The effects of the treatment conditions on the dissolution profile of ethylcellulose coated pellets

6. March 2019

Due to the additional particle coalescence in the coating, changes in the dissolution profile occur over time in the formulations...

Polymer Distribution and Mechanism Conversion in Multiple Media of Phase-Separated Controlled-Release Film-Coating

22. February 2019

Phase-separated films of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC) can be utilized to tailor drug release from...

Age-dependent capabilities of patients and feasible drug product concept

Drug Product Development for Older Adults – Multiparticulate Formulations

21. February 2019

The multiparticulate drug product concept covering micropellets, pellets,and mini-tablets is presented as a highly feasible approach to present convenient and...

Non-aqueous formulations for ram and screen extrusion-spheronisation

19. February 2019

The use of non-aqueous cellulose-based formulations for extrusion-spheronisation (E-S) is investigated. A 10 wt% hydroxypropyl cellulose/isopropyl alcohol solution (HPC/IPA) was...

A Study on the Applicability of Multiple Process Analysers in the Production of Coated Pellets

14. February 2019

Process analytical technology (PAT) has become an important factor in design, analysis and control of complex technological processes. In the...

Evaluation of in-line particle measurement with an SFT-probe as monitoring tool for process automation using a new time-based buffer approach to

14. December 2018

The Process Analytical Technology (PAT) initiative published by the Food and Drug administration (FDA) describes PAT systems as important tools...

Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulations

28. November 2018

The aim of this work was to evaluate gellan gum as binder in pellet formulations, with theophylline as the model...

Chart about hot-melt extruded lipidic pellets

Hot-melt extruded lipidic pellets for pediatric applications: An investigation of the effects and stability on drug dissolution

1. November 2018

The current study investigates the development of extemporaneous preparation of hot melt extruded diclofenac sodium (Df-Na) pellets processed with glyceryl...

Flowchart of hydrocortisone and child-appropriate administration fluids

Biorelevant in vitro assessment of dissolution and compatibility properties of a novel paediatric hydrocortisone drug product following exposure of the drug product to child-appropriate administration fluids

1. November 2018

Alkindi® is a novel oral multi-particulate taste-masked formulation of hydrocortisone for use in children with the rare disease adrenal insufficiency....

Development of high drug loaded pellets by Design of Experiment and population balance model calculation

31. October 2018

Medicines of drug coated inert pellets filled into hard capsules or compressed into tablets are already on the market, until...

Pellet