HPMC – Hydroxypropylmethylcellulose

Abstract Metformin is a relatively old drug mainly used to treat type 2 and gestational diabetes, which needs to be administered two or three times a day in high doses. It has a high aqueous solubility and is poorly absorbed following oral intake. Aiming to achieve a gastroretentive formulation for…
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Abstract Hydroxypropyl methylcellulose (Hypromellose, HPMC) is a well-known excipient used in the pharmaceutical and nutraceutical fields due to its versatile physicochemical properties. HPMC (derived from cellulose and obtained through etherification) varies in polymerization degree and viscosity,…
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Abstract Purpose Azelaic acid (AZE) is a widely used agent in acne treatment, but its poor water solubility limits its therapeutic potential. In this study, the effectiveness of azelaic acid (AZE)—a compound with limited therapeutic efficacy due to its poor water solubility—was investigated in…
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Abstract Fast screening of amorphous solid dispersions (ASDs) is a need in the pharmaceutical industry. To support this, several emerging technologies have been developed ranging from in-silico prediction to miniaturized high-throughput experimentation. However, a notable challenge lies in the…
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Abstract Poor aqueous solubility and slow dissolution rate of active pharmaceutical ingredients (APIs) are often encountered challenges during oral drug development, leading to variable and insufficient bioavailability. To overcome these challenges, a so-called “enabling” formulation strategy is…
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Abstract Predicting the tabletability, i.e., the relationship between tensile strength and compaction pressure, of powder mixtures based on that of pure materials would streamline tablet formulation development, saving both time and materials. This would be a significant step toward achieving…
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Abstract Poor aqueous solubility and slow dissolution rate of active pharmaceutical ingredients (APIs) are often encountered challenges during oral drug development, leading to variable and insufficient bioavailability. To overcome these challenges, a so-called “enabling” formulation strategy is…
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Abstract Objective To evaluate the storage and in-use stability of a novel synthetic lung surfactant (SLS) excipient enhanced growth (EEG) powder formulation. Significance Aerosol delivery of surfactant formulations could address limitations of current instilled surfactant replacement therapy…
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Abstract Aim: The study aimed to develop a once-daily sustained-release gastroretentive combination formulation of bepotastine besilate and montelukast sodium using multilayer tablet technology and gastro-retentive systems for the treatment of allergic rhinitis and asthma. Background:…
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Abstract Novel topical nanosponges were implemented to improve the skin availability of simvastatin (SV) for treating full-thickness wounds while controlling the scarring process. SV exhibits great potential in treating various skin diseases owing to its antibacterial, antioxidant,…
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