Lipids

Abstract Amphotericin B (AmB) is used to treat Allergic Bronchopulmonary Aspergillosis (ABPA) caused by Aspergillus fumigatus. AmB is available in oral and injectable forms but has limitations, resulting in low levels of AmB in the lungs. We formulated AmB using Nanostuctured Lipid Carriers (NLCs)…
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Abstract The present study focuses on the development and optimization of a solid self-microemulsifying drug delivery system (SSMEDDS) of Nateglinide, a poorly water-soluble antidiabetic drug, to enhance its oral bioavailability. Initially, a liquid SMEDDS was formulated using Capmul MCM as the…
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Abstract Lipid nanoparticles (LNPs) are of significant interest as delivery systems for various RNA therapeutics, not least due to their outstanding success in applications including the COVID-19 vaccines and the siRNA therapeutic Onpattro®. As LNPs consist of different lipids, the lipid…
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Abstract In this work, liposomes composed of soy phosphatidylcholine (SPC) and cholesterol (CHOL), in addition to sorbitan monolaurate (span 20), a skin penetration enhancer, were incorporated into hydroxyethylcellulose (HEC) hydrogels to optimize the topical administration of 5-fluorouracil (5-FU)…
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Abstract Alzheimer's disease (AD) is a complex neurodegenerative that affects over 55 million people worldwide, a number expected to double by 2050 due to aging populations. This growing prevalence imposes immense societal and economic burdens on healthcare systems and caregivers. AD is challenging…
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Abstract Nowadays, the use of unfractionated low molecular weight heparins through intravenous and subcutaneous routes has been limited by several delivery challenges. These include pharmacological activity fluctuations, bleeding issues, and numerous manufacturing restrictions. To address these …
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Abstract Tendinopathy is a complex musculoskeletal pathology characterized by pain and dysfunction in the tendon. Tendinopathy management includes pharmacological treatments, which, however, have numerous side effects and low efficacy. New pharmacological approaches are essential to overcome these…
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Abstract Solid lipid systems (SLSs) are widely employed to control the release of highly hydrophilic drugs, and they are, in general, obtained by solubilizing or suspending the drug within melted lipid excipients. This work proposes an advantageous strategy to modulate the drug release of a…
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Abstract The purpose of this study was to develop and evaluate a sublingual tablet of lercanidipine hydrochloride for the direct compression method of treating hypertension by using a solid dispersion technique. The dihydropyridine calcium-channel blocker lercanidipine Hydrochloride is used to…
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Abstract Purpose: In our work, we focused on the development of nanostructured lipid carriers (NLCs) loaded with dexibuprofen (DXI) and their application for cancer therapy by proposing the binding of phospholipids with this non-steroidal anti-inflammatory drug (NSAID) to obtain new delivery…
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