Petrochemicals

Abstract Drug delivery products based on poly(lactic-co-glycolic acid) (PLGA) often have multiphasic drug release profiles with slow “lag phase(s)” and rapid “burst phase(s),” which can limit therapeutic efficacy. The purpose of this study was to develop voriconazole (VCZ)/PLGA intravitreal…
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Abstract Liquisolid systems prepared in a fluidised bed processor were investigated to evaluate the suitability of four different porous excipients (Fujicalin®, Neusilin® US2, Syloid® XDP 3050 and Syloid® XDP 3150) as carriers in high liquid content formulations. PEG 400 was used as liquid phase…
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Abstract Having an in vitro dissolution method providing meaningful and translatable data is critical for early-stage research and development. For long-acting injectables, such as in situ forming depots (ISFD), the extended duration of the release test and the different release mechanisms involved…
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Abstract Turner syndrome, a rare chromosomal disorder affecting 1 in 2500 females, is characterized by the partial or complete absence of the second X chromosome. The primary treatment involves oestradiol (E2) hormone replacement therapy, essential for inducing puberty and maintaining secondary sex…
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Abstract The underlying mechanisms governing amorphous solid dispersions (ASDs) stability are complex and influenced by multiple factors, making it a difficult problem to address comprehensively. The current study investigates how various factors affect the long-term physical stability of ASDs,…
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Abstract In commercial applications, sofosbuvir (SOF) for hepatitis C is only available in tablet dosage form, resulting in minimal SOF accumulation in the liver (26.94%) due to its low intestinal permeability and high molecular weight (529.5 Da). Therefore, in this study, luminar capsule…
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Abstract Purpose This study aims to improve the therapeutic effect of leflunomide (LEF), an immune-altering drug, and resveratrol (RSV), a polyphenolic compound distributed locally in the body. LEF and RSV were encapsulated in nanostructured lipid carriers (NLCs). Method NLCs were prepared by…
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Abstract Aim: In addition to numerous benefits provided by nanosuspensions (NSs) (e.g., enhanced saturation solubility, increased area for interaction with fluids), they suffer from major stability, handling and compliance issues. To overcome these challenges, we evaluated the feasibility of hot…
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Abstract Fast screening of amorphous solid dispersions (ASDs) is a need in the pharmaceutical industry. To support this, several emerging technologies have been developed ranging from in-silico prediction to miniaturized high-throughput experimentation. However, a notable challenge lies in the…
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Abstract Drug nanocrystals (NCs) have entirely changed the panorama of drug delivery, enabling enhanced drug absorption and long-acting drug release. The vast majority of marketed NCs-based products are obtained via media milling using of-the-shelf industrial machinery. However, early-stage…
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