Trehalose

Abstract Surface adsorption of proteins in bulk drug product formulations and loss of protein structural integrity during manufacturing processes can...

Abstract The transdermal delivery of large molecules such as proteins and vaccines faces enormous challenges and at the same time...

Abstract Lyophilization enhances mRNA vaccine stability, but conventional approaches using external trehalose for lipid nanoparticle (LNP) colloidal stability neglect mRNA...

Abstract Posaconazole (PCZ) is a broad spectrum anti-fungal drug approved by FDA and currently used off-label for the treatment of...

The transition of immunotherapy administration from intravenous infusion to subcutaneous (SC) administration of monoclonal antibody formulations for oncology patients has...

Abstract Similar to other routes of administration, pulmonary formulations typically contain excipients. The panel of substances that can be used...

Abstract This research study aimed to develop and evaluate a novel freeze-dried nanocrystals formulation of sotorasib (AMG-510) using Quality by...

Abstract Vaccines rely on a global cold chain to maintain vaccine potency throughout the product life cycle. Existing vaccine thermostabilization...

Abstract The provision of effective probiotic formulations requires gentle processing to maintain the viability of the probiotic microorganisms, which is...

Abstract For monoclonal antibody drug products as for other biologics, while the innovator drug products first becomes commercially available, they...