From lead to investigational new drug
The new e-Guide covers successful preclinical studies with Gattefossé excipients. Gattefossé developed a guideline to help formulate molecules with poor solubility and oral bioavailability into more drug-like compounds. The approaches described will provide effective strategies to obtain the target dose, sufficient to allow the characterization and optimization of the pharmacokinetic, efficacy and safety profile. The aim is to help formulators work with Gattefossés excipients to get the best results possibly reducing the risk of failure later on during development.
See the video here:
The Guideline covers
- Enabling strategies for efficacy, PK and safety evaluation
- Safety and tolerability information
- Handling and dosing recommendations
- Excipient summary tables