Dry Powder Inhalers (DPI)

Abstract Pulmonary drug delivery presents a promising approach for managing respiratory diseases, enabling localized drug deposition and minimizing systemic side effects. Building upon previous research, this study investigates the cytotoxicity, permeability, and stability of a novel carrier-free…
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Abstract In addition to the known therapeutic indications for cannabidiol, its administration by inhalation appears to be of great interest. Indeed, there is evidence of cannabidiol's efficacy in several physiological pathways, suggesting its potential for a wide range of applications for both…
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Abstract This study investigated a capsule’s powder evacuation behavior when rotating about its minor axis in a cross flow and considering the effects of rotation speed and flow rate on powder emission. The experimental platform, an optically accessible capsule chamber, was designed to uncover the…
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This poster was presented by MEGGLE with the Kiel University for Pharmaceutics and Biopharmaceutics: Introduction Interactive blends require adhesion between carrier and API to be modulated. Several studies concluded causal relationship between decreased surface energy (SE) of either…
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Abstract Background: Spray drying, whilst a popularly employed technique for powder formulations, has limited applications for large-scale proliposome manufacture. Objectives: Thus, the aim of this study was to investigate spray drying parameters, such as inlet temperature (80, 120, 160, and 200…
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Abstract Invasive pulmonary aspergillosis poses a significant threat to immunocompromised patients, characterized by high mortality rates. Posaconazole (PSZ), a second-generation triazole antifungal, exhibits broad-spectrum activity but suffers from limited pulmonary concentrations and notable…
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This study aimed to establish a feasible dissolution method for inhalation aerosols. A method of collecting fine particles was investigated to capture aerosol particles less than 4 μm in diameter for dissolution tests. This dose collection method enabled the aerosol particles to be uniformly…
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Roquette, a global leader in plant-based ingredients and a leading provider of pharmaceutical and nutraceutical excipients, welcomed CPHI Milan attendees to explore the synergistic potential of its expanded excipients portfolio, a year after the acquisition of leading capsule manufacturer,…
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Introduction Many respiratory pathogens enter the body through the respiratory tract, the lungs and the mucosal immune system are promising targets for therapeutic interventions. Liquid vaccines face the risk of chemical degradation and physical instability -> Solid formulations can…
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Abstract The dynamics of cohesive particles and their tendency to adhere to surfaces present significant challenges in various industrial processes. A profound understanding of adhesive and cohesive forces is crucial for the optimized design of continuous manufacturing systems, aiming to…
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