Trehalose

Abstract Background/Objectives: The stability and biological safety of newly developed formulations must be established to support their therapeutic efficacy and...

Abstract Spray freeze-drying (SFD) is a cutting-edge technique for producing dry powders, ideal for pulmonary drug delivery, owing to its...

Abstract BACKGROUND: The choice of excipient is important in enhancing stability of liquid formulations containing lipid nanoparticles (LNPs) used in...

Abstract To facilitate the development of protein depots for sustained delivery, this study optimized spray-dried formulations of a model antibody...

Abstract Therapeutic proteins have emerged as a cornerstone of modern medicine due to their high specificity and strong biological effects....

Biopharmaceutical excipients are the inactive substances added to biologic drug products to protect large, structurally fragile biomolecules, such as monoclonal...

Abstract Preservatives are critical for preventing microbial contamination in multi-dose biologics, yet their compatibility with proteins poses a major challenge....

Abstract Carbohydrates play a pivotal role in reshaping micellar organization. This study explores how glucose (a monosaccharide), trehalose (a disaccharide),...

Abstract Hypothesis During spray freeze drying (SFD), vitrification, recrystallization, and polymorphic transitions govern particle morphology and mechanical integrity. We hypothesize...

Abstract Background/Objectives: Reproducible evaluation of aerosol dispersibility remains a key challenge in the development of dry powder inhalers (DPIs), where small...