Lipid Nanoparticles

Messenger RNA (mRNA) is intrinsically unstable due to spontaneous 2'-hydroxyl-mediated phosphodiester hydrolysis, with degradation rates accelerating at pH below 5.0...

Abstract Entacapone is a catechol-O-methyltransferase (COMT) inhibitor, widely used for the symptomatic treatment of Parkinson’s disease. However, it presents setbacks...

Abstract The taste of a drug formulation, especially of orodispersible and liquid dosage forms, is of crucial importance due to...

Abstract Purpose Conventional chemotherapy is limited by premature drug leakage, systemic toxicity, and inefficient intracellular co-delivery, leading to reduced therapeutic...

Abstract The anti-glaucoma drug betaxolol hydrochloride (BH) exhibits poor ocular bioavailability due to limited corneal permeability, rapid precorneal loss, short...

Abstract Tolcapone is a nitrocatechol-based drug used as adjuvant therapy in Parkinson’s Disease (PD). Despite being effective in managing PD-associated...

Abstract Building on growing evidence that ionizable lipids improve RNA delivery, in this work, we developed ionizable lipid/poly(lactic-co-glycolic acid) hybrid...

Abstract Macrophages, as cells of the innate immune response, are involved in the pathology of various medical conditions (tumors, intracellular...

Abstract The development of polymeric biomaterials for modern pharmaceutical formulations has attracted considerable attention, given the recent trend of advanced...

Abstract Contemporary small-molecule drug candidates increasingly have limited aqueous solubility, rendering oral delivery challenging. Amorphous solid dispersions (ASDs) and lipid-based...