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Microneedle
Leveraging novel innovative thermoresponsive polymers in microneedles for targeted intradermal…
Abstract
Microneedles have garnered considerable attention over the years as a versatile pharmaceutical platform that could be leveraged to deliver drugs into and across the skin. In the current work, poly (N-isopropylacrylamide) (PNIPAm) is synthesized and characterized as a novel material for the…
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Intradermal delivery of the antiretroviral drugs cabotegravir and rilpivirine by dissolving…
The lymphatic system possesses the main viral replication sites in the body following viral infection. Unfortunately, current antiretroviral agents penetrate the lymph nodes insufficiently when administered orally and, therefore, cannot access the lymphatic system sufficiently to interrupt this…
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Design, optimization, and evaluation for a long-time-released transdermal microneedle delivery…
Transdermal drug delivery systems (TDDS) have drawbacks such as poor absorption, low blood concentration, and delayed effects. Dissolving microneedle has sharp tips and short length, which overcome patients’ pain and improve transdermal efficiency but has low mechanical strength and drug loading…
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Microneedle-Mediated Transdermal Delivery of Genetic Materials, Stem Cells, and Secretome: An Update…
Abstract
Medical practitioners commonly use oral and parenteral dosage forms to administer drugs to patients. However, these forms have certain drawbacks, particularly concerning patients’ comfort and compliance. Transdermal drug delivery presents a promising solution to address these issues.…
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Nanocrystals and nanosuspensions: an exploration from classic formulations to advanced drug delivery…
Nanocrystals and nanosuspensions have become realistic approaches to overcome the formulation challenges of poorly water-soluble drugs. They also represent a less-known but versatile platform for multiple therapeutic applications. They can be integrated into a broad spectrum of drug delivery systems…
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Fabrication of dissolving microneedles for transdermal delivery of protein and peptide drugs:…
Proteins and peptides are rapidly developing pharmaceutical products and are expected to continue growing in the future. However, due to their nature, their delivery is often limited to injection, with drawbacks such as pain and needle waste. To overcome these limitations, microneedle technology is…
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Strategies to develop polymeric microneedles for controlled drug release
The remarkable appeal of microneedle controlled-release systems has captivated both the academic community and pharmaceutical industry due to their great potential for achieving spatiotemporally controlled release, coupled with the minimally invasive nature and ease of application. Over the years,…
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Detachable-Dissolvable-Microneedle as a potent subunit vaccine delivery device that requires no…
Although vaccine administration by microneedles has been demonstrated, delivery reliability issues have prevented their implementation. Through an ex vivo porcine skin experiment, we show visual evidence indicating that detachable dissolvable microneedles (DDMN) can deposit cargo into the dermis…
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Recent advances in micro- and nano-scale carrier systems for controlled delivery of vaccines
Vaccines provide substantial safety against infectious diseases, saving millions of lives each year. The recent COVID-19 pandemic highlighted the importance of vaccination in providing mass-scale immunization against outbreaks. However, the delivery of vaccines imposes a unique set of challenges due…
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Microneedle-based biosensing
Microneedles (MNs) are microscopic needles that are applied to the skin in a minimally invasive way to facilitate transdermal drug delivery and/or uptake of interstitial fluid from the skin, which contains a variety of metabolites that can serve as biomarkers. The collection of interstitial fluid…
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