Dry Powder Inhalers (DPI)

Abstract Objective To evaluate the storage and in-use stability of a novel synthetic lung surfactant (SLS) excipient enhanced growth (EEG) powder formulation. Significance Aerosol delivery of surfactant formulations could address limitations of current instilled surfactant replacement therapy…
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Abstract Fine powders are required in many industrial applications, but their poor flow properties make handling and processing challenging. In Dry Powder Inhalation (DPI), for instance, inhaled particles must have an aerodynamic diameter between 1 and 5 μm to ensure therapeutic efficiency.…
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Abstract Inhalation delivery of biologics as dry powders offers a promising alternative to liquid formulations, eliminating the need for cold storage. However, controlling particle properties for efficient lung delivery is challenging. While spray drying (SD) has been successfully used, it often…
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Abstract Pulmonary drug delivery presents a promising approach for managing respiratory diseases, enabling localized drug deposition and minimizing systemic side effects. Building upon previous research, this study investigates the cytotoxicity, permeability, and stability of a novel carrier-free…
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Abstract In addition to the known therapeutic indications for cannabidiol, its administration by inhalation appears to be of great interest. Indeed, there is evidence of cannabidiol's efficacy in several physiological pathways, suggesting its potential for a wide range of applications for both…
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Abstract This study investigated a capsule’s powder evacuation behavior when rotating about its minor axis in a cross flow and considering the effects of rotation speed and flow rate on powder emission. The experimental platform, an optically accessible capsule chamber, was designed to uncover the…
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This poster was presented by MEGGLE with the Kiel University for Pharmaceutics and Biopharmaceutics: Introduction Interactive blends require adhesion between carrier and API to be modulated. Several studies concluded causal relationship between decreased surface energy (SE) of either…
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Abstract Background: Spray drying, whilst a popularly employed technique for powder formulations, has limited applications for large-scale proliposome manufacture. Objectives: Thus, the aim of this study was to investigate spray drying parameters, such as inlet temperature (80, 120, 160, and 200…
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Abstract Invasive pulmonary aspergillosis poses a significant threat to immunocompromised patients, characterized by high mortality rates. Posaconazole (PSZ), a second-generation triazole antifungal, exhibits broad-spectrum activity but suffers from limited pulmonary concentrations and notable…
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This study aimed to establish a feasible dissolution method for inhalation aerosols. A method of collecting fine particles was investigated to capture aerosol particles less than 4 μm in diameter for dissolution tests. This dose collection method enabled the aerosol particles to be uniformly…
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