STYL’One Evo - Advanced Compaction Simulator

Research and Development in Focus

With over 125 years of combined experience with small-scale, fully instrumented machines, KORSCH and MEDELPHARM offer the most advanced line of tablet compression technology in the world.

The combined R&D product line meets and exceeds every requirement, from early-stage powder characterization and formulation development, to scale-up and production support.

It covers the full spectrum of tableting technology from single-layer to five-layer, as well as Tab-in-Tab. MEDELPHARM compaction simulators are the perfect complement to the KORSCH product line.

The Most Versatile Compaction Simulator

The STYL’One Evo is the most advanced compaction simulator and has the capability to produce virtually any tablet format. The machine features 50 kN pre/main compression force capability as a standard, up to 120 kN as an option.

The machine permits the use of standard EU/TSM B, D, and EU-441 tooling. Special tooling for larger formats, or multi-tip tools for mini-tablets can also be utilized. The STYL’One Evo is an easy to use, easy to clean R&D press.

Work with minimal material quantities
Work with USP<1062> compression profiles
Work with compression kinetics similar to production

Understand
and Formulate
your Product

Single-layer
Multi-layer
Tab-in-Tab

Develop any
Type of Tablet

Simulate any high-speed production press
Define optimal process parameters
Produce small technical and clinical batches

Scale-up to
Production

Simulate any roller compactor
Determine suitable production parameters
Fast feasibility assessment with minimal amount of powder

Study Dry
Granulation

The STYL’One Evo is very flexible and can be equipped with a wide range of accessories and software modules to accommodate virtually any product development requirement. The powerful software is very intuitive and the machine permits tablet format changes in just minutes.

Compression studies can be planned and executed in a simple and efficient manner, with the capability to create an experiment using standard profiles (saw tooth or square wave), or replicate a high-speed production press. The STYL’One Evo is offered in DryCon® and WipCon® containment executions.

Characterization of API and Formulations

The STYL’One Evo comes fully instrumented to provide precise understanding of powder tableting behavior and to evaluate the effect of Process Parameters (PP) on tablet Quality Attributes (QA). Additional accessories enable you to measure radial die wall pressure and take off force.

With minimal quantities
Comparison of different sources of material
Formulation development and optimization

Flexible Configuration

The STYL’One Evo permits the production of single-layer and multi-layer up to five-layer tablets with three different products. A core feeding system permits automated positioning of cores onto the powder bed for Tab-in-Tab applications.

Intuitive multi-layer and Tab-in-Tab software modules
Quick conversion between the different tablet formats
Retrofittable at any time

Simulation of any Rotary Tablet Press

The STYL’One Evo can reproduce the high compression speed of large production rotary presses. A micro dispensing unit allows tablet development using external lubrication. The machine can be connected to tablet testers for automatic data transfer and computation.

Comprehensive library of rotary press compression profiles
External lubrication feasibility assessment Good and bad tablet sorting chute
GMP production module with automatic weight regulation

Simulation of any Roller Compactor

Lab-size roller compactors have identical roller diameters of those installed on production-scale machines, requiring a large amount of powder, whereas a unique tool like the STYL’One Evo can simulate roller compactors with a very limited amount of product.

Roller compaction software module
Dry granulation feasibility assessment
Specific library of roller compactor profiles
Quickly target a specific solid fraction

STYL’One Evo Advanced Compaction Simulator

Tableting has never been so easy to investigate, from pure API characterization and formulation development to scaleup at production speeds.The versatility of the STYL’One Evo covers all tablet formats from single to five-layer, including core placement for Tab-in-Tab.

The machine is equipped with a unique drive technology in a compact footprint which is ideal for the laboratory environment. The simulator can operate in a displacement mode to replicate any rotary press, or in a compression force mode where the system will produce tablets at preset force targets.

The powerful and intuitive data acquisition and analysis software is integrated in the STYL’One Evo which supports full understanding of powder tableting behavior.

Benefits at a Glance

Easy handling and cleaning
Innovative drive technology
Standard EU/TSM B&D tooling
Full instrumentation (force & displacement)
Ideal for minimal quantities
Simulation of any rotary tablet press
Multi-layer & Tab-in-Tab modules
Roller compactor simulation module
Powerful data acquisition and analysis software
Fast Design of Experiment (DoE) execution
DryCon® and WipCon® executions

See the full technical brochure on STYL’One Evo here

(click the picture to download the brochure)

STYL’One Evo - Advanced Compaction Simulator — STYL’One Evo – Advanced Compaction Simulator

Source: MEDELPHARM technical brochure STYL’One Evo

Maybe you can take part in the MEDELPHARM university contest – Have a look!

MEDELPHARM STYL'One University Contest — MEDELPHARM STYL’One University Contest

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