is manufactured using a variety of classic and modern techniques, most of which rely on either melting or solvent evaporation. This proof-of-concept…
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Shin-Etsu supplies the various excipients for pharmaceutical industry. Let us introduce you Shin-Etsu AQOAT® Hypromellose acetate succinate (HPMCAS, NF, JP), an enteric coating material that can be used in aqueous or organic media. Hypromellose is a non-toxic material which has been used in…
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Abstract Background. Amoxicillin trihydrate possesses poor solubility, compressibility, and flow behavior. Amorphous solid dispersion prepared by spray drying could solve all three problems at the same time. Objective. To prepare amorphous solid dispersion after screening of polymers by solvent…
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Poorly water-soluble drugs present a significant challenge in the development of oral solid dosage forms (OSDs). In formulation development the appropriate use of excipients to adjust solubility, and the choice of manufacturing method and pharmaceutical processes to obtain a dosage form to meet the…
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This study aims to investigate the potential use of polymer inclusion in the phospholipid-based solid dispersion approach for augmenting the biopharmaceutical performance of Aprepitant (APT). Initially, different polymers were screened using the microarray plate method to assess their ability to…
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Implants are drug delivery platforms that consist of a drug-polymer matrix with the ability of providing a localized and efficient controlled release of the drug with minimal side effects and achievement of the desired therapeutic outcomes with low drug loadings. Direct powder extrusion (DPE) 3D…
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