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Lipid nanoparticles
Effect of lipid composition on RNA-Lipid nanoparticle properties and their sensitivity to thin-film…
A library of 16 lipid nanoparticle (LNP) formulations with orthogonally varying lipid molar ratios was designed and synthesized, using polyadenylic acid as a model for mRNA, to explore the effect of lipid composition in LNPs on (i) the initial size of the resultant LNPs and encapsulation efficiency…
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Data-driven development of an oral lipid-based nanoparticle formulation of a hydrophobic drug
Due to its cost-effectiveness, convenience, and high patient adherence, oral drug administration normally remains the preferred approach. Yet, the effective delivery of hydrophobic drugs via the oral route is often hindered by their limited water solubility and first-pass metabolism. To mitigate…
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Nanoemulsions and Solid Lipid Nanoparticles with Encapsulated Doxorubicin and Thymoquinone
Nanoemulsions (NEs) and solid lipid nanoparticles (SLNs) are promising drug delivery systems. In this work, paraffin oil NEs and stearic acid SLNs stabilized with Tween 60 and Span 60 have been studied. NEs with an average droplet diameter of ~50 nm and suspensions of SLNs with an average size of…
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Single and Multitarget Systems for Drug Delivery and Detection: Up-to-Date Strategies for Brain…
Abstract
This review summarizes the recent findings on the development of different types of single and multitarget nanoparticles for disease detection and drug delivery to the brain, focusing on promising active principles encapsulated and nanoparticle surface modification and functionalization.…
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Cancer nanomedicine: emergence, expansion, and expectations
The introduction of cancer nanomedicine has substantially enhanced the effectiveness of cancer treatments. Nano-formulations are becoming more prevalent among other treatment methods due to their improved therapeutic efficacy and low systemic toxicity. The discovery of the enhanced permeability and…
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Quality by Design Galvanized development of resveratrol loaded PLGA nanoparticles: In vitro and Ex…
Melanoma is a lethal form of skin cancer, which progresses with poor prognosis. The melanoma tumors are highly metastatic in nature, which often leads to tumorigenesis in lungs and brain tissues. Invasion and migration are mainly responsible for poor 5-year survival rate of ∼32 % after diagnosis of…
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Nintedanib solid lipid nanoparticles improve oral bioavailability and ameliorate pulmonary fibrosis…
Nintedanib (NIN) and pirfenidone are the only approved drugs for the treatment of Idiopathic Pulmonary Fibrosis (IPF). However, NIN and pirfenidone have low oral bioavailability and limited therapeutic potential, requiring higher dosages to increase their efficacy, which causes significant liver and…
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Development of famotidine-loaded lecithin-chitosan nanoparticles for prolonged and efficient…
Lecithin-chitosan nanoparticles (LCNPs) represent an appealing nanocarrier for the oral delivery of hydrophobic drugs. Negatively charged lecithin and positively charged chitosan were permitted to interact to create LCNPs. Their distinctive features enable drugs to be encapsulated into the…
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Sensitivity analysis of the formation of hollow solid lipid micro- and nanoparticles from…
Abstract
The production of hollow solid micro- and nanoparticles using fully hydrogenated soybean oil (FHSO) and supercritical carbon dioxide (SC-CO2) has been studied in the literature. This research aimed to examine the impact of FHSO volumes (10 to 50 ml), temperatures (60 to 80 °C), and…
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Quality by design (QbD) commended exploration of bosutinib loaded lipid nanocarriers for food effect…
Abstract
Bosutinib (BOS), a BCS class IV drug suffers from poor aqueous solubility and bioavailability along with significant food effect. Lipid nanocarriers (LNC) have the potential to circumvent bioavailability related issues associated with hydrophobic moieties. In this endeavor, we explore the…
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