Browsing Category
Lipids
Development of a new inhaled swellable microsphere system for the dual delivery of naringenin-loaded…
Abstract
This study developed a new dual delivery system of naringenin (NRG), a polyphenol, and doxofylline (DOX), a xanthine derivative, as an inhaled microsphere system. In this system, NRG has been first loaded into glyceryl tristearate-based solid lipid nanoparticles (NRG SLN), which were…
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Breaking barriers: Intranasal delivery of brexpiprazole-nanostructured lipid carriers targets the…
With a peak occurrence in mid-teens to early adulthood, schizophrenia is one of the most debilitating illnesses, distinguished by hallucinations, dementia, psychosis, and delirium. According to figures from the World Health Organization, there are 21 million people who have schizophrenia worldwide,…
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Nanostructured lipid carriers loaded into in situ gels for breast cancer local treatment
In this study, nanostructured lipid carriers (NLC) were developed and employed to obtain in situ thermosensitive formulations for the ductal administration and prolonged retention of drugs as a new strategy for breast cancer local treatment. NLC size was influenced by the type and concentration of…
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Exploring LIPID’s for their Potential to Improves bioavailability of lipophilic drugs candidates: A…
Abstract
This review aims to provide a thorough examination of the benefits, challenges, and advancements in utilizing lipids for more effective drug delivery, ultimately contributing to the development of innovative approaches in pharmaceutical science. Lipophilic drugs, characterized by low…
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Nanostructured Lipid Carriers for Improved Delivery of Therapeutics via the Oral Route
Abstract
Drug delivery via the oral route has always been challenging for poorly soluble drugs. Acid-induced hydrolysis, enzymatic degradation, and poor mucosal absorbency remain the primary hiccups for effective oral delivery of medications. With the advent of nanotechnology, nanostructured lipid…
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Low drug load, high retention mometasone furoate cream with Polyglyceryl – 3 oleate as a…
In the present study, an oil-in-water (O/W) cream containing 0.05% mometasone furoate (MF) was prepared for the treatment of atopic dermatitis (AD) using Polyglyceryl-3 oleate (POCC) as a chemical enhancer. The cream formulation was screened by stability and in vitro skin retention studies and…
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Microemulsions: An Encapsulation Strategy to Increase the Thermal Stability of D-limonene
D-limonene, derived from citrus essential oils, holds significant therapeutic potential but faces challenges due to its high volatility, especially in pharmaceutical formulations. This study investigates microemulsions as a promising delivery system for volatile compounds, emphasizing their thermal…
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Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs
Abstract
The pharmaceutical sector has made considerable strides recently, emphasizing improving drug delivery methods to increase the bioavailability of various drugs. When used as a medication delivery method, nanoemulsions have multiple benefits. Their small droplet size, which is generally…
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Computational Amendment of Parenteral In Situ Forming Particulates’ Characteristics: Design of…
Lipid and/or polymer-based drug conjugates can potentially minimize side effects by increasing drug accumulation at target sites and thus augment patient compliance. Formulation factors can present a potent influence on the characteristics of the obtained systems. The selection of an appropriate…
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Preparation of Nanosized Pharmaceutical Formulations by Dual Centrifugation
Abstract
Dual centrifugation (DC) is an innovative in-vial homogenization and in-vial nanomilling technique that has been in use for the preparation of liposomes for more than one decade. Since then, DC has continuously been developed for preparing various liposomes and other lipid nanoparticles…
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