ANOVEL FILM COATING FORMULATION TO MINIMIZE COLOUR FADING
Introduction
It is common practice within the pharmaceutical industry to enhance the aesthetic appearance of dosage forms by using suitably colored film coatings (1). Colored coatings increase patient acceptability and compliance, improve safety via easy identification and differentiation and may reduce degradation via increased opacity to light. Indigo Carmine (FD & C Blue #2) or Indigotine is approved in US and European Markets to be used as a colorant in oral and topical preparations. It is known to have good heat stability but poor stability to light and oxidizing agents. Thus formulations containing Indigo Carmine tend to fade with time.
Co-povidone is a one of the polymers which has been used to reduce colour fading issues in film coating systems.
