Trehalose

Abstract Background Process intensification is a major hurdle in pharmaceutical process scale-up. Solvent removal strategies have limited the effectiveness of the overall stability of pharmaceutical formulations. The main aim of present review article is to focus on the use of the freeze-drying…
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Although vaccine administration by microneedles has been demonstrated, delivery reliability issues have prevented their implementation. Through an ex vivo porcine skin experiment, we show visual evidence indicating that detachable dissolvable microneedles (DDMN) can deposit cargo into the dermis…
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Insulin is classified as a cold chain product due to being a peptide hormone with stability issues in the liquid preparation. Therefore, insulin was developed into the dry powder form to improve the stability and application for nose-to-brain delivery in Alzheimer’s disease treatment. Insulin was…
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One of the strategies proposed for the neutralization of SARS-CoV-2 has been to synthetize small proteins able to act as a decoy towards the virus spike protein, preventing it from entering the host cells. In this work, the incorporation of one of these proteins, LCB1, within a spray-dried…
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Excipients are used to improve the stability of protein-based therapeutics by protecting the protein against a range of stress conditions such as temperature changes, pH changes, or agitation. Similar stresses are applied to proteins during downstream purification. Shifts in pH during Protein A…
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Bio-based surfactants exerting both functional and nutritional properties are needed in the food industry. This study reports the one-pot synthesis, using a Novozym 435-catalyzed trans-esterification protocol, of a new family of such compounds, namely a homologous series of 6-O-acylated trehalose …
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Press release Nagase/Hayashibara will be attending the AAPS 2023 PharmSci 360 in Orlando, FL, USA. AAPS 2023 PharmSci 360 in Orlando, FL, Orange County Convention Center Nagase/Hayashibara Booth #3046 Poster Session M0930-04-23, Oct 23, 9:30-10:30 Title: Beneficial Effects of Trehalose…
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The drying of biomolecules into powdered formulations has become the main form of long-term product stabilisation, allowing for the delivery of safe and efficient medicines. Stability of proteins and peptides during the drying process is paramount for product quality. Drying macromolecules with an…
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Lipid liquid crystalline nanoparticles (LCNPs) are unique nanocarriers that efficiently deliver antimicrobials through biological barriers. Yet, their wide application as an antimicrobial delivery system is hindered by their poor stability in aqueous dispersions. The production of dried LCNP powder…
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In recent years, probiotics have expanded from their traditional classification as “health promoting food” to the development of live biotherapeutic products (LBP). Traditional probiotics are marketed as food/dietary supplements while LBPs are drug products intended for treatment or prevention of…
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