Experimental investigation of compression and wetting behavior of liquisolid systems with different porous carriers prepared via fluid bed processing
Abstract
Liquisolid systems prepared in a fluidised bed processor were investigated to evaluate the suitability of four different porous excipients (Fujicalin®, Neusilin® US2, Syloid® XDP 3050 and Syloid® XDP 3150) as carriers in high liquid content formulations. PEG 400 was used as liquid phase and colloidal silicon dioxide as coating material. The prepared formulations were tested for their flowability, compaction properties and wetting behaviour. The results show that all tested liquisolid mixtures exhibited acceptable flowability. Compaction was carried out using a compaction simulator to investigate all stages of the tableting process.
Formulations with Fujicalin® and Neusilin® US2 as carriers showed better tabletability, compressibility and compactibility as well as lower values for detachment stress, elastic recovery and work of compression than the formulations with Syloid® XDP carriers. On the other hand, the liquisolid systems with Syloid® XDP carriers exhibited higher porosity, which, together with their mechanical properties, resulted in a shorter wetting time and overall good wettability. The shortest wetting time was observed for liquisolid systems with the Syloid® XDP 3150 carrier.
The amount of coating material used did not appear to have a pronounced effect on either the mechanical properties or the wettability of the formulations tested. Of the four carriers considered, Neusilin® US2 stood out as the carrier capable of absorbing the largest amount of liquid phase (about 110-125% of its mass) while ensuring good flowability of the liquisolid mixtures, satisfactory mechanical properties and acceptable wettability of the liquisolid compacts.
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Materials
Two types of amorphous mesoporous silicon dioxide (Syloid® XDP 3050 and Syloid® XDP 3150, Grace GmbH, Germany), amorphous magnesium aluminometasilicate (Neusilin® US2, Fuji Chemical Industry Co, Ltd., Japan) and dibasic calcium phosphate anhydrous (Fujicalin®, Fuji Chemical Industry Co, Ltd., Japan) were used as carriers in the liquisolid systems. Colloidal silicon dioxide (Aerosil 200, Evonik Industries AG, Germany) was the coating material of choice and polyethylene glycol 400.
Teodora Glišić, Ilija German Ilić, Stefan Pavlović, Ivana Aleksić, Experimental investigation of compression and wetting behavior of liquisolid systems with different porous carriers prepared via fluid bed processing, Journal of Drug Delivery Science and Technology, 2025, 107204, ISSN 1773-2247, https://doi.org/10.1016/j.jddst.2025.107204.
Read also our introduction article on Mesoporous Silica here:
