Lipid Nanoparticles

The large-scale global application of messenger ribonucleic acid–lipid nanoparticles (mRNA-LNPs) is severely restricted by their mandatory ultra-low-temperature storage requirement, which...

Abstract Lipid nanoparticles (LNPs) administered parenterally often show poor localization to multiple tissue types, including the pancreas and gastrointestinal (GI)...

Abstract Purpose Rheumatoid arthritis is a chronic autoimmune disease requiring long-term therapy, often limited by systemic adverse effects and inadequate...

Abstract Drug-excipient interaction studies are fundamental for the efficient development of new formulations. These interactions directly influence drug stability, loading...

Abstract Spray-freeze drying (SFD) is a promising drying technique for stabilizing RNA lipid nanoparticles (RNA-LNPs) by converting them into solid-state...

Abstract Backgorund/Objectives: Respiratory diseases represent a substantial global health burden and require effective localised pulmonary delivery strategies, particularly for poorly water-soluble...

Abstract Glioblastoma is one of the aggressive and hard-to-treat forms of brain tumor, and this is largely due to the...

Abstract Background: Lipid nanoparticles are widely investigated as oral drug delivery systems, but their intestinal performance remains difficult to predict based...

Abstract This study optimized the formulation parameters of nanostructured lipid carriers (NLCs) loaded with Origanum vulgare L. essential oil (OEO), produced by...

Abstract Inhalable messenger RNA (mRNA) therapeutics provide direct access to the respiratory tract but liquid mRNA-lipid nanoparticle (LNP) formulations often...