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Lipid nanoparticles
Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies
In recent years, nanocarriers have played an ever-increasing role in clinical and biomedical applications owing to their unique physicochemical properties and surface functionalities. Lately, much effort has been directed towards the development of smart, stimuli-responsive nanocarriers that are…
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Magnetic Lipid-Based hybrid nanosystems: A combined stimuli- responsive nanocarriers for enriched…
Magnetic Lipid-Based Hybrid Nanosystems (M-LCNPs) is a novel nanoplatform that can respond to magnetic stimulus and are designed for delivering L-carnosine (CN), a challenging dipeptide employed in the treatment of breast cancer. CN exhibits considerable water solubility and undergoes in-vivo…
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Lipid-coated nanocrystals of paclitaxel as dry powder for inhalation: Characterization, in-vitro…
Abstract
Background
Nanocrystals can be produced as a dry powder for inhalation (DPIs) to deliver high doses of drug to the lungs, owing to their high payload and stability to the shear stress of aerosolization force. Furthermore, lipid-coated nanocrystals can be formulated to improve the drug…
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Development and evaluation of hyaluronic acid conjugated tacrolimus-loaded nanostructured lipid…
The proposed research work aims to develop hyaluronic acid conjugated tacrolimus-loaded nanostructured lipid carriers (HYA-TAC-loaded-SA-NLCs) to improve the release rate and cellular uptake to enhance its oral absorption. TAC-loaded-SA-NLCs were prepared using stearylamine as solid lipid and …
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Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of…
Solid lipid microparticles (SLMs) represent a promising approach for drug delivery in anti-acne applications. In this study, asiatic acid-loaded SLMs (AASLMs) were prepared by melt emulsification method in conjunction with freeze-drying. Comprehensive evaluations comprised particle size, %entrapment…
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Overcoming the Low-Stability Bottleneck in the Clinical Translation of Liposomal Pressurized…
Abstract
Currently, several types of inhalable liposomes have been developed. Among them, liposomal pressurized metered-dose inhalers (pMDIs) have gained much attention due to their cost-effectiveness, patient compliance, and accurate dosages. However, the clinical application of liposomal pMDIs…
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Formulation development of methotrexate lipid-based nanogel for treatment of skin cancer
Skin cancer (SC) represents a prevalent malignancy worldwide, characterized by its high drug resistance and limited therapeutic efficacy with conventional treatments. Nanoparticles have emerged as promising vehicles for targeted drug delivery, aiming to overcome these challenges and enhance…
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Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for…
The targeting and mucoadhesive features of chitosan (CS)-linked solid lipid nanoparticles (SLNs) were exploited to efficiently deliver fexofenadine (FEX) into the colon, forming a novel and potential oral therapeutic option for ulcerative colitis (UC) treatment. Different FEX-CS-SLNs with varied…
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Chitosan coated lipid carriers as nanoplatform for repurposed anti-breast cancer activity of…
Drug repurposing is promising strategy with niclosamide showing encouraging results against breast cancer. However, niclosamide hydrophobicity limits its oral bioavailability and minimizes its anti-cancer activity. Nano-structured lipid carriers (NLCs) showed enhance therapeutic performance coping…
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Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery…
Abstract
Studies on bionanocomposite drug carriers are a key area in the field of active substance delivery, introducing innovative approaches to improve drug therapy. Such drug carriers play a crucial role in enhancing the bioavailability of active substances, affecting therapy efficiency and…
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