Developing sustained release tablets with Compritol® 888 ATO
Compritol® 888 ATO is a fine white powder, insoluble in water and organic solvents. It has no odor and no taste. It is used as lubricant, coating agent for the protection of sensitive drugs, in taste masking and as a matrix former in sustained release.
Compritol® 888 ATO is an ester of mono-, di- and triglycerides, the die-ester fraction is predominant (40 – 60%). It is composed of glycerol and fatty acids of behenic acid (C22) from vegetable origin (Figure 3-1). Gattefossé production process ensures Compritol® 888 ATO batches have high reproducibility and constant composition.
Compritol® 888 ATO particles have a spherical shape (Figure 3-2), a mean particle size of 50 μm and a narrow size distribution.
Main features of Compritol® 888 ATO in SR matrices
Compritol® 888 ATO combines several advantages when used as a sustained release matrix agent.
- Drug release from a Compritol® 888 ATO matrix is diffusion controlled and not driven by swelling and erosion. This facilitates simple product design, including straightforward modulation of drug release and high reproducibility.
- A Compritol® 888 ATO matrix is not sensitive to physiological variations such as pH, digestion or alcohol. It makes biopharmaceutically robust tablets.
- Versatile use of Compritol® 888 ATO in many processing techniques favors product optimization and provides scope for innovation in solid oral dosage form development.