Calcium Phosphates

Porous hydroxyapatite (HAP) pellets were prepared by extrusion/spheronization/sintering and loaded with Lactobacillus (La-5). Micronized (PFm) or coarse size (PFc) microcrystalline cellulose were the pore formers, while HAP grades from Budenheim (Tri-cafos®) and Sigma-Aldrich with different specific…
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The continued popularity into the 21st century of extended release matrices based on hydroxypropyl methylcellulose (HPMC) can be attributed to (i) the effectiveness of hydrophilic matrix technology, (ii) the high acceptability of the polymer, (iii) the ease of dosage form manufacture and (iv) a…
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Abstract Pharmaceutical tablet formulations combine the active ingredient with processing aids and functional components. This paper evaluates compressibility based predictive models for binary and ternary formulations to establish an acceptable range of tablet compression parameters that satisfy…
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Abstract Twin-screw wet granulation is an emerging continuous manufacturing technology for solid oral dosage forms. This technology has been successfully employed for the commercial manufacture of immediate-released tablets. However, the higher polymer content in extended-release (ER) formulations…
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Oral dispersible tablets (ODTs) are patient compliant dosage forms which rapidly disintegrate in the mouth following active absorption with rapid onset of action. The current study was designed to resolve compression problems used for ODTs, as high compression force exhibited hardness and drug…
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The successful integration of hot-melt extrusion (HME) and fused deposition modelling (FDM) depends on a better understanding of the impact of environmental conditions on the printability of formulations, since they significantly affect the properties of the raw materials, whose control is crucial…
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Abstract Freeze-drying of biopharmaceutical products is the method of choice in order to improve their stability and storage conditions. Such Freeze-dried products are usually intended for parenteral route administration. However, many biopharmaceutical materials administered by parenteral route…
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Abstract This work presents a system, where deep learning was used on images captured with a digital camera to simultaneously determine the API concentration and the particle size distribution (PSD) of two components of a powder blend. The blend consisted of acetylsalicylic acid (ASA) and calcium…
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Nanotechnology-based-drug-delivery processes are widely applicable for specific drug release. Various pharmaceutical carriers, such as polymeric nano-carriers (solid lipid nanoparticles, micelles, nano-gels/hydrogels, dendrimers, polymeric nano-shapes), vesicular carriers (liposome, noisome),…
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PRESS RELEASE Oftringen (Switzerland), September 2023 – Manufacturers in the field of pharma and nutraceuticals can step into a new era of uncomplicated and future-proof formulation: With the Omyanutra® range, Suisse mineral expert Omya offers advanced excipients to overcome the challenge of…
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