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Microneedle
Strategies to develop polymeric microneedles for controlled drug release
The remarkable appeal of microneedle controlled-release systems has captivated both the academic community and pharmaceutical industry due to their great potential for achieving spatiotemporally controlled release, coupled with the minimally invasive nature and ease of application. Over the years,…
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Detachable-Dissolvable-Microneedle as a potent subunit vaccine delivery device that requires no…
Although vaccine administration by microneedles has been demonstrated, delivery reliability issues have prevented their implementation. Through an ex vivo porcine skin experiment, we show visual evidence indicating that detachable dissolvable microneedles (DDMN) can deposit cargo into the dermis…
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Recent advances in micro- and nano-scale carrier systems for controlled delivery of vaccines
Vaccines provide substantial safety against infectious diseases, saving millions of lives each year. The recent COVID-19 pandemic highlighted the importance of vaccination in providing mass-scale immunization against outbreaks. However, the delivery of vaccines imposes a unique set of challenges due…
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Microneedle-based biosensing
Microneedles (MNs) are microscopic needles that are applied to the skin in a minimally invasive way to facilitate transdermal drug delivery and/or uptake of interstitial fluid from the skin, which contains a variety of metabolites that can serve as biomarkers. The collection of interstitial fluid…
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Microneedles for advanced ocular drug delivery
In the field of ocular drug delivery, topical delivery remains the most common treatment option for managing anterior segment diseases, while intraocular injections are the current gold standard treatment option for treating posterior segment diseases. Nonetheless, topical eye drops are associated…
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Microneedle array-based electrochemical sensor functionalized with SWCNTs for the highly sensitive…
Illicit drug consumption constitutes a great concern worldwide due to its increased spread and abuse, and the negative consequences exerted on society. For instance, 3,4-methylenedioxymethamphetamine (MDMA), a synthetic amphetamine-type substance, was abused by 20 million people worldwide in…
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Micro array patch assisted transdermal delivery of high dose, ibuprofen sodium using…
Current study reports the combined technique of microneedle array patches and thermoresponsive gels. Microneedles array patch mediated in situ skin depots were evaluated for sustain drug delivery using sodium alginate/Poly (vinylcaprolactam) thermoresponsive gels. Their phase transition property…
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Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System
Skin diseases are among the most prevalent non-fatal conditions worldwide. The transdermal drug delivery system (TDDS) has emerged as a promising approach for treating skin diseases, owing to its numerous advantages such as high bioavailability, low systemic toxicity, and improved patient…
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Drug delivery systems for thyroid disease treatment: A mini review on current therapies and…
Thyroid hormones play an important role in many metabolic processes in the human body. However, these processes can often be disrupted by an over or underactivity of the thyroid gland which, if undiagnosed or untreated, can result in serious illness. Currently, therapeutic management of an…
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Long-acting microneedle formulations
The minimally-invasive and painless nature of microneedle (MN) application has enabled the technology to obviate many issues with injectable drug delivery. MNs not only administer therapeutics directly into the dermal and ocular space, but they can also control the release profile of the active…
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