Inorganic Chemicals

The material library is an emerging, new data-driven approach for developing pharmaceutical process models. How many materials or samples should be involved in a particular application scenario is unclear, and the impact of sample size on process modeling is worth discussing. In this work, the…
Read More...

The pharmaceutical industry is paying more and more attention to hot-melt extrusion (HME), but this technology's promise for creating solid self-emulsifying drug delivery systems (S-SMEDDS) has not yet been fully realized. The numerous published publications over the past five years show that hot…
Read More...

Abstract Continuous manufacturing is a novel concept to produce high quality drug products. The manufacture of solid dosage forms starts with the feeding of materials, which is consider a critical step because it could have a high influence on the quality of the final product. Therefore, this unit…
Read More...

Porous hydroxyapatite (HAP) pellets were prepared by extrusion/spheronization/sintering and loaded with Lactobacillus (La-5). Micronized (PFm) or coarse size (PFc) microcrystalline cellulose were the pore formers, while HAP grades from Budenheim (Tri-cafos®) and Sigma-Aldrich with different specific…
Read More...

The continued popularity into the 21st century of extended release matrices based on hydroxypropyl methylcellulose (HPMC) can be attributed to (i) the effectiveness of hydrophilic matrix technology, (ii) the high acceptability of the polymer, (iii) the ease of dosage form manufacture and (iv) a…
Read More...

Abstract Pharmaceutical tablet formulations combine the active ingredient with processing aids and functional components. This paper evaluates compressibility based predictive models for binary and ternary formulations to establish an acceptable range of tablet compression parameters that satisfy…
Read More...

Abstract Drug loading into mesoporous carriers may help to improve the dissolution of poorly aqueous-soluble drugs. However, both preparation method and carrier properties influence loading efficiency and drug release. Accordingly, this study aimed to compare two preparation methods: formulation…
Read More...

Abstract Twin-screw wet granulation is an emerging continuous manufacturing technology for solid oral dosage forms. This technology has been successfully employed for the commercial manufacture of immediate-released tablets. However, the higher polymer content in extended-release (ER) formulations…
Read More...

Oral dispersible tablets (ODTs) are patient compliant dosage forms which rapidly disintegrate in the mouth following active absorption with rapid onset of action. The current study was designed to resolve compression problems used for ODTs, as high compression force exhibited hardness and drug…
Read More...

ABSTRACT A novel drug delivery system plays a pivotal role in enhancing patient adherence to medication regimens. Among these innovative approaches, fast dissolving tablets (FDT’s) stand out as a particularly promising option. FDT’s offer a range of benefits, including precise dosing, ease of…
Read More...