Trehalose

The large-scale global application of messenger ribonucleic acid–lipid nanoparticles (mRNA-LNPs) is severely restricted by their mandatory ultra-low-temperature storage requirement, which...

Abstract The aim of this study was to assess to what extent a simulated trehalose monolayer can predict the minimum...

Abstract Spray-freeze drying (SFD) is a promising drying technique for stabilizing RNA lipid nanoparticles (RNA-LNPs) by converting them into solid-state...

Abstract Background/Objectives: The stability and biological safety of newly developed formulations must be established to support their therapeutic efficacy and...

Abstract Spray freeze-drying (SFD) is a cutting-edge technique for producing dry powders, ideal for pulmonary drug delivery, owing to its...

Abstract BACKGROUND: The choice of excipient is important in enhancing stability of liquid formulations containing lipid nanoparticles (LNPs) used in...

Abstract To facilitate the development of protein depots for sustained delivery, this study optimized spray-dried formulations of a model antibody...

Abstract Therapeutic proteins have emerged as a cornerstone of modern medicine due to their high specificity and strong biological effects....

Biopharmaceutical excipients are the inactive substances added to biologic drug products to protect large, structurally fragile biomolecules, such as monoclonal...

Abstract Preservatives are critical for preventing microbial contamination in multi-dose biologics, yet their compatibility with proteins poses a major challenge....