Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application
In this study, the abilities of hydroxypropyl methylcellulose (HPMC) and methylcellulose (MC) as nonionic surfactants to improve the dissolution rate of carvedilol solid dispersions (CAR SDs) with Kollicoat IR as a carrier were clearly demonstrated.
CAR SDs were prepared using the solvent evaporation method, and their physicochemical properties were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The results suggested that CAR in SDs existed in an amorphous form. In vitro dissolution experiments and molecular docking (MD) simulations were conducted to confirm the storage stability of CAR SDs. In order to study the mechanism of solubilization ability, molar solubilization ratio (MSR) and micelle-water partition coefficient (Kmic) were calculated.
The results showed that the MSR and logKmic values of MC/Kollicoat IR 1:3 were around 30-fold higher than the single surfactants. Above all, HPMC and MC have great potentials to improve the dissolution characteristics of CAR-Kollicoat IR SDs. More on solid dispersions