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Microneedle
Fundamentals and future trends of 3D printing in drug delivery
Fundamentals and future trends of 3D printing in drug delivery
See the new book, edited by Dimitrios A. Lamprou and Dimitrios G. Fatouros. This book provides an in-depth discussion on key factors affecting the printing process such as different printer technologies, materials selection,…
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Hydrogel-forming microarray patches combined with powder-based reservoir for labetalol hydrochloride…
Abstract
Hypertension is the most common pregnancy disorder and can lead to life-threatening conditions for both mother and fetus. However, managing this condition with oral and intravenous labetalol can be challenging, highlighting the need for alternative delivery methods. This study presents,…
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Transdermal delivery of Acheta domesticus protein hydrolysate using nanostructured lipid carriers…
Abstract
Acheta domesticus protein hydrolysate (PH) is a natural anti-skin aging compound, but its effectiveness is hindered by poor skin penetration due to its hydrophilicity and high molecular weight. This study aimed to compare the enhancement of PH skin delivery by increasing lipophilicity…
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Microneedles loaded with lipid nanocarriers for local treatment of vulvovaginal candidiasis
Abstract
Vaginal yeast infections, such as vulvovaginal candidiasis (VVC), affect nearly three out of four women worldwide. Re-occurrence is frequent and requires repeated treatments with oral, antifungal medications at high doses. Prolonged treatments contribute to development of resistant…
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Evaluation of physical and chemical modifications to drug reservoirs for stimuli-responsive…
Abstract
Hydrogel-forming microneedle (MN) arrays are minimally-invasive devices that can penetrate the stratum corneum, the main barrier to topical drug application, without causing pain. However, drug delivery using hydrogel-forming MN arrays tends to be relatively slow compared to rapid drug…
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Atorvastatin-Loaded Dissolving Microarray Patches for Long-Acting Microdepot Delivery: Comparison of…
Abstract
The increasing popularity of prolonged-release dosage forms, owing to their ability to provide continuous drug release after administration, has significantly improved patient compliance and overall quality of life. However, achieving prolonged release beyond 24 h frequently requires the…
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Enhanced long-acting simvastatin delivery via effervescent powder-carrying hollow microneedles and…
Abstract
Hyperlipidemia and its associated cardiovascular complications are the major causes of mortality and disability worldwide. Simvastatin (SIM) is one of the most commonly prescribed lipid-lowering drugs for the treatment of hyperlipidemia by competitive inhibition of…
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Microneedle patch casting using a micromachined carbon master for enhanced drug delivery
For successful treatment of diseases, sufficient therapeutics must be provided to the body. Microneedle applications in therapeutic delivery and analytics sampling are restricted because of various issues, including smaller area for drug loading and analytics sampling. To achieve sufficient drug…
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Transdermal delivery of bisphosphonates using dissolving and hydrogel-forming microarray patches:…
Abstract
As of 2023, more than 200 million people worldwide are living with osteoporosis. Oral bisphosphonates (BPs) are the primary treatment but can cause gastrointestinal (GI) side effects, reducing patient compliance. Microarray (MAP) technology has the potential to overcome GI irritation by…
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Materials marvels: Pioneering paths in microneedle innovation
Recent developments in materials science have spurred remarkable progress in the field of microneedle technology, offering novel approaches to address key challenges in drug delivery, biosensing, and other biomedical applications. This preview examines three innovative concepts inspired by recent…
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