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Phospholipids
Evaluation of Oromucosal Natural Gum-Based Emulgels as Novel Strategy for Photodynamic Therapy of…
Photodynamic therapy (PDT) recently has been shown as a promising option in the treatment of premalignant lesions of the soft oral tissues. Effective delivery of photosensitizer is challenging due to poor drug adherence to the oromucosal epithelium. In the present work, emulgels composed of natural…
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Harnessing the multifunctionality of lipid-based drug delivery systems for the local treatment of…
Osteoarthritis (OA) is a widespread joint condition affecting millions globally, presenting a growing socioeconomic burden thus making the development of more effective therapeutic strategies crucial. This review emphasizes recent advancements in lipid-based drug delivery systems (DDSs) for…
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Excipient Impact on Fenofibrate Equilibrium Solubility in Fasted and Fed Simulated Intestinal Fluids…
Solubility is a critical parameter controlling drug absorption after oral administration. For poorly soluble drugs, solubility is influenced by the complex composition of intestinal media and the influence of dosage form excipients, which can cause bioavailability and bioequivalence issues. This…
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Processed excipients for targeted drug delivery in cancer management: Enhancing efficacy and…
Processed excipients (PEs) function in creating various dosage forms and need no introduction. For instance, recent studies have shown that PEs oleic acid, which is used with the breast cancer medicine Herceptin, functions both as a liquid delivery system for drugs and has the ability to suppress…
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The Anti-Oxidant Curcumin Solubilized as Oil-in-Water Nanoemulsions or Chitosan Nanocapsules…
Abstract
The bacterium Helicobacter pylori (H. pylori) represents a major risk factor associated with the development of gastric cancer. The anti-oxidant curcumin has been ascribed many benefits to human health, including bactericidal effects. However, these effects are poorly reproducible because…
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QbD-driven development of phospholipid-embedded lipidic nanocarriers of raloxifene: extensive in…
Raloxifene (RLX) is popularly indicated in treatment of osteoporosis and prevention of breast cancer. Owing to its poor aqueous solubility, high pre-systemic metabolism, intestinal glucuronidation, and P-glycoprotein (P-gp) efflux, however, it demonstrates low (< 2%) and inconsistent oral…
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Carrageenan tethered ion sensitive smart nanogel containing oleophytocubosomes for improved ocular…
Ophthalmic delivery of luteolin (LU) was studied after formulating a carrageenan-based novel ion-sensitive in situ gel (ISG) incorporating oleophytocubosomes for prolonged ocular residence time and improved ocular bioavailability of the poorly absorbed herbal drug luteolin. The prepared…
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Polyenylphosphatidylcholines as bioactive excipient in tablets for the treatment of liver fibrosis
Liver fibrosis is a condition characterized by the accumulation of extracellular matrix (ECM) arising from the myofibroblastic transdifferentiation of hepatic stellate cells (HSCs) occurring as the natural response to liver damage. To date, no pharmacological treatments have been specifically…
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Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies
Abstract
The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist, they come with challenges such as a heavy pill regimen, prolonged treatment duration, and a strict schedule,…
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Preparation and formula optimization of cephalexin loaded transferosomal gel by QbD to enhance the…
Most antibiotics used in topical formulations are not absorbed by deeper skin layers and subdermal tissues. Hence the skin infections are treated with large doses of oral or parenteral antibiotics which lead to unpleasant side effects with drug resistance. This could be the necessity for the…
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